Research Progress on Biodegradable Zn-Based Alloy Materials

Wang Heng; Yang Kang; Ma Yiming; Xu Lin

doi:doi:10.11648/j.ajls.20231104.12

| Peer-Reviewed

Research Progress on Biodegradable Zn-Based Alloy Materials

Wang Heng, Yang Kang, Ma Yiming, Xu Lin

Published in American Journal of Life Sciences (Volume 11, Issue 4)

Received: 10 July 2023 Accepted: 14 August 2023 Published: 15 August 2023

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

As biodegradable materials for biomedical purposes, people have done a lot of research on Mg alloy and Fe alloy. However, both types of materials have obvious shortcomings. Mg alloy degrades too rapid and the inhomogeneity degradation rate in the human environment, resulting in its mechanical properties rapidly declining and it cannot provide adequate support or fixing capacity. Fe alloy has a very slow degradation rate due to the good protective effect of its degradation products, resulting in similar problems to non-degradable material. In this situation, Zn alloys are often mentioned in recent years, because Zn is an essential trace element for the human body, and the standard potential of Zn is between Mg and Fe, so its degradation rate is excellent. At the same time, Zn-based alloy has become a new biodegradable biomedical material after Mg alloy and Fe alloy, and has been widely used in cardiovascular stents, bone implants and internal fixation devices, and gastrointestinal staplers. At present, there is no systematic research result on biodegradable biomedical Zn-based Alloy Materials, the research interests include composition design, processing and preparation, degradation principle, biocompatibility, mechanical properties in all aspects. This article reviewed the properties of Zn-based Alloy Materials compared with other typical alloys and pointed out the future development direction.

Published in	American Journal of Life Sciences (Volume 11, Issue 4)
DOI	10.11648/j.ajls.20231104.12
Page(s)	56-63
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Zn-Based Alloy, Trace Elements, Biocompatibility, Degradation Rate, Mechanical Property

References

[1]	Yin Zhengqing, Bai Jingyu, Lin Xiaofeng. Competitiveness analysis and enlightenment of biomedical industry in USA [J]. China Biotechnology, 2020, 40 (9): 87-94.
[2]	Fan Guanglong. Clinical application of degradable biomedical materials [J]. Chemical Engineering Management, 2020, 15: 154-155.
[3]	Zhang Wenyu. Research status and application progress of biomedical metal materials [J]. Metal World, 2020, 1: 21-27.
[4]	Li Juntao, Chen Zhouyu. Research status and prospect of biodegradable biomedical materials [J]. Advanced Materials Industry, 2016, 1: 32-35.
[5]	Mei Jiong. History and prospect of internal fixation operation of femoral neck fracture [J]. Chinese Journal of Bone and Joint, 015, 4 (2): 82-85.
[6]	Liang Huigang, Huang Ke. Development status and trend of biomedical polymer materials [J]. Advanced Materials Industry, 2016, 2: 12-15.
[7]	Xu Wenlil, Wu Jingyao, Tan Lili, et al. Research progress on iron-based biodegradable coronary stents [J]. Materials Reports, 2012, 26 (1): 75-78.
[8]	Wang Liqing, Ren Yuping, Qin Gaowu. Research Progress of Zn-Based Alloys as Biodegradable Materials [J]. Chinese Journal of Rare Metals, 2017, 41 (5): 571-578.
[9]	S. X. Zhang, X. N. Zhang, C. Zhao, et al. Research on an Mg–Zn alloy as a degradable biomaterial [J]. Acta Biomaterialia, 2010, 6 (2): 626-640.
[10]	S. F. Zhu, N. Huang, L. Xu, et al. Biocompatibility of pure iron: In vitro assessment of degradation kinetics and cytotoxicity on endothelial cells [J]. Materials Science and Engineering: C, 2009, 29 (5): 1589-1592.
[11]	Wang Luning, Meng Yao, Liu Lijun, et al. Research progress on biodegradable zinc-based [J]. Acta Metallurgica Sinica, 2017, 53 (10): 1317-1322.
[12]	Y. F. Zheng, X. N. Gu, F. Witte. Biodegradable metals [J]. Materials Science and Engineering: R: Reports, 2014, 77: 1-34.
[13]	Gong Daoliang. Patent analysis of biomedical degradable Zn-Mg alloys [J]. China Science and Technology Information, 2021, 11: 15-16.
[14]	F. Witte, N. Hort, C. Vogt, et al. Degradable biomaterials based on magnesium corrosion [J]. Current Opinion in Solid State and Materials Science, 2008, 12 (5-6): 63-72.
[15]	P. K. Bowen, J. Drelich, J. Goldman. Zinc exhibits ideal physiological corrosion behavior for bio absorbable stents [J]. Advanced materials, 2013, 25 (18): 2577-2582.
[16]	H. F. Li, X. H. Xie, Y. F. Zheng, et al. Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr [J]. Scientific Reports, 2015, 5: 10719-10727.
[17]	M. T. Rubino, M. Agamennone, C. Campestre, et al. Cover Picture: Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption [J]. Chemmedchem, 2011, 6 (7): 1258-1268.
[18]	M. Yamaguchi. Role of zinc in bone formation and bone resorption [J]. The Journal of Trace Elements in Experimental Medicine, 1998, 2-3: 119-135.
[19]	C. J. Frederickson, J. Y. Koh, A. I. Bush. The neurobiology of zinc in health and disease [J]. Nature reviews. Neuroscience, 2005, 6 (6): 449-462.
[20]	R. Erbel, C. D. Mario, J. Bartunek, et al. Temporary scaffolding of coronary arteries with bio absorbable magnesium stents: A prospective, non-randomized multicenter trial [J]. Journal of Endovascular Therapy, 2005, 5: 1-5.
[21]	M. D. Pereda, C. Alonso, L. B. Asperilla, et al. Corrosion inhibition of powder metallurgy Mg by fluoride treatments [J]. Acta Biomaterialia, 2010, 6 (5): 1772-1782.
[22]	C. Y. Zhao, F. S. Pan, S. Zhao, et al. Microstructure, corrosion behavior and cytotoxicity of biodegradable Mg-Sn implant alloys prepared by sub-rapid solidification [J]. Materials Science and Engineering: C, 2015, 54: 245-251.
[23]	J. G. Kim, Y. W. Kim. Advanced Mg-Mn-Ca sacrificial anode materials for cathodic protection [J]. Materials and Corrosion, 2001, 52: 137-139.
[24]	N. Hort, Y. Huang, D. Fechner, et al. Magnesium alloys as implant materials – Principles of property design for Mg–RE alloys [J]. Acta Biomaterialia, 2010, 6 (5): 1714-1725.
[25]	F. Witte, V. Kaese, H. Haferkamp, et al. In vivo corrosion of four magnesium alloys and the associated bone response [J]. Biomaterials, 2005, 26 (17): 3557-3563.
[26]	P. Wan, L. Tan, K. Yang. Surface Modification on Biodegradable Magnesium Alloys as Orthopedic Implant Materials to Improve the Bio-adaptability: A Review [J]. Journal of Materials Science and Technology, 2016, 32 (9): 827-834.
[27]	J. Z. Ilich, J. E. Kerstetter. Nutrition in Bone Health Revisited: A Story Beyond Calcium [J]. Journal of the American College of Nutrition, 2000, 19 (6): 715-737.
[28]	A. Drynda, T. Hassel, R. Hoehn, et al. Development and biocompatibility of a novel corrodible fluoride-coated magnesium-calcium alloy with improved degradation kinetics and adequate mechanical properties for cardiovascular applications [J]. Journal of Biomedical Materials Research, 2010, 93 (2): 763-775.
[29]	A. Krause, N. V. D. Hoh, D. Bormann, et al. Degradation behavior and mechanical properties of magnesium implants in rabbit tibiae [J]. Journal of Materials Science, 2010, 45 (3): 624-632.
[30]	Wei Simin, Wang Yinghui, Tang Zhishu, et al. Novel biosynthesis method of silver nanoparticle by UV radiation of Cornus Officinalis Aqueous Extract and Biological Activities [J]. Chemical Journal of Chinese Universities, 2020, 41 (6): 1391-1398.
[31]	Wang Yan, Qin Shexuan, Shao Yongzhen, et al. The inhibitory effect and mechanism of silver nanoparticles on three kinds of microbes in vitro [J]. Chinese Journal of Microecol, 2018, 30 (1): 39-42.
[32]	Dong Limin, Nie Tongying, Hu Xinxin, et al. The antibacterial activity of nanosilver against bacteria for dental root canal disinfection [J]. Chinese Journal of Antibiotics, 2017, 42 (3): S2-S7.
[33]	Liu Jun. Preparation of silver nanoparticles gelatin/alginate scaffold and experimental study of repairing skull defect [D]. China Medical University, Master Degree Thesis, 2020: 3-17.
[34]	Wu Maojiang. The relationship between strontium and human health [J]. Studies of Trace Elements and Health, 2012, 29 (5): 66-67.
[35]	Wang Maiquan, Li Yunfeng. Trace element strontium and osteoporosis [J]. Chinese Journal of Osteoporos, 2014, 20 (10): 1258-1262.
[36]	H. S. Brar, J. Wong, M. V. Manuel. Investigation of the mechanical and degradation properties of Mg–Sr and Mg–Zn–Sr alloys for use as potential biodegradable implant materials [J] Journal of the Mechanical Behavior of Biomedical Materials, 2012, 7: 87-95.
[37]	Zhou Gongyao, Qu Gongqi, Gong Haibo. A high strength and toughness zinc-magnesium alloy implant material with corrosion resistance which can be absorbed by human body [P]. Chinese Patent: 201410101607.9, 2014-03-19.
[38]	Cui Zeqin, Luo Mengda, Zhang Yakai, et al. A preparation method of Zinc-magnesium alloy with core-shell structure [P]. China Patent: 201910540989.8, 2019-06-21.
[39]	Gu Chenxi, Li Yu, Xu Jianzhong, et al. A bimetal material for medical implantation and its preparation method [P]. China Patent: 201810865875.6, 2018-08-01.
[40]	Gu Xuannan, Chen Kai, Wang Yifan, et al. A microalloyed medical antibacterial Zn-Mg-Ag alloy and its preparation method [P]. China Patent: 202010772208.0, 2020-12-15.
[41]	Shen Chao. Mechanical properties, biodegradation and biocompatibility evaluation of biodegradable Zn-1.2Mg-0.1Ca alloy for medical application [J]. Fourth Military Medical University, Doctoral Dissertation, 2017: 26-77.
[42]	Bai Jing, Li Yang, Xu Yan, et al. A preparation method of as-cast zinc based material with ordered porous for biomedical purposes [P]. China Patent: 201910399167.2, 2020-12-15.
[43]	Cao Yating, Yao Yao, Li Junfei, et al. An alloy material and its application [P]. China Patent: 201510981436.8, 2015-12-23.
[44]	Liu Fang. Mechanical and corrosion resistanceproperties of Zn-Sr biodegradable medical materials [D]. Wuhan University of Science and Technology, Master Degree Thesis, 2018: 10-46.

Cite This Article

Plain Text BibTeX RIS

APA Style

Wang Heng, Yang Kang, Ma Yiming, Xu Lin. (2023). Research Progress on Biodegradable Zn-Based Alloy Materials. American Journal of Life Sciences, 11(4), 56-63. https://doi.org/10.11648/j.ajls.20231104.12

Copy | Download

ACS Style

Wang Heng; Yang Kang; Ma Yiming; Xu Lin. Research Progress on Biodegradable Zn-Based Alloy Materials. Am. J. Life Sci. 2023, 11(4), 56-63. doi: 10.11648/j.ajls.20231104.12

Copy | Download

AMA Style

Wang Heng, Yang Kang, Ma Yiming, Xu Lin. Research Progress on Biodegradable Zn-Based Alloy Materials. Am J Life Sci. 2023;11(4):56-63. doi: 10.11648/j.ajls.20231104.12

Copy | Download

@article{10.11648/j.ajls.20231104.12,
  author = {Wang Heng and Yang Kang and Ma Yiming and Xu Lin},
  title = {Research Progress on Biodegradable Zn-Based Alloy Materials},
  journal = {American Journal of Life Sciences},
  volume = {11},
  number = {4},
  pages = {56-63},
  doi = {10.11648/j.ajls.20231104.12},
  url = {https://doi.org/10.11648/j.ajls.20231104.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20231104.12},
  abstract = {As biodegradable materials for biomedical purposes, people have done a lot of research on Mg alloy and Fe alloy. However, both types of materials have obvious shortcomings. Mg alloy degrades too rapid and the inhomogeneity degradation rate in the human environment, resulting in its mechanical properties rapidly declining and it cannot provide adequate support or fixing capacity. Fe alloy has a very slow degradation rate due to the good protective effect of its degradation products, resulting in similar problems to non-degradable material. In this situation, Zn alloys are often mentioned in recent years, because Zn is an essential trace element for the human body, and the standard potential of Zn is between Mg and Fe, so its degradation rate is excellent. At the same time, Zn-based alloy has become a new biodegradable biomedical material after Mg alloy and Fe alloy, and has been widely used in cardiovascular stents, bone implants and internal fixation devices, and gastrointestinal staplers. At present, there is no systematic research result on biodegradable biomedical Zn-based Alloy Materials, the research interests include composition design, processing and preparation, degradation principle, biocompatibility, mechanical properties in all aspects. This article reviewed the properties of Zn-based Alloy Materials compared with other typical alloys and pointed out the future development direction.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Research Progress on Biodegradable Zn-Based Alloy Materials
AU  - Wang Heng
AU  - Yang Kang
AU  - Ma Yiming
AU  - Xu Lin
Y1  - 2023/08/15
PY  - 2023
N1  - https://doi.org/10.11648/j.ajls.20231104.12
DO  - 10.11648/j.ajls.20231104.12
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 56
EP  - 63
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20231104.12
AB  - As biodegradable materials for biomedical purposes, people have done a lot of research on Mg alloy and Fe alloy. However, both types of materials have obvious shortcomings. Mg alloy degrades too rapid and the inhomogeneity degradation rate in the human environment, resulting in its mechanical properties rapidly declining and it cannot provide adequate support or fixing capacity. Fe alloy has a very slow degradation rate due to the good protective effect of its degradation products, resulting in similar problems to non-degradable material. In this situation, Zn alloys are often mentioned in recent years, because Zn is an essential trace element for the human body, and the standard potential of Zn is between Mg and Fe, so its degradation rate is excellent. At the same time, Zn-based alloy has become a new biodegradable biomedical material after Mg alloy and Fe alloy, and has been widely used in cardiovascular stents, bone implants and internal fixation devices, and gastrointestinal staplers. At present, there is no systematic research result on biodegradable biomedical Zn-based Alloy Materials, the research interests include composition design, processing and preparation, degradation principle, biocompatibility, mechanical properties in all aspects. This article reviewed the properties of Zn-based Alloy Materials compared with other typical alloys and pointed out the future development direction.
VL  - 11
IS  - 4
ER  -

Copy | Download

Author Information

Wang Heng

Suzhou Xiangguan Alloy Research Institute Ltd., Suzhou, China
Yang Kang

Suzhou Xiangguan Alloy Research Institute Ltd., Suzhou, China
Ma Yiming

Suzhou Xiangguan Alloy Research Institute Ltd., Suzhou, China
Xu Lin

Suzhou Xiangguan Alloy Research Institute Ltd., Suzhou, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Wang Heng, Yang Kang, Ma Yiming, Xu Lin. (2023). Research Progress on Biodegradable Zn-Based Alloy Materials. American Journal of Life Sciences, 11(4), 56-63. https://doi.org/10.11648/j.ajls.20231104.12

Copy | Download

ACS Style

Wang Heng; Yang Kang; Ma Yiming; Xu Lin. Research Progress on Biodegradable Zn-Based Alloy Materials. Am. J. Life Sci. 2023, 11(4), 56-63. doi: 10.11648/j.ajls.20231104.12

Copy | Download

AMA Style

Wang Heng, Yang Kang, Ma Yiming, Xu Lin. Research Progress on Biodegradable Zn-Based Alloy Materials. Am J Life Sci. 2023;11(4):56-63. doi: 10.11648/j.ajls.20231104.12

Copy | Download

@article{10.11648/j.ajls.20231104.12,
  author = {Wang Heng and Yang Kang and Ma Yiming and Xu Lin},
  title = {Research Progress on Biodegradable Zn-Based Alloy Materials},
  journal = {American Journal of Life Sciences},
  volume = {11},
  number = {4},
  pages = {56-63},
  doi = {10.11648/j.ajls.20231104.12},
  url = {https://doi.org/10.11648/j.ajls.20231104.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20231104.12},
  abstract = {As biodegradable materials for biomedical purposes, people have done a lot of research on Mg alloy and Fe alloy. However, both types of materials have obvious shortcomings. Mg alloy degrades too rapid and the inhomogeneity degradation rate in the human environment, resulting in its mechanical properties rapidly declining and it cannot provide adequate support or fixing capacity. Fe alloy has a very slow degradation rate due to the good protective effect of its degradation products, resulting in similar problems to non-degradable material. In this situation, Zn alloys are often mentioned in recent years, because Zn is an essential trace element for the human body, and the standard potential of Zn is between Mg and Fe, so its degradation rate is excellent. At the same time, Zn-based alloy has become a new biodegradable biomedical material after Mg alloy and Fe alloy, and has been widely used in cardiovascular stents, bone implants and internal fixation devices, and gastrointestinal staplers. At present, there is no systematic research result on biodegradable biomedical Zn-based Alloy Materials, the research interests include composition design, processing and preparation, degradation principle, biocompatibility, mechanical properties in all aspects. This article reviewed the properties of Zn-based Alloy Materials compared with other typical alloys and pointed out the future development direction.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Research Progress on Biodegradable Zn-Based Alloy Materials
AU  - Wang Heng
AU  - Yang Kang
AU  - Ma Yiming
AU  - Xu Lin
Y1  - 2023/08/15
PY  - 2023
N1  - https://doi.org/10.11648/j.ajls.20231104.12
DO  - 10.11648/j.ajls.20231104.12
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 56
EP  - 63
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20231104.12
AB  - As biodegradable materials for biomedical purposes, people have done a lot of research on Mg alloy and Fe alloy. However, both types of materials have obvious shortcomings. Mg alloy degrades too rapid and the inhomogeneity degradation rate in the human environment, resulting in its mechanical properties rapidly declining and it cannot provide adequate support or fixing capacity. Fe alloy has a very slow degradation rate due to the good protective effect of its degradation products, resulting in similar problems to non-degradable material. In this situation, Zn alloys are often mentioned in recent years, because Zn is an essential trace element for the human body, and the standard potential of Zn is between Mg and Fe, so its degradation rate is excellent. At the same time, Zn-based alloy has become a new biodegradable biomedical material after Mg alloy and Fe alloy, and has been widely used in cardiovascular stents, bone implants and internal fixation devices, and gastrointestinal staplers. At present, there is no systematic research result on biodegradable biomedical Zn-based Alloy Materials, the research interests include composition design, processing and preparation, degradation principle, biocompatibility, mechanical properties in all aspects. This article reviewed the properties of Zn-based Alloy Materials compared with other typical alloys and pointed out the future development direction.
VL  - 11
IS  - 4
ER  -

Copy | Download