Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Brain Cortex Tissues

Lilia Narinyan; Sinerik Ayrapetyan

doi:doi:10.11648/j.ejb.20190702.11

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Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na⁺/Ca²⁺ Exchanger in Brain Cortex Tissues

Lilia Narinyan, Sinerik Ayrapetyan

Published in European Journal of Biophysics (Volume 7, Issue 2)

Received: 19 July 2019 Accepted: 15 August 2019 Published: 29 August 2019

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Abstract

The cognitive function of brain and contractility of heart muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and heart muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na⁺/K⁺ pump and activation of Na⁺/Ca²⁺ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and heart muscle tissues has different nature. The age-dependent dysfunction of Na⁺/K⁺ pump–induced activation of RNa⁺/Ca²⁺ exchange leads to dysfunction of heart muscle contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa⁺/Ca²⁺ exchange induced muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na⁺/Ca²⁺ exchanger in the membrane.

Published in	European Journal of Biophysics (Volume 7, Issue 2)
DOI	10.11648/j.ejb.20190702.11
Page(s)	27-42
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Hydration, Brain Cortex, Heart Muscle, [³H]-Ouabain, Na⁺/K⁺ Pump

References

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APA Style

Lilia Narinyan, Sinerik Ayrapetyan. (2019). Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues. European Journal of Biophysics, 7(2), 27-42. https://doi.org/10.11648/j.ejb.20190702.11

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ACS Style

Lilia Narinyan; Sinerik Ayrapetyan. Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues. Eur. J. Biophys. 2019, 7(2), 27-42. doi: 10.11648/j.ejb.20190702.11

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AMA Style

Lilia Narinyan, Sinerik Ayrapetyan. Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues. Eur J Biophys. 2019;7(2):27-42. doi: 10.11648/j.ejb.20190702.11

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@article{10.11648/j.ejb.20190702.11,
  author = {Lilia Narinyan and Sinerik Ayrapetyan},
  title = {Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues},
  journal = {European Journal of Biophysics},
  volume = {7},
  number = {2},
  pages = {27-42},
  doi = {10.11648/j.ejb.20190702.11},
  url = {https://doi.org/10.11648/j.ejb.20190702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejb.20190702.11},
  abstract = {The cognitive function of brain and contractility of heart muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and heart muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and heart muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of heart muscle contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.},
 year = {2019}
}

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TY  - JOUR
T1  - Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues
AU  - Lilia Narinyan
AU  - Sinerik Ayrapetyan
Y1  - 2019/08/29
PY  - 2019
N1  - https://doi.org/10.11648/j.ejb.20190702.11
DO  - 10.11648/j.ejb.20190702.11
T2  - European Journal of Biophysics
JF  - European Journal of Biophysics
JO  - European Journal of Biophysics
SP  - 27
EP  - 42
PB  - Science Publishing Group
SN  - 2329-1737
UR  - https://doi.org/10.11648/j.ejb.20190702.11
AB  - The cognitive function of brain and contractility of heart muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and heart muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and heart muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of heart muscle contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.
VL  - 7
IS  - 2
ER  -

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Author Information

Lilia Narinyan

Life Sciences International Postgraduate Educational Center, Unesco Chair in Life Sciences, Yerevan, Armenia
Sinerik Ayrapetyan

Life Sciences International Postgraduate Educational Center, Unesco Chair in Life Sciences, Yerevan, Armenia

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Plain Text BibTeX RIS

APA Style

Lilia Narinyan, Sinerik Ayrapetyan. (2019). Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues. European Journal of Biophysics, 7(2), 27-42. https://doi.org/10.11648/j.ejb.20190702.11

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ACS Style

Lilia Narinyan; Sinerik Ayrapetyan. Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues. Eur. J. Biophys. 2019, 7(2), 27-42. doi: 10.11648/j.ejb.20190702.11

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AMA Style

Lilia Narinyan, Sinerik Ayrapetyan. Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues. Eur J Biophys. 2019;7(2):27-42. doi: 10.11648/j.ejb.20190702.11

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@article{10.11648/j.ejb.20190702.11,
  author = {Lilia Narinyan and Sinerik Ayrapetyan},
  title = {Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues},
  journal = {European Journal of Biophysics},
  volume = {7},
  number = {2},
  pages = {27-42},
  doi = {10.11648/j.ejb.20190702.11},
  url = {https://doi.org/10.11648/j.ejb.20190702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejb.20190702.11},
  abstract = {The cognitive function of brain and contractility of heart muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and heart muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and heart muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of heart muscle contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues
AU  - Lilia Narinyan
AU  - Sinerik Ayrapetyan
Y1  - 2019/08/29
PY  - 2019
N1  - https://doi.org/10.11648/j.ejb.20190702.11
DO  - 10.11648/j.ejb.20190702.11
T2  - European Journal of Biophysics
JF  - European Journal of Biophysics
JO  - European Journal of Biophysics
SP  - 27
EP  - 42
PB  - Science Publishing Group
SN  - 2329-1737
UR  - https://doi.org/10.11648/j.ejb.20190702.11
AB  - The cognitive function of brain and contractility of heart muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and heart muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and heart muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of heart muscle contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.
VL  - 7
IS  - 2
ER  -

Copy | Download