Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya

Ashraf Ahmed Ahmed; Siddig Bushra Mohamed; Salih Abdelgadir Elmadi; Abdelkarim A. Abdorabo; Ismail Mohamed Ismail; Amar Mohamed Ismail

doi:doi:10.11648/j.ijcems.20170301.11

Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya

Ashraf Ahmed Ahmed, Siddig Bushra Mohamed, Salih Abdelgadir Elmadi, Abdelkarim A. Abdorabo, Ismail Mohamed Ismail, Amar Mohamed Ismail

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 3, Issue 1)

Received: 19 February 2017 Accepted: 1 March 2017 Published: 18 April 2017

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Abstract

Diabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice. The study aim to find out the prevalence of thyroid disorders in type 2 diabetes mellitus patients. In a cross-sectional study 369 diagnosed type 2 DM patients, of which 203 are males and 166 are females, age reneged from (18 to 73) were enrolled, from July 2016 to July 2016. Their demographic data were obtained by through a questionnaire. Serum FT3, FT4, TSH and thyroid Antibodies (Tg-Ab, AM-Ab and TR-Ab) were measured using TOSOH, ELISA and enzymatic methods respectively. Out the 369 type 2 DM patients, of whom 9.5% are thyroid disorders, 2.3% have hypothyroidism, 5.0% subclinical hypothyroidism and 2.2% hyperthyroidism. Thyroid disorders are more common in female’s 16.5:1 fold. Compared with the control group, hypothyroid and subclinical hypothyroid DM patients have significant increase in TSH while significant decreases were observed in FT3 and FT4. TSH was significantly lower while FT3 and FT4 were significantly higher in hyperthyroidism DM patients. Moreover 23.3% of hypothyroidism has positive Tg-Ab, 23.3% has AM-Ab and 100% of hyperthyroidism has positive TR-Ab. The data suggested that, the prevalence of thyroid diseases is common in type 2 DM Libyan patients. Autoantibodies are the main causes of thyroid dysfunction, therefore, could predict and increase risk of thyroid disease, especially in females.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 3, Issue 1)
DOI	10.11648/j.ijcems.20170301.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Type 2 Diabetes Mellitus, Thyroid Dysfunction, Autoantibodies, Libya

References

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[2]	Makandar Asmabi, Sonagra Amit D, Biradar Shivaleela M, Quadri Shireen Swaliha, Effect of Thyroid Dysfunction on Metabolic Response in Type 2 Diabetic Patients. Unique Journal of Medical and Dental Sciences, 2015; 03 (01): 65-69.
[3]	Ramesh V, Geetha R, Anitha D, Nrvk S, Thangarajan T. P. The Study of Thyroid Dysfunction among Type 2 Diabetic Patients, international Journal of Current Research and Academic Review, 2015; 3 (9): 14-18.
[4]	Kiran Nagaraju, Amin Pirouz, Tayebeh Sadeghi, Pegah Esmaeili. Prevalence of thyroid dysfunction and its management in diabetic patients attending out patients clinic of Kim Hospital. International research journal of pharmacy, 2013, 4 (9): 132-35.
[5]	Ray KK, Seshasai SR, Wijesuriya S, Sivakumaran R, Nethercott S, Preiss D, Erqou S, Sattar N. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a metaanalysis of randomised controlled trials. The Lancet-Journal - Elsevier, 2009; 373 (9677): 1765-1772.
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[7]	Singh G, GuptaV, Sharma AK, Gupta N. Evaluation of Thyroid Dysfunction Among type 2 diabetic Punjabi population. Advances Bioresearch journal 2011; 2 (2): 3-9.
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[14]	Athanasia P. B, Alexios S, Anthi K, Marina K, Petroula S, Stavros P, Prevalence of Thyroid Dysfunction Among Greek Type 2 Diabetic Patients Attending an Outpatient Clinic, Journal of Clinical Medical Research, 2010; 2 (2): 75-78.
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APA Style

Ashraf Ahmed Ahmed, Siddig Bushra Mohamed, Salih Abdelgadir Elmadi, Abdelkarim A. Abdorabo, Ismail Mohamed Ismail, et al. (2017). Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya. International Journal of Clinical and Experimental Medical Sciences, 3(1), 1-4. https://doi.org/10.11648/j.ijcems.20170301.11

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ACS Style

Ashraf Ahmed Ahmed; Siddig Bushra Mohamed; Salih Abdelgadir Elmadi; Abdelkarim A. Abdorabo; Ismail Mohamed Ismail, et al. Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya. Int. J. Clin. Exp. Med. Sci. 2017, 3(1), 1-4. doi: 10.11648/j.ijcems.20170301.11

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AMA Style

Ashraf Ahmed Ahmed, Siddig Bushra Mohamed, Salih Abdelgadir Elmadi, Abdelkarim A. Abdorabo, Ismail Mohamed Ismail, et al. Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya. Int J Clin Exp Med Sci. 2017;3(1):1-4. doi: 10.11648/j.ijcems.20170301.11

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@article{10.11648/j.ijcems.20170301.11,
  author = {Ashraf Ahmed Ahmed and Siddig Bushra Mohamed and Salih Abdelgadir Elmadi and Abdelkarim A. Abdorabo and Ismail Mohamed Ismail and Amar Mohamed Ismail},
  title = {Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {3},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijcems.20170301.11},
  url = {https://doi.org/10.11648/j.ijcems.20170301.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20170301.11},
  abstract = {Diabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice. The study aim to find out the prevalence of thyroid disorders in type 2 diabetes mellitus patients. In a cross-sectional study 369 diagnosed type 2 DM patients, of which 203 are males and 166 are females, age reneged from (18 to 73) were enrolled, from July 2016 to July 2016. Their demographic data were obtained by through a questionnaire. Serum FT3, FT4, TSH and thyroid Antibodies (Tg-Ab, AM-Ab and TR-Ab) were measured using TOSOH, ELISA and enzymatic methods respectively. Out the 369 type 2 DM patients, of whom 9.5% are thyroid disorders, 2.3% have hypothyroidism, 5.0% subclinical hypothyroidism and 2.2% hyperthyroidism. Thyroid disorders are more common in female’s 16.5:1 fold. Compared with the control group, hypothyroid and subclinical hypothyroid DM patients have significant increase in TSH while significant decreases were observed in FT3 and FT4. TSH was significantly lower while FT3 and FT4 were significantly higher in hyperthyroidism DM patients. Moreover 23.3% of hypothyroidism has positive Tg-Ab, 23.3% has AM-Ab and 100% of hyperthyroidism has positive TR-Ab. The data suggested that, the prevalence of thyroid diseases is common in type 2 DM Libyan patients. Autoantibodies are the main causes of thyroid dysfunction, therefore, could predict and increase risk of thyroid disease, especially in females.},
 year = {2017}
}

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TY - JOUR
T1 - Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya
AU - Ashraf Ahmed Ahmed
AU - Siddig Bushra Mohamed
AU - Salih Abdelgadir Elmadi
AU - Abdelkarim A. Abdorabo
AU - Ismail Mohamed Ismail
AU - Amar Mohamed Ismail
Y1 - 2017/04/18
PY - 2017
N1 - https://doi.org/10.11648/j.ijcems.20170301.11
DO - 10.11648/j.ijcems.20170301.11
T2 - International Journal of Clinical and Experimental Medical Sciences
JF - International Journal of Clinical and Experimental Medical Sciences
JO - International Journal of Clinical and Experimental Medical Sciences
SP - 1
EP - 4
PB - Science Publishing Group
SN - 2469-8032
UR - https://doi.org/10.11648/j.ijcems.20170301.11
AB - Diabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice. The study aim to find out the prevalence of thyroid disorders in type 2 diabetes mellitus patients. In a cross-sectional study 369 diagnosed type 2 DM patients, of which 203 are males and 166 are females, age reneged from (18 to 73) were enrolled, from July 2016 to July 2016. Their demographic data were obtained by through a questionnaire. Serum FT3, FT4, TSH and thyroid Antibodies (Tg-Ab, AM-Ab and TR-Ab) were measured using TOSOH, ELISA and enzymatic methods respectively. Out the 369 type 2 DM patients, of whom 9.5% are thyroid disorders, 2.3% have hypothyroidism, 5.0% subclinical hypothyroidism and 2.2% hyperthyroidism. Thyroid disorders are more common in female’s 16.5:1 fold. Compared with the control group, hypothyroid and subclinical hypothyroid DM patients have significant increase in TSH while significant decreases were observed in FT3 and FT4. TSH was significantly lower while FT3 and FT4 were significantly higher in hyperthyroidism DM patients. Moreover 23.3% of hypothyroidism has positive Tg-Ab, 23.3% has AM-Ab and 100% of hyperthyroidism has positive TR-Ab. The data suggested that, the prevalence of thyroid diseases is common in type 2 DM Libyan patients. Autoantibodies are the main causes of thyroid dysfunction, therefore, could predict and increase risk of thyroid disease, especially in females.
VL - 3
IS - 1
ER -

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Author Information

Ashraf Ahmed Ahmed

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Al-Neelain, Khartoum, Sudan
Siddig Bushra Mohamed

Department of Medical Laboratory Sciences, Faculty of Medical Technology, Sabratha University, Surman, Libya
Salih Abdelgadir Elmadi

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, The National Ribat University, Khartoum, Sudan
Abdelkarim A. Abdorabo

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Al-Neelain, Khartoum, Sudan
Ismail Mohamed Ismail

Department of Biochemistry and Molecular Biology, Faculty of Sciences and Technology, University of Al-Neelain, Khartoum, Sudan
Amar Mohamed Ismail

Department of Biochemistry and Molecular Biology, Faculty of Sciences and Technology, University of Al-Neelain, Khartoum, Sudan

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APA Style

Ashraf Ahmed Ahmed, Siddig Bushra Mohamed, Salih Abdelgadir Elmadi, Abdelkarim A. Abdorabo, Ismail Mohamed Ismail, et al. (2017). Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya. International Journal of Clinical and Experimental Medical Sciences, 3(1), 1-4. https://doi.org/10.11648/j.ijcems.20170301.11

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ACS Style

Ashraf Ahmed Ahmed; Siddig Bushra Mohamed; Salih Abdelgadir Elmadi; Abdelkarim A. Abdorabo; Ismail Mohamed Ismail, et al. Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya. Int. J. Clin. Exp. Med. Sci. 2017, 3(1), 1-4. doi: 10.11648/j.ijcems.20170301.11

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AMA Style

Ashraf Ahmed Ahmed, Siddig Bushra Mohamed, Salih Abdelgadir Elmadi, Abdelkarim A. Abdorabo, Ismail Mohamed Ismail, et al. Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya. Int J Clin Exp Med Sci. 2017;3(1):1-4. doi: 10.11648/j.ijcems.20170301.11

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@article{10.11648/j.ijcems.20170301.11,
  author = {Ashraf Ahmed Ahmed and Siddig Bushra Mohamed and Salih Abdelgadir Elmadi and Abdelkarim A. Abdorabo and Ismail Mohamed Ismail and Amar Mohamed Ismail},
  title = {Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {3},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijcems.20170301.11},
  url = {https://doi.org/10.11648/j.ijcems.20170301.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20170301.11},
  abstract = {Diabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice. The study aim to find out the prevalence of thyroid disorders in type 2 diabetes mellitus patients. In a cross-sectional study 369 diagnosed type 2 DM patients, of which 203 are males and 166 are females, age reneged from (18 to 73) were enrolled, from July 2016 to July 2016. Their demographic data were obtained by through a questionnaire. Serum FT3, FT4, TSH and thyroid Antibodies (Tg-Ab, AM-Ab and TR-Ab) were measured using TOSOH, ELISA and enzymatic methods respectively. Out the 369 type 2 DM patients, of whom 9.5% are thyroid disorders, 2.3% have hypothyroidism, 5.0% subclinical hypothyroidism and 2.2% hyperthyroidism. Thyroid disorders are more common in female’s 16.5:1 fold. Compared with the control group, hypothyroid and subclinical hypothyroid DM patients have significant increase in TSH while significant decreases were observed in FT3 and FT4. TSH was significantly lower while FT3 and FT4 were significantly higher in hyperthyroidism DM patients. Moreover 23.3% of hypothyroidism has positive Tg-Ab, 23.3% has AM-Ab and 100% of hyperthyroidism has positive TR-Ab. The data suggested that, the prevalence of thyroid diseases is common in type 2 DM Libyan patients. Autoantibodies are the main causes of thyroid dysfunction, therefore, could predict and increase risk of thyroid disease, especially in females.},
 year = {2017}
}

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