Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model

Masanori Watanabe; Satoshi Kojima; Keiji Asada; Itaru Hibino; Masahiro Hoso

doi:doi:10.11648/j.ijcems.20180402.11

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Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model

Masanori Watanabe, Satoshi Kojima, Keiji Asada, Itaru Hibino, Masahiro Hoso

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 4, Issue 2)

Received: 28 March 2018 Accepted: 17 April 2018 Published: 10 May 2018

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Abstract

This study aimed to investigate and clarify the effect of aging on the progression of cartilage damage using a rat osteoarthritis model. In total, 12 rats, including three rats per age group, were assigned to the experimental group, and two rats (one 3 and 18 months old each) were assigned to the control group. In the experimental group, joint instability was induced using the destabilization of the medial meniscus model. After completion of the 4-week experimental period, the bilateral knee joints were harvested and the histological changes in the articular structures of the joints were observed using a light microscope. Medial dislocation of the medial meniscus, low staining of the cartilaginous substrate on the tibial side localized around the medial meniscus tip, and irregularities and fibrillation of the superficial layer of the cartilage on the tibial side were observed in all experimental age groups. No significant age-related differences were observed in the degree of observed findings and the score of cartilage degeneration. The results indicate that aging does not affect the early stages of progression of cartilage damage.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 4, Issue 2)
DOI	10.11648/j.ijcems.20180402.11
Page(s)	21-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Osteoarthritis, Aging, Histopathology

References

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APA Style

Masanori Watanabe, Satoshi Kojima, Keiji Asada, Itaru Hibino, Masahiro Hoso. (2018). Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model. International Journal of Clinical and Experimental Medical Sciences, 4(2), 21-25. https://doi.org/10.11648/j.ijcems.20180402.11

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ACS Style

Masanori Watanabe; Satoshi Kojima; Keiji Asada; Itaru Hibino; Masahiro Hoso. Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model. Int. J. Clin. Exp. Med. Sci. 2018, 4(2), 21-25. doi: 10.11648/j.ijcems.20180402.11

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AMA Style

Masanori Watanabe, Satoshi Kojima, Keiji Asada, Itaru Hibino, Masahiro Hoso. Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model. Int J Clin Exp Med Sci. 2018;4(2):21-25. doi: 10.11648/j.ijcems.20180402.11

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@article{10.11648/j.ijcems.20180402.11,
  author = {Masanori Watanabe and Satoshi Kojima and Keiji Asada and Itaru Hibino and Masahiro Hoso},
  title = {Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {4},
  number = {2},
  pages = {21-25},
  doi = {10.11648/j.ijcems.20180402.11},
  url = {https://doi.org/10.11648/j.ijcems.20180402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20180402.11},
  abstract = {This study aimed to investigate and clarify the effect of aging on the progression of cartilage damage using a rat osteoarthritis model. In total, 12 rats, including three rats per age group, were assigned to the experimental group, and two rats (one 3 and 18 months old each) were assigned to the control group. In the experimental group, joint instability was induced using the destabilization of the medial meniscus model. After completion of the 4-week experimental period, the bilateral knee joints were harvested and the histological changes in the articular structures of the joints were observed using a light microscope. Medial dislocation of the medial meniscus, low staining of the cartilaginous substrate on the tibial side localized around the medial meniscus tip, and irregularities and fibrillation of the superficial layer of the cartilage on the tibial side were observed in all experimental age groups. No significant age-related differences were observed in the degree of observed findings and the score of cartilage degeneration. The results indicate that aging does not affect the early stages of progression of cartilage damage.},
 year = {2018}
}

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TY  - JOUR
T1  - Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model
AU  - Masanori Watanabe
AU  - Satoshi Kojima
AU  - Keiji Asada
AU  - Itaru Hibino
AU  - Masahiro Hoso
Y1  - 2018/05/10
PY  - 2018
N1  - https://doi.org/10.11648/j.ijcems.20180402.11
DO  - 10.11648/j.ijcems.20180402.11
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 21
EP  - 25
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20180402.11
AB  - This study aimed to investigate and clarify the effect of aging on the progression of cartilage damage using a rat osteoarthritis model. In total, 12 rats, including three rats per age group, were assigned to the experimental group, and two rats (one 3 and 18 months old each) were assigned to the control group. In the experimental group, joint instability was induced using the destabilization of the medial meniscus model. After completion of the 4-week experimental period, the bilateral knee joints were harvested and the histological changes in the articular structures of the joints were observed using a light microscope. Medial dislocation of the medial meniscus, low staining of the cartilaginous substrate on the tibial side localized around the medial meniscus tip, and irregularities and fibrillation of the superficial layer of the cartilage on the tibial side were observed in all experimental age groups. No significant age-related differences were observed in the degree of observed findings and the score of cartilage degeneration. The results indicate that aging does not affect the early stages of progression of cartilage damage.
VL  - 4
IS  - 2
ER  -

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Author Information

Masanori Watanabe

Department of Physical Therapy, Faculty of Rehabilitation Science, Nagoya Gakuin University, Seto, Japan
Satoshi Kojima

Course of Rehabilitation, Graduate School of Rehabilitation, Kinjo University, Hakusan, Japan
Keiji Asada

Department of Physiotherapy, Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Japan
Itaru Hibino

Department of Physical Therapy, Faculty of Rehabilitation Science, Nagoya Gakuin University, Seto, Japan
Masahiro Hoso

Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

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Plain Text BibTeX RIS

APA Style

Masanori Watanabe, Satoshi Kojima, Keiji Asada, Itaru Hibino, Masahiro Hoso. (2018). Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model. International Journal of Clinical and Experimental Medical Sciences, 4(2), 21-25. https://doi.org/10.11648/j.ijcems.20180402.11

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ACS Style

Masanori Watanabe; Satoshi Kojima; Keiji Asada; Itaru Hibino; Masahiro Hoso. Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model. Int. J. Clin. Exp. Med. Sci. 2018, 4(2), 21-25. doi: 10.11648/j.ijcems.20180402.11

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AMA Style

Masanori Watanabe, Satoshi Kojima, Keiji Asada, Itaru Hibino, Masahiro Hoso. Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model. Int J Clin Exp Med Sci. 2018;4(2):21-25. doi: 10.11648/j.ijcems.20180402.11

Copy | Download

@article{10.11648/j.ijcems.20180402.11,
  author = {Masanori Watanabe and Satoshi Kojima and Keiji Asada and Itaru Hibino and Masahiro Hoso},
  title = {Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {4},
  number = {2},
  pages = {21-25},
  doi = {10.11648/j.ijcems.20180402.11},
  url = {https://doi.org/10.11648/j.ijcems.20180402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20180402.11},
  abstract = {This study aimed to investigate and clarify the effect of aging on the progression of cartilage damage using a rat osteoarthritis model. In total, 12 rats, including three rats per age group, were assigned to the experimental group, and two rats (one 3 and 18 months old each) were assigned to the control group. In the experimental group, joint instability was induced using the destabilization of the medial meniscus model. After completion of the 4-week experimental period, the bilateral knee joints were harvested and the histological changes in the articular structures of the joints were observed using a light microscope. Medial dislocation of the medial meniscus, low staining of the cartilaginous substrate on the tibial side localized around the medial meniscus tip, and irregularities and fibrillation of the superficial layer of the cartilage on the tibial side were observed in all experimental age groups. No significant age-related differences were observed in the degree of observed findings and the score of cartilage degeneration. The results indicate that aging does not affect the early stages of progression of cartilage damage.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Effect of Aging on the Progression of Articular Cartilage Damage in a Rat Osteoarthritis Model
AU  - Masanori Watanabe
AU  - Satoshi Kojima
AU  - Keiji Asada
AU  - Itaru Hibino
AU  - Masahiro Hoso
Y1  - 2018/05/10
PY  - 2018
N1  - https://doi.org/10.11648/j.ijcems.20180402.11
DO  - 10.11648/j.ijcems.20180402.11
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 21
EP  - 25
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20180402.11
AB  - This study aimed to investigate and clarify the effect of aging on the progression of cartilage damage using a rat osteoarthritis model. In total, 12 rats, including three rats per age group, were assigned to the experimental group, and two rats (one 3 and 18 months old each) were assigned to the control group. In the experimental group, joint instability was induced using the destabilization of the medial meniscus model. After completion of the 4-week experimental period, the bilateral knee joints were harvested and the histological changes in the articular structures of the joints were observed using a light microscope. Medial dislocation of the medial meniscus, low staining of the cartilaginous substrate on the tibial side localized around the medial meniscus tip, and irregularities and fibrillation of the superficial layer of the cartilage on the tibial side were observed in all experimental age groups. No significant age-related differences were observed in the degree of observed findings and the score of cartilage degeneration. The results indicate that aging does not affect the early stages of progression of cartilage damage.
VL  - 4
IS  - 2
ER  -

Copy | Download