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Helium Physicochemical "Recruitment" of Pulmonary Alveols in Prevention of Alveolar Collapse and Prevention of Acute Respiratory Distress in Patients with COVID-19

Received: 18 December 2021    Accepted: 18 January 2022    Published: 23 March 2022
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Abstract

Purpose. Show value warmed up to 95°C. With helium (as part of thermogeliox) in reducing the surface tension water, including liquid and cellular fraction of blood, which normalizes the movement of erythrocytes in the capillaries and preserves the physiological function of the alveolar-capillary space, improving gas exchange in the alveoli. Materials and methods. The data of dynamics of complaints, anamnesis, clinical symptoms, results of laboratory and instrumental studies, results of pathological, pathomorphological and histological manifestations of severe coronavirus pneumonia (CVP) complicated by acute respiratory distress syndrome (ARDS) were analyzed. Results and its discussion. In the complex treatment of severe coronavirus infection (CVI), it is proposed to use the modern innovative medical technology “CIMT”, which includes the modern device “Ingalit B2–01”, inhaling regulated heated to 90–100 C respiratory gas mixture - thermogeliox, consisting of oxygen 20-30% and helium 70-80%, alternating with inhalation of the lungs surfactant with a nebulizer. It is advisable to inject the anticoagulant under the skin. It has been shown that the development of ARDS in CEP is associated with acute coronavirus alveolitis. A quick positive systemic therapeutic effect is the prevention of ARDS in patients with severe CEP when using our proposed "SIMT" is due to a number of physicochemical and physiological effects of thermal helium.

Published in European Journal of Clinical and Biomedical Sciences (Volume 8, Issue 1)
DOI 10.11648/j.ejcbs.20220801.12
Page(s) 9-14
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Marine Medicine, COVID-19, Coronavirus Infection, Coronavirus Alveolitis, Alveolar Collapse, Modern Innovative Medical Technologies, Helium "Recruitment" of Pulmonary Alveoli

References
[1] Glybochko P. V. Clinical characteristics of 1007 patients with severe SARS-CoV-2 pneumonia who needed respiratory support//Clinical Pharmacology and Therapy. 2020. T, 29, No. 2. P. 21–29. Glybochko PV.
[2] Clinical characteristics of 1007 patients with severe SARS-CoV-2 pneumonia who needed respiratory support. Clinical pharmacology and therapy, 2020, Vol. 29, No. 2, pp. 21-29 (In Russ.)].
[3] Murthy S., Charles DG, Robert AF Care for Critically Ill Patients with COVID-19//JAMA. 2020. Vol. 323 (15). R. 1499-1500. doi: 10.1001/jama.2020.3633.
[4] Omelyanovskiy V. V., Antonov A. A., Bezdenezhnykh T. P., Khachatryan G. R. Systematic review of current scientific information on the use of drugs in the treatment of new coronavirus infection COVID-19//Medical Technologies. Evaluation and selection. 2020. No. 1. P. 8–18. doi: 10.31556/2219-0678.2020.39.1.008-018. [Omelyanovsky VV, Antonov AA, Bezdenezhnykh TP, Khachatryan GR Systematic review of current scienti fi c data on the use of medicines in the treatment of new coronavirus infection COVID-19. Medical technology. Evaluation and selection, 2020, No. 1, pp. 8-18. doi: 10.31556/2219-0678.2020.39.1.008-018 (In Russ.)].
[5] Ware LB, Matthay MA The acute respiratory distress syndrome//The New England Journal of Medicine. 2000. May. Vol. 342, No. 18. P. 1334-1349. doi: 10.1056/NEJM200005043421806. PMID 10793167.
[6] Moloney ED, Evans TW Pathophysiology and pharmacological treatment of pulmonary hypertension in acute res- piratory distress syndrome (English)//Eur. Respir. J. 2003. April, Vol. 21, No. 4. P. 720-727. PMID 12762363.
[7] Crowe SM Pathogenesis. 2006.435 p.
[8] Galkin A. A., Demidova V. S. The central role of neutrophils in the pathogenesis of acute lung injury syndrome (acute respiratory distress syndrome)//Advances in modern biology. 2014. Vol. 134, No. 4, pp. 377–394. [Galkin AA, Demidova VS The central role of neutrophils in the pathogenesis of acute lung injury syndrome (acute respiratory distress syndrome). Advances in modern biology, 2014, Vol. 134, No. 4, pp. 377–394 (In Russ.)].
[9] Behrens E. M., Koretzky GA Treatment of cytokine storm syndromes. 2017.1137 p.
[10] Sinha R., Matthay MA, Calfee CS Is a "Cytokine Storm" Relevant to COVID-19? (English)//JAMA Internal Medicine. 2020.1 September. Vol. 180, iss. 9. P. 1152. doi: 10.1001/jamainternmed. 2020.3313. PMID 32602883.
[11] Sungnak W. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes//Nat. Med. 2020. Vol. 26. P. 681-687.
[12] Jackson SP, Darbousset R., Schoenwaelder SM Thromboin fl ammation: challenges of therapeutically targeting coag- ulation and other host defense mechanisms//Blood. 2019. Vol. 133. P. 906-918.
[13] Chernyaev AL, Samsonova M. Etiology, pathogenesis and pathological anatomy of diffuse alveolar injury//General resuscitation. 2000. No. 5. P. 13-16. [Chernyaev AL, Samsonova M. Etiology, pathogenesis and pathological anatomy of diffuse alveolar injury. General intensive care, 2000, No. 5, pp. 13-16 (In Russ.)].
[14] Vlasenko A. V., Evdokimov E. A., Rodionov E. P. Modern principles of hypoxia correction in ARDS of various genesis. Part 1//Bulletin of anesthesiology and resuscitation. 2020. No. 17 (3). S. 61–78. [Vlasenko AV, Evdokimov EA, Rodionov EP Modern principles of correction of hypoxia in ARDS of various Genesis. Part 1. Bulletin of anesthesiology and resuscitation, 2020, No. 17 (3) pp. 61–78 (In Russ.)]. https://doi.org/10.21292/2078-5658-2020-17-3-61-78.
[15] Dandachi D., Rodriguez-Barradas M. S. Viral pneumonia: etiologies and treatment. Abstract//J. Investig. Med. 2018 Aug. Vol. 66 (6). P. 957-965. doi: 10.1136/jim-2018–000712.
[16] Dreyfuss D., Saumon G. Ventilator-induced lung injury: lessons from experimental studies (eng.)//American Journal of Respiratory and Critical Care Medicine (eng.) Rus. 1998. January (Vol. 157, No. 1). P. 294-323. PMID 9445314.
[17] Krasnovsky V. L., Grigoriev S. P., Alekhin A. I., Potapov V. I. The use of a heated oxygen-helium mixture in the complex treatment of patients with community-acquired pneumonia//Clinical Medicine. 2013. No. 5. P. 38–41. [Krasnovsky VL, Grigoriev SP, Alyokhin AI, Potapov VI Application of a heated oxygen-helium mixture in the complex treatment of patients with community-acquired pneumonia. Clinical medicine, 2013, No. 5, pp. 38–41 (In Russ.)].
[18] Khaidarov G. G., Khaidarov A. G., Mashek A. Ch. The physical nature of the surface tension of a liquid//Bulletin of St. Petersburg University. Series 4 (Physics, Chemistry). 2011. Issue. 1. P. 3–8. [Khaydarov GG, Khaydarov AG, Mashek A. Ch. Physical nature of surface tension of a liquid. Bulletin of the Saint Petersburg University. Series 4 (Physics, chemistry), 2011, Release. 1, pp. 3–8 (In Russ.)].
[19] Khaidarov G. G. On the relationship of surface tension with the heat of vaporization//Journal of Physical Chemistry. 1983. No. 10. P. 2528–2530. [Khaydarov GG Оn the relationship of surface tension with the heat of vaporization. Journal of physical chemistry, 1983, No. 10, pp. 2528–2530 (In Russ.)].
[20] Khaidarov G. G., Khaidarov A. G., Mashek A. Ch. Influence of temperature on surface tension//Bulletin of St. Petersburg University. Series 4 (Physics, Chemistry). 2012. Issue. 1. P. 24–28. [Khaidarov GG, Khaidarov AG, Mašek AC The effect of temperature on surface tension. Bulletin of the Saint Petersburg University. Series 4 (Physics, chemistry), 2012, Release 1, pp. 24-28 (In Russ.)].
[21] Kunitsyn V. G., Mokrushnikov P. V., Panin L. E. The mechanism of erythrocyte microcirculation in the capillary bed at physiological pH shift//Bul. SB RAMS. 2007. No. 5. P. 28–30. [Kunitsyn VG, Mokrushnikov PV, Panin LE Mechanism of erythrocyte microcirculation in the capillary bed with a physiological pH shift. Byul. SO RAMS, 2007, No. 5, pp. 28-30 (In Russ.)].
[22] Shakhnovich P. G. Peripheral circulation in conditions of hypoxic and circulatory hypoxia//Bulletin of the Russian Military Medical Academy. 2016. No. 1 (53). S. 13-16. [Shakhnovich PG Peripheral blood circulation in conditions of hypoxic and circulatory hypoxia. Bulletin of the Russian military medical Academy, 2016, No. 1 (53) pp. 13-16 (In Russ.)].
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    Svistov Alexander Sergeevich, I. G. Mosyagin, Simakina Olga Evgenievna. (2022). Helium Physicochemical "Recruitment" of Pulmonary Alveols in Prevention of Alveolar Collapse and Prevention of Acute Respiratory Distress in Patients with COVID-19. European Journal of Clinical and Biomedical Sciences, 8(1), 9-14. https://doi.org/10.11648/j.ejcbs.20220801.12

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    ACS Style

    Svistov Alexander Sergeevich; I. G. Mosyagin; Simakina Olga Evgenievna. Helium Physicochemical "Recruitment" of Pulmonary Alveols in Prevention of Alveolar Collapse and Prevention of Acute Respiratory Distress in Patients with COVID-19. Eur. J. Clin. Biomed. Sci. 2022, 8(1), 9-14. doi: 10.11648/j.ejcbs.20220801.12

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    AMA Style

    Svistov Alexander Sergeevich, I. G. Mosyagin, Simakina Olga Evgenievna. Helium Physicochemical "Recruitment" of Pulmonary Alveols in Prevention of Alveolar Collapse and Prevention of Acute Respiratory Distress in Patients with COVID-19. Eur J Clin Biomed Sci. 2022;8(1):9-14. doi: 10.11648/j.ejcbs.20220801.12

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  • @article{10.11648/j.ejcbs.20220801.12,
      author = {Svistov Alexander Sergeevich and I. G. Mosyagin and Simakina Olga Evgenievna},
      title = {Helium Physicochemical "Recruitment" of Pulmonary Alveols in Prevention of Alveolar Collapse and Prevention of Acute Respiratory Distress in Patients with COVID-19},
      journal = {European Journal of Clinical and Biomedical Sciences},
      volume = {8},
      number = {1},
      pages = {9-14},
      doi = {10.11648/j.ejcbs.20220801.12},
      url = {https://doi.org/10.11648/j.ejcbs.20220801.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20220801.12},
      abstract = {Purpose. Show value warmed up to 95°C. With helium (as part of thermogeliox) in reducing the surface tension water, including liquid and cellular fraction of blood, which normalizes the movement of erythrocytes in the capillaries and preserves the physiological function of the alveolar-capillary space, improving gas exchange in the alveoli. Materials and methods. The data of dynamics of complaints, anamnesis, clinical symptoms, results of laboratory and instrumental studies, results of pathological, pathomorphological and histological manifestations of severe coronavirus pneumonia (CVP) complicated by acute respiratory distress syndrome (ARDS) were analyzed. Results and its discussion. In the complex treatment of severe coronavirus infection (CVI), it is proposed to use the modern innovative medical technology “CIMT”, which includes the modern device “Ingalit B2–01”, inhaling regulated heated to 90–100 C respiratory gas mixture - thermogeliox, consisting of oxygen 20-30% and helium 70-80%, alternating with inhalation of the lungs surfactant with a nebulizer. It is advisable to inject the anticoagulant under the skin. It has been shown that the development of ARDS in CEP is associated with acute coronavirus alveolitis. A quick positive systemic therapeutic effect is the prevention of ARDS in patients with severe CEP when using our proposed "SIMT" is due to a number of physicochemical and physiological effects of thermal helium.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Helium Physicochemical "Recruitment" of Pulmonary Alveols in Prevention of Alveolar Collapse and Prevention of Acute Respiratory Distress in Patients with COVID-19
    AU  - Svistov Alexander Sergeevich
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    AU  - Simakina Olga Evgenievna
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    DO  - 10.11648/j.ejcbs.20220801.12
    T2  - European Journal of Clinical and Biomedical Sciences
    JF  - European Journal of Clinical and Biomedical Sciences
    JO  - European Journal of Clinical and Biomedical Sciences
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    PB  - Science Publishing Group
    SN  - 2575-5005
    UR  - https://doi.org/10.11648/j.ejcbs.20220801.12
    AB  - Purpose. Show value warmed up to 95°C. With helium (as part of thermogeliox) in reducing the surface tension water, including liquid and cellular fraction of blood, which normalizes the movement of erythrocytes in the capillaries and preserves the physiological function of the alveolar-capillary space, improving gas exchange in the alveoli. Materials and methods. The data of dynamics of complaints, anamnesis, clinical symptoms, results of laboratory and instrumental studies, results of pathological, pathomorphological and histological manifestations of severe coronavirus pneumonia (CVP) complicated by acute respiratory distress syndrome (ARDS) were analyzed. Results and its discussion. In the complex treatment of severe coronavirus infection (CVI), it is proposed to use the modern innovative medical technology “CIMT”, which includes the modern device “Ingalit B2–01”, inhaling regulated heated to 90–100 C respiratory gas mixture - thermogeliox, consisting of oxygen 20-30% and helium 70-80%, alternating with inhalation of the lungs surfactant with a nebulizer. It is advisable to inject the anticoagulant under the skin. It has been shown that the development of ARDS in CEP is associated with acute coronavirus alveolitis. A quick positive systemic therapeutic effect is the prevention of ARDS in patients with severe CEP when using our proposed "SIMT" is due to a number of physicochemical and physiological effects of thermal helium.
    VL  - 8
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Author Information
  • Sergey Mironovich Kirov Military Medical Academy, St. Petersburg, Russia

  • Main Command of the Navy, St. Petersburg, Russia

  • Institute of Experimental Medicine, St. Petersburg, Russia

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