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Fetiform Teratoma (Homunculus) Coexist with Intrauterine Foetus: A Case Report

Received: 27 January 2022    Accepted: 17 March 2022    Published: 29 March 2022
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Abstract

Fetiform teratoma is also known as a homunculus, a rare form of mature cystic teratoma with a good prognosis. We report a case of fetiform teratoma that coexist with a female neonate in a 27-year-old woman. She presented with 2 days history of abdominal pain and generalized body weakness of 3 days at 38 weeks gestation. On clinical examination, gravid enlarged uterus with twin foetus palpated on a transverse lie and imminent foetal distress. Emergency Ultrasound done showed twin gestation at 39 weeks +5 days. The patient underwent an emergency caesarean section delivered of a female baby with a foetus like mass attached to the palate of the live female baby by a stalk. The clinical diagnosis of parasitic twin gestation was made and the mass was sent for histopathological analysis. On gross examination, a skin bearing mass with 2 limbs buds reminiscent of homunculus without demonstrable vertebrae or bony tissue on cross-section. Histopathology analysis showed tumour tissue composed of haphazard arrangement mature tissue comprising derivative from ectoderm namely skin tissue, sebaceous gland, hair follicle, mesodermal derivative are cartilage and adipose tissue. Endodermal differentiation is intestinal glands lined by columnar epithelial cells admixed with goblets cells. In summary, a diagnosis of fetiform teratoma was made and the baby that coexisted with the mass was adequately follow-up without any complications.

Published in European Journal of Clinical and Biomedical Sciences (Volume 8, Issue 2)
DOI 10.11648/j.ejcbs.20220802.11
Page(s) 15-18
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fetiform Teratoma, Homunculus, Foetus in Foetus

References
[1] James A Greenberg, and Thomas E Clancy. Fetiform Teratoma (Homunculus). Rev Obstet Gynecol. 2008; 1 (3): 95–96.
[2] Abbott TM, Hermann WJ, Scully RE. Ovarian fetiform teratoma (homunculus) in a 9-year-old girl. Int J Gynecol Pathol. 1984; 2: 392–402.
[3] Kuno N, Kadomatsu K, Nakamura M, Miwa-Fukuchi T, Hirabayashi N, Ishizuka T. Mature Ovarian cystic teratoma with a highly differentiated homunculus: case report. Birth DefectsRes A Clin Mol Teratol. 2004; 70: 40–46.
[4] Lee YH, Kim SG, Choi SH, Kim IS, Kim SH. Ovarian mature cystic teratoma containing Homunculus: a case report. J Korean Med Sci. 2003; 18: 905–907.
[5] Miyake J, Ireland K. Ovarian mature teratoma with homunculus coexisting with an Intrauterine pregnancy. Arch Pathol Lab Med. 1986; 110: 1192–1194.
[6] Weldon-Linne CM, Rushovich AM. Benign ovarian cystic teratoma with homunculi. Obstet Gynecol. 1983; 61 (suppl 3): 88S–94S.
[7] Brand A, Alves MC, Saraiva C, et al. Fetus in fetu: diagnostic criteria and differential diagnosis, a case report and literature review. J Pediatr Surg. 2004; 39: 616–618.
[8] Thakral CL, Maji DC, Sajwani MJ. Fetus-in-fetu: a case report and review of the literature. J Pediatr Surg. 1998; 33: 1432–1434.
[9] Chen CP, Chern SR, Liu FF, Jan SW, Lee HC, Sheu JC, et al. Prenatal diagnosis, pathology, and genetic study of fetus in fetus. Prenat Diagn. 1997; 17 (1): 13-21.
[10] Wobenjo A Osawa F. Fetus in Fetu: A Case Report and Review of Literature Authors. The Annals of African Surgery. 2010; (6): 56-59.
Cite This Article
  • APA Style

    Rasheed Mumini Wemimo, Afolayan Enoch Abiodun, Nasir Abdulrasheed Adegoke, Odetayo Omolara Foluke, Abdulmajeed Abdulrafiu Ayinde. (2022). Fetiform Teratoma (Homunculus) Coexist with Intrauterine Foetus: A Case Report. European Journal of Clinical and Biomedical Sciences, 8(2), 15-18. https://doi.org/10.11648/j.ejcbs.20220802.11

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    ACS Style

    Rasheed Mumini Wemimo; Afolayan Enoch Abiodun; Nasir Abdulrasheed Adegoke; Odetayo Omolara Foluke; Abdulmajeed Abdulrafiu Ayinde. Fetiform Teratoma (Homunculus) Coexist with Intrauterine Foetus: A Case Report. Eur. J. Clin. Biomed. Sci. 2022, 8(2), 15-18. doi: 10.11648/j.ejcbs.20220802.11

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    AMA Style

    Rasheed Mumini Wemimo, Afolayan Enoch Abiodun, Nasir Abdulrasheed Adegoke, Odetayo Omolara Foluke, Abdulmajeed Abdulrafiu Ayinde. Fetiform Teratoma (Homunculus) Coexist with Intrauterine Foetus: A Case Report. Eur J Clin Biomed Sci. 2022;8(2):15-18. doi: 10.11648/j.ejcbs.20220802.11

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  • @article{10.11648/j.ejcbs.20220802.11,
      author = {Rasheed Mumini Wemimo and Afolayan Enoch Abiodun and Nasir Abdulrasheed Adegoke and Odetayo Omolara Foluke and Abdulmajeed Abdulrafiu Ayinde},
      title = {Fetiform Teratoma (Homunculus) Coexist with Intrauterine Foetus: A Case Report},
      journal = {European Journal of Clinical and Biomedical Sciences},
      volume = {8},
      number = {2},
      pages = {15-18},
      doi = {10.11648/j.ejcbs.20220802.11},
      url = {https://doi.org/10.11648/j.ejcbs.20220802.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20220802.11},
      abstract = {Fetiform teratoma is also known as a homunculus, a rare form of mature cystic teratoma with a good prognosis. We report a case of fetiform teratoma that coexist with a female neonate in a 27-year-old woman. She presented with 2 days history of abdominal pain and generalized body weakness of 3 days at 38 weeks gestation. On clinical examination, gravid enlarged uterus with twin foetus palpated on a transverse lie and imminent foetal distress. Emergency Ultrasound done showed twin gestation at 39 weeks +5 days. The patient underwent an emergency caesarean section delivered of a female baby with a foetus like mass attached to the palate of the live female baby by a stalk. The clinical diagnosis of parasitic twin gestation was made and the mass was sent for histopathological analysis. On gross examination, a skin bearing mass with 2 limbs buds reminiscent of homunculus without demonstrable vertebrae or bony tissue on cross-section. Histopathology analysis showed tumour tissue composed of haphazard arrangement mature tissue comprising derivative from ectoderm namely skin tissue, sebaceous gland, hair follicle, mesodermal derivative are cartilage and adipose tissue. Endodermal differentiation is intestinal glands lined by columnar epithelial cells admixed with goblets cells. In summary, a diagnosis of fetiform teratoma was made and the baby that coexisted with the mass was adequately follow-up without any complications.},
     year = {2022}
    }
    

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    T1  - Fetiform Teratoma (Homunculus) Coexist with Intrauterine Foetus: A Case Report
    AU  - Rasheed Mumini Wemimo
    AU  - Afolayan Enoch Abiodun
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    DO  - 10.11648/j.ejcbs.20220802.11
    T2  - European Journal of Clinical and Biomedical Sciences
    JF  - European Journal of Clinical and Biomedical Sciences
    JO  - European Journal of Clinical and Biomedical Sciences
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    EP  - 18
    PB  - Science Publishing Group
    SN  - 2575-5005
    UR  - https://doi.org/10.11648/j.ejcbs.20220802.11
    AB  - Fetiform teratoma is also known as a homunculus, a rare form of mature cystic teratoma with a good prognosis. We report a case of fetiform teratoma that coexist with a female neonate in a 27-year-old woman. She presented with 2 days history of abdominal pain and generalized body weakness of 3 days at 38 weeks gestation. On clinical examination, gravid enlarged uterus with twin foetus palpated on a transverse lie and imminent foetal distress. Emergency Ultrasound done showed twin gestation at 39 weeks +5 days. The patient underwent an emergency caesarean section delivered of a female baby with a foetus like mass attached to the palate of the live female baby by a stalk. The clinical diagnosis of parasitic twin gestation was made and the mass was sent for histopathological analysis. On gross examination, a skin bearing mass with 2 limbs buds reminiscent of homunculus without demonstrable vertebrae or bony tissue on cross-section. Histopathology analysis showed tumour tissue composed of haphazard arrangement mature tissue comprising derivative from ectoderm namely skin tissue, sebaceous gland, hair follicle, mesodermal derivative are cartilage and adipose tissue. Endodermal differentiation is intestinal glands lined by columnar epithelial cells admixed with goblets cells. In summary, a diagnosis of fetiform teratoma was made and the baby that coexisted with the mass was adequately follow-up without any complications.
    VL  - 8
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Author Information
  • Department of Anatomic Pathology, Federal Medical Centre, Birnin Kudu, Nigeria

  • Department of Pathology, University of Ilorin Teaching Hospital, Ilorin, Nigeria

  • Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Nigeria

  • Department of Radiology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria

  • Department of Pathology, Federal Medical Centre, Abeokuta, Nigeria

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