This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing nanoparticles composed of hydroxyapatite were obtained by a process of nanoprecipitation. Pickering oil-in-water emulsions stabilized with hydroxyapatite nanoparticles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of hydroxyapatite nanoparticles on the physicochemical properties of Pickering emulsions. The system was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by hydroxyapatite nanoparticles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and hydroxyapatite nanoparticles have advantage of being biocompatible because having the same mineral composition as bones and teeth. In addition, they allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.
| Published in | European Journal of Biophysics (Volume 8, Issue 2) |
| DOI | 10.11648/j.ejb.20200802.16 |
| Page(s) | 52-59 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Emulsion, Pickering, Nanoparticles, Hydroxyapatite, Oral Bioavailability
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APA Style
Papa Mady Sy, Louis Augustin Diaga Diouf, Alphonse Rodrigue Djiboune, Sidy Mouhamed Dieng, Mamadou Soumboundou, et al. (2020). pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study. European Journal of Biophysics, 8(2), 52-59. https://doi.org/10.11648/j.ejb.20200802.16
ACS Style
Papa Mady Sy; Louis Augustin Diaga Diouf; Alphonse Rodrigue Djiboune; Sidy Mouhamed Dieng; Mamadou Soumboundou, et al. pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study. Eur. J. Biophys. 2020, 8(2), 52-59. doi: 10.11648/j.ejb.20200802.16
AMA Style
Papa Mady Sy, Louis Augustin Diaga Diouf, Alphonse Rodrigue Djiboune, Sidy Mouhamed Dieng, Mamadou Soumboundou, et al. pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study. Eur J Biophys. 2020;8(2):52-59. doi: 10.11648/j.ejb.20200802.16
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Download@article{10.11648/j.ejb.20200802.16,
author = {Papa Mady Sy and Louis Augustin Diaga Diouf and Alphonse Rodrigue Djiboune and Sidy Mouhamed Dieng and Mamadou Soumboundou and Cecile Diop and Toro Diop and Gora Mbaye and Mamadou Mbodj and Mounibe Diarra},
title = {pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study},
journal = {European Journal of Biophysics},
volume = {8},
number = {2},
pages = {52-59},
doi = {10.11648/j.ejb.20200802.16},
url = {https://doi.org/10.11648/j.ejb.20200802.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejb.20200802.16},
abstract = {This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing nanoparticles composed of hydroxyapatite were obtained by a process of nanoprecipitation. Pickering oil-in-water emulsions stabilized with hydroxyapatite nanoparticles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of hydroxyapatite nanoparticles on the physicochemical properties of Pickering emulsions. The system was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by hydroxyapatite nanoparticles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and hydroxyapatite nanoparticles have advantage of being biocompatible because having the same mineral composition as bones and teeth. In addition, they allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.},
year = {2020}
}
TY - JOUR T1 - pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study AU - Papa Mady Sy AU - Louis Augustin Diaga Diouf AU - Alphonse Rodrigue Djiboune AU - Sidy Mouhamed Dieng AU - Mamadou Soumboundou AU - Cecile Diop AU - Toro Diop AU - Gora Mbaye AU - Mamadou Mbodj AU - Mounibe Diarra Y1 - 2020/11/19 PY - 2020 N1 - https://doi.org/10.11648/j.ejb.20200802.16 DO - 10.11648/j.ejb.20200802.16 T2 - European Journal of Biophysics JF - European Journal of Biophysics JO - European Journal of Biophysics SP - 52 EP - 59 PB - Science Publishing Group SN - 2329-1737 UR - https://doi.org/10.11648/j.ejb.20200802.16 AB - This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing nanoparticles composed of hydroxyapatite were obtained by a process of nanoprecipitation. Pickering oil-in-water emulsions stabilized with hydroxyapatite nanoparticles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of hydroxyapatite nanoparticles on the physicochemical properties of Pickering emulsions. The system was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by hydroxyapatite nanoparticles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and hydroxyapatite nanoparticles have advantage of being biocompatible because having the same mineral composition as bones and teeth. In addition, they allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs. VL - 8 IS - 2 ER -
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