Background. Post-midsternotomy hypertrophic scars can lead to remarkable morbidities such as pigmentation alteration, pain, tenderness, induration, itching, and erythema so that they may be cosmetically and emotionally unacceptable to the patient undergoing midsternotomy. Initially, wound healing is induced rapidly with re-epithelialization, whereas tissue remodeling occurs several months later to create a regular scar. This study was undertaken to evaluate the efficacy of onion extract plus heparin versus Fluocinolone acetonide on scar formation after midsternotomy in patients who are candidates for coronary bypass graft (CABG) surgery. Materials and Methods. One hundred patients undergoing off- pump coronary artery bypass graft (CABG) surgery were randomly assigned into two groups, group A, onion extract plus heparin (n=50), and group B, flucinolone acetonide (n=50). After performing midsternotomy for accessing to intra-chest cavity, the target vessel was exposed and snared above the anastomosis site with zero to four sutures and a soft plastic snugger was applied to prevent coronary injury. A skilled surgeon sutured incisions of the midsternotomy. The topical treatments (gel) were started one week post operation. Subjects were then asked to return to cardiovascular center three months after the surgery for evaluation of their wounds and condition of their scars. The postoperative parameters such as indurations, erythema, pigmentation alteration, itching, cosmetic appearance, raised area of the incision, tenderness, sternal wound infection, and duration of incision improvement were evaluated by method of Vancouver scar scale. Results. The average age of all the patients was 63.8±11, 63±11.5 was related to fluocinolon acetonide group (FA) and 64±10 related to onion extract plus heparin group (OEH). Postoperative rise in scar area was observed in 63 cases, 28 cases (56%) in OEH and 35 cases (70%) in FA (p=0.14). Postoperative erythema and itching had not significant differences in both groups, therefore, onion extract plus heparin could not diminish these complications after open heart surgery (p>0.05). Conclusion. Onion extract plus heparin significantly decreased pigmentation alternation, duration of incision improvement, and tenderness after midsternotomy.
| Published in | International Journal of Clinical and Experimental Medical Sciences (Volume 1, Issue 3) |
| DOI | 10.11648/j.ijcems.20150103.13 |
| Page(s) | 42-45 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Onion Extract, Heparin, Hypertrophic Scars, Midsternotomy, Off-Pump CABG
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APA Style
Seyed Jalil Mirhosseini, Sadegh Ali-Hassan-Sayegh, Alireza Vahidi Mehrjardi, Maryam Hadibarhaghtalab, Seyed Mohammad Yousof Mostafavi-Pour-Manshadi, et al. (2015). Comparison Efficacy of Onion Extract plus Heparin with Flucinolone Acetonide on Midsternotomy Hypertrophic Scars Following Open Heart Surgery. International Journal of Clinical and Experimental Medical Sciences, 1(3), 42-45. https://doi.org/10.11648/j.ijcems.20150103.13
ACS Style
Seyed Jalil Mirhosseini; Sadegh Ali-Hassan-Sayegh; Alireza Vahidi Mehrjardi; Maryam Hadibarhaghtalab; Seyed Mohammad Yousof Mostafavi-Pour-Manshadi, et al. Comparison Efficacy of Onion Extract plus Heparin with Flucinolone Acetonide on Midsternotomy Hypertrophic Scars Following Open Heart Surgery. Int. J. Clin. Exp. Med. Sci. 2015, 1(3), 42-45. doi: 10.11648/j.ijcems.20150103.13
AMA Style
Seyed Jalil Mirhosseini, Sadegh Ali-Hassan-Sayegh, Alireza Vahidi Mehrjardi, Maryam Hadibarhaghtalab, Seyed Mohammad Yousof Mostafavi-Pour-Manshadi, et al. Comparison Efficacy of Onion Extract plus Heparin with Flucinolone Acetonide on Midsternotomy Hypertrophic Scars Following Open Heart Surgery. Int J Clin Exp Med Sci. 2015;1(3):42-45. doi: 10.11648/j.ijcems.20150103.13
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author = {Seyed Jalil Mirhosseini and Sadegh Ali-Hassan-Sayegh and Alireza Vahidi Mehrjardi and Maryam Hadibarhaghtalab and Seyed Mohammad Yousof Mostafavi-Pour-Manshadi and Nafiseh Naderi and Mohammad Reza Lotfaliani},
title = {Comparison Efficacy of Onion Extract plus Heparin with Flucinolone Acetonide on Midsternotomy Hypertrophic Scars Following Open Heart Surgery},
journal = {International Journal of Clinical and Experimental Medical Sciences},
volume = {1},
number = {3},
pages = {42-45},
doi = {10.11648/j.ijcems.20150103.13},
url = {https://doi.org/10.11648/j.ijcems.20150103.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20150103.13},
abstract = {Background. Post-midsternotomy hypertrophic scars can lead to remarkable morbidities such as pigmentation alteration, pain, tenderness, induration, itching, and erythema so that they may be cosmetically and emotionally unacceptable to the patient undergoing midsternotomy. Initially, wound healing is induced rapidly with re-epithelialization, whereas tissue remodeling occurs several months later to create a regular scar. This study was undertaken to evaluate the efficacy of onion extract plus heparin versus Fluocinolone acetonide on scar formation after midsternotomy in patients who are candidates for coronary bypass graft (CABG) surgery. Materials and Methods. One hundred patients undergoing off- pump coronary artery bypass graft (CABG) surgery were randomly assigned into two groups, group A, onion extract plus heparin (n=50), and group B, flucinolone acetonide (n=50). After performing midsternotomy for accessing to intra-chest cavity, the target vessel was exposed and snared above the anastomosis site with zero to four sutures and a soft plastic snugger was applied to prevent coronary injury. A skilled surgeon sutured incisions of the midsternotomy. The topical treatments (gel) were started one week post operation. Subjects were then asked to return to cardiovascular center three months after the surgery for evaluation of their wounds and condition of their scars. The postoperative parameters such as indurations, erythema, pigmentation alteration, itching, cosmetic appearance, raised area of the incision, tenderness, sternal wound infection, and duration of incision improvement were evaluated by method of Vancouver scar scale. Results. The average age of all the patients was 63.8±11, 63±11.5 was related to fluocinolon acetonide group (FA) and 64±10 related to onion extract plus heparin group (OEH). Postoperative rise in scar area was observed in 63 cases, 28 cases (56%) in OEH and 35 cases (70%) in FA (p=0.14). Postoperative erythema and itching had not significant differences in both groups, therefore, onion extract plus heparin could not diminish these complications after open heart surgery (p>0.05). Conclusion. Onion extract plus heparin significantly decreased pigmentation alternation, duration of incision improvement, and tenderness after midsternotomy.},
year = {2015}
}
TY - JOUR T1 - Comparison Efficacy of Onion Extract plus Heparin with Flucinolone Acetonide on Midsternotomy Hypertrophic Scars Following Open Heart Surgery AU - Seyed Jalil Mirhosseini AU - Sadegh Ali-Hassan-Sayegh AU - Alireza Vahidi Mehrjardi AU - Maryam Hadibarhaghtalab AU - Seyed Mohammad Yousof Mostafavi-Pour-Manshadi AU - Nafiseh Naderi AU - Mohammad Reza Lotfaliani Y1 - 2015/08/11 PY - 2015 N1 - https://doi.org/10.11648/j.ijcems.20150103.13 DO - 10.11648/j.ijcems.20150103.13 T2 - International Journal of Clinical and Experimental Medical Sciences JF - International Journal of Clinical and Experimental Medical Sciences JO - International Journal of Clinical and Experimental Medical Sciences SP - 42 EP - 45 PB - Science Publishing Group SN - 2469-8032 UR - https://doi.org/10.11648/j.ijcems.20150103.13 AB - Background. Post-midsternotomy hypertrophic scars can lead to remarkable morbidities such as pigmentation alteration, pain, tenderness, induration, itching, and erythema so that they may be cosmetically and emotionally unacceptable to the patient undergoing midsternotomy. Initially, wound healing is induced rapidly with re-epithelialization, whereas tissue remodeling occurs several months later to create a regular scar. This study was undertaken to evaluate the efficacy of onion extract plus heparin versus Fluocinolone acetonide on scar formation after midsternotomy in patients who are candidates for coronary bypass graft (CABG) surgery. Materials and Methods. One hundred patients undergoing off- pump coronary artery bypass graft (CABG) surgery were randomly assigned into two groups, group A, onion extract plus heparin (n=50), and group B, flucinolone acetonide (n=50). After performing midsternotomy for accessing to intra-chest cavity, the target vessel was exposed and snared above the anastomosis site with zero to four sutures and a soft plastic snugger was applied to prevent coronary injury. A skilled surgeon sutured incisions of the midsternotomy. The topical treatments (gel) were started one week post operation. Subjects were then asked to return to cardiovascular center three months after the surgery for evaluation of their wounds and condition of their scars. The postoperative parameters such as indurations, erythema, pigmentation alteration, itching, cosmetic appearance, raised area of the incision, tenderness, sternal wound infection, and duration of incision improvement were evaluated by method of Vancouver scar scale. Results. The average age of all the patients was 63.8±11, 63±11.5 was related to fluocinolon acetonide group (FA) and 64±10 related to onion extract plus heparin group (OEH). Postoperative rise in scar area was observed in 63 cases, 28 cases (56%) in OEH and 35 cases (70%) in FA (p=0.14). Postoperative erythema and itching had not significant differences in both groups, therefore, onion extract plus heparin could not diminish these complications after open heart surgery (p>0.05). Conclusion. Onion extract plus heparin significantly decreased pigmentation alternation, duration of incision improvement, and tenderness after midsternotomy. VL - 1 IS - 3 ER -
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