Although numerous studies have investigated the interaction between nanoparticles and biological systems (proteins, cells, tissues, membrane etc.), and the growing interests of nanotoxicity of these engineered nanoparticles, much remains to be investigated. First, there are various factors to be explored, such as the physical or chemical properties of materials, different cell lines, and the systematic study of specific materials. Secondly, architectural structure (shape) conditions of NPs have not been well investigated and undestood. Third, the variations in cell line result in different cell uptake, toxicity, or transportation in the same materials, but systematic studies of this phenomenon are scanty. Fourth, the nanotoxicity issue and the accumulation of non-degradable materials relating to biosafety are yet to be understood. Fifth, the transformation of NMs’ surface chemistry in living creatures is too complicated to investigate. In this article, we review the biophysicochemical mechanisms of the various interactions between nanomaterials and biological systems (proteins, cells, membrane). With the rapid increase in studies related to nanotechnology, investigations on nanomaterials can be more beneficial than others because of their size. A comprehensive understanding of nano-bio interactions can serve as a foundation for future biomedical applications.
| Published in | European Journal of Biophysics (Volume 5, Issue 4) |
| DOI | 10.11648/j.ejb.20170504.12 |
| Page(s) | 66-78 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
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APA Style
Louis Hitler, Maraga Tonny Nyong’a, Israt Ali, Ahmed Sadia, Kibaba Paul Waliaula, et al. (2017). Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review. European Journal of Biophysics, 5(4), 66-78. https://doi.org/10.11648/j.ejb.20170504.12
ACS Style
Louis Hitler; Maraga Tonny Nyong’a; Israt Ali; Ahmed Sadia; Kibaba Paul Waliaula, et al. Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review. Eur. J. Biophys. 2017, 5(4), 66-78. doi: 10.11648/j.ejb.20170504.12
AMA Style
Louis Hitler, Maraga Tonny Nyong’a, Israt Ali, Ahmed Sadia, Kibaba Paul Waliaula, et al. Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review. Eur J Biophys. 2017;5(4):66-78. doi: 10.11648/j.ejb.20170504.12
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Download@article{10.11648/j.ejb.20170504.12,
author = {Louis Hitler and Maraga Tonny Nyong’a and Israt Ali and Ahmed Sadia and Kibaba Paul Waliaula and Okoth Joseph Ogalo and Akakuru Ozioma Udochukwu},
title = {Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review},
journal = {European Journal of Biophysics},
volume = {5},
number = {4},
pages = {66-78},
doi = {10.11648/j.ejb.20170504.12},
url = {https://doi.org/10.11648/j.ejb.20170504.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejb.20170504.12},
abstract = {Although numerous studies have investigated the interaction between nanoparticles and biological systems (proteins, cells, tissues, membrane etc.), and the growing interests of nanotoxicity of these engineered nanoparticles, much remains to be investigated. First, there are various factors to be explored, such as the physical or chemical properties of materials, different cell lines, and the systematic study of specific materials. Secondly, architectural structure (shape) conditions of NPs have not been well investigated and undestood. Third, the variations in cell line result in different cell uptake, toxicity, or transportation in the same materials, but systematic studies of this phenomenon are scanty. Fourth, the nanotoxicity issue and the accumulation of non-degradable materials relating to biosafety are yet to be understood. Fifth, the transformation of NMs’ surface chemistry in living creatures is too complicated to investigate. In this article, we review the biophysicochemical mechanisms of the various interactions between nanomaterials and biological systems (proteins, cells, membrane). With the rapid increase in studies related to nanotechnology, investigations on nanomaterials can be more beneficial than others because of their size. A comprehensive understanding of nano-bio interactions can serve as a foundation for future biomedical applications.},
year = {2017}
}
TY - JOUR T1 - Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review AU - Louis Hitler AU - Maraga Tonny Nyong’a AU - Israt Ali AU - Ahmed Sadia AU - Kibaba Paul Waliaula AU - Okoth Joseph Ogalo AU - Akakuru Ozioma Udochukwu Y1 - 2017/12/18 PY - 2017 N1 - https://doi.org/10.11648/j.ejb.20170504.12 DO - 10.11648/j.ejb.20170504.12 T2 - European Journal of Biophysics JF - European Journal of Biophysics JO - European Journal of Biophysics SP - 66 EP - 78 PB - Science Publishing Group SN - 2329-1737 UR - https://doi.org/10.11648/j.ejb.20170504.12 AB - Although numerous studies have investigated the interaction between nanoparticles and biological systems (proteins, cells, tissues, membrane etc.), and the growing interests of nanotoxicity of these engineered nanoparticles, much remains to be investigated. First, there are various factors to be explored, such as the physical or chemical properties of materials, different cell lines, and the systematic study of specific materials. Secondly, architectural structure (shape) conditions of NPs have not been well investigated and undestood. Third, the variations in cell line result in different cell uptake, toxicity, or transportation in the same materials, but systematic studies of this phenomenon are scanty. Fourth, the nanotoxicity issue and the accumulation of non-degradable materials relating to biosafety are yet to be understood. Fifth, the transformation of NMs’ surface chemistry in living creatures is too complicated to investigate. In this article, we review the biophysicochemical mechanisms of the various interactions between nanomaterials and biological systems (proteins, cells, membrane). With the rapid increase in studies related to nanotechnology, investigations on nanomaterials can be more beneficial than others because of their size. A comprehensive understanding of nano-bio interactions can serve as a foundation for future biomedical applications. VL - 5 IS - 4 ER -
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