Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis

Ivana Filipovic; Olivera Ostojic; Vesna Vekovic; Sladjana Mihajlovic; Marco Caminati; Zorica Zivkovic

doi:doi:10.11648/j.ajp.20230904.11

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Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Sladjana Mihajlovic, Marco Caminati, Zorica Zivkovic

Published in American Journal of Pediatrics (Volume 9, Issue 4)

Received: 5 September 2023 Accepted: 25 September 2023 Published: 8 October 2023

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Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 10⁹CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.

Published in	American Journal of Pediatrics (Volume 9, Issue 4)
DOI	10.11648/j.ajp.20230904.11
Page(s)	186-192
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Children, Atopic Dermatitis, Probiotics

References

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[15]	Neri I, Galli E, Baiardini I, Picozza M, Rossi AB, Matruglio P, et al. Implications of atopic dermatitis on the quality of life of 6-11 years old children and caregivers (PEDI-BURDEN). J Asthma Allergy. 2023; 16: 383-96.
[16]	Fasseeh AN, Elezbawy B, Korra N, Tannira M, Dalle H, Aderian S, et al. Burden of atopic dermatitis in adults and adolescents: a systematic literature review. Dermatol Ther (Heidelb). 2022; 12 (12): 2653-68.
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[23]	Filipovic I, Ostojic O, Vekovic V, Lackovic M, Zivkovic Z, Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy, American Journal of Pediatrics. 2020; 6 (3): 280-284. doi: 10.11648/j.ajp.20200603.26.
[24]	Zivkovic Z, VekovicV, Jocic-Stojanovi J, Filipovic I, Caminati M, Korcok D, Mitrovic S and Ostojic O. Visual Analog Scale-An easy Method of Cough Assessment in Children. EC Pulmonology and Respiratory Medicine 2019; 8.11: 82-91.
[25]	Filipovic I, Lackovic M, Mihajlovic M, Bakic T, Filipovic Đ and Zivkovic Z. Probiotics in allergic diseases. In the book: Atopic Dermatitis (ISBN 978-1-83962-724-8) InTech, Published: September 16th 2020. DOI: 10.5772/intechopen.93535.
[26]	I. Filipović, M. Lacković, I. Plješa, S. Mihajlović, Z. Živković,, et at Uloga probiotika u primarnoj prevenciji atopijskih bolesti - Kad je pravo vreme? Prev Ped, 2021; 7 (1-2): 27–30.

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APA Style

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Sladjana Mihajlovic, Marco Caminati, et al. (2023). Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. American Journal of Pediatrics, 9(4), 186-192. https://doi.org/10.11648/j.ajp.20230904.11

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ACS Style

Ivana Filipovic; Olivera Ostojic; Vesna Vekovic; Sladjana Mihajlovic; Marco Caminati, et al. Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. Am. J. Pediatr. 2023, 9(4), 186-192. doi: 10.11648/j.ajp.20230904.11

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AMA Style

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Sladjana Mihajlovic, Marco Caminati, et al. Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. Am J Pediatr. 2023;9(4):186-192. doi: 10.11648/j.ajp.20230904.11

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@article{10.11648/j.ajp.20230904.11,
  author = {Ivana Filipovic and Olivera Ostojic and Vesna Vekovic and Sladjana Mihajlovic and Marco Caminati and Zorica Zivkovic},
  title = {Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis},
  journal = {American Journal of Pediatrics},
  volume = {9},
  number = {4},
  pages = {186-192},
  doi = {10.11648/j.ajp.20230904.11},
  url = {https://doi.org/10.11648/j.ajp.20230904.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230904.11},
  abstract = {Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.},
 year = {2023}
}

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TY  - JOUR
T1  - Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis
AU  - Ivana Filipovic
AU  - Olivera Ostojic
AU  - Vesna Vekovic
AU  - Sladjana Mihajlovic
AU  - Marco Caminati
AU  - Zorica Zivkovic
Y1  - 2023/10/08
PY  - 2023
N1  - https://doi.org/10.11648/j.ajp.20230904.11
DO  - 10.11648/j.ajp.20230904.11
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 186
EP  - 192
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20230904.11
AB  - Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.
VL  - 9
IS  - 4
ER  -

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Author Information

Ivana Filipovic

Hospital for Gynecology and Obstetrics - Neonatology Department, University Hospital dr Dragisa Misovic, Begrade, Serbia
Olivera Ostojic

Children’s Hospital for Lung Diseases and Tb, University Hospital dr Dragisa Misovic, Belgrade, Serbia
Vesna Vekovic

Children’s Hospital for Lung Diseases and Tb, University Hospital dr Dragisa Misovic, Belgrade, Serbia
Sladjana Mihajlovic

Hospital for Gynecology and Obstetrics - Neonatology Department, University Hospital dr Dragisa Misovic, Begrade, Serbia
Marco Caminati

Department of Medicine, Allergy Unit and Asthma Center, University of Verona, Verona, Italy
Zorica Zivkovic

Children’s Hospital for Lung Diseases and Tb, University Hospital dr Dragisa Misovic, Belgrade, Serbia

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Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Sladjana Mihajlovic, Marco Caminati, et al. (2023). Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. American Journal of Pediatrics, 9(4), 186-192. https://doi.org/10.11648/j.ajp.20230904.11

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ACS Style

Ivana Filipovic; Olivera Ostojic; Vesna Vekovic; Sladjana Mihajlovic; Marco Caminati, et al. Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. Am. J. Pediatr. 2023, 9(4), 186-192. doi: 10.11648/j.ajp.20230904.11

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AMA Style

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Sladjana Mihajlovic, Marco Caminati, et al. Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. Am J Pediatr. 2023;9(4):186-192. doi: 10.11648/j.ajp.20230904.11

Copy | Download

@article{10.11648/j.ajp.20230904.11,
  author = {Ivana Filipovic and Olivera Ostojic and Vesna Vekovic and Sladjana Mihajlovic and Marco Caminati and Zorica Zivkovic},
  title = {Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis},
  journal = {American Journal of Pediatrics},
  volume = {9},
  number = {4},
  pages = {186-192},
  doi = {10.11648/j.ajp.20230904.11},
  url = {https://doi.org/10.11648/j.ajp.20230904.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230904.11},
  abstract = {Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis
AU  - Ivana Filipovic
AU  - Olivera Ostojic
AU  - Vesna Vekovic
AU  - Sladjana Mihajlovic
AU  - Marco Caminati
AU  - Zorica Zivkovic
Y1  - 2023/10/08
PY  - 2023
N1  - https://doi.org/10.11648/j.ajp.20230904.11
DO  - 10.11648/j.ajp.20230904.11
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 186
EP  - 192
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20230904.11
AB  - Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.
VL  - 9
IS  - 4
ER  -

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