Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects many extrahepatic-organ systems. In this respect, several studies have suggested the possible association between NAFLD and the risk of incident chronic kidney disease (CKD). However, the extent of this association remains unclear. Thus the present meta-analysis was conducted to better characterize this association. In the meta-analysis, a comprehensive search of the databases of MEDLINE, EMBASE, Web of Science and Cochran Library was carried out from inception through September 2017. All large observational studies that investigated the association between NAFLD and the risk of incident CKD were included. The incident CKD was defined as occurrence of estimated glomerular filtration rate (eGFR) < 60ml/min/1.73m2 and/or overt proteinuria. The pooled hazard ratio (HR) with 95% confidence intervals (CIs) was calculated using the random-effects model. Data were extracted from 5 large observational studies involving 57,341 adult individuals (41.3% with NAFLD) with 1,886 cases of incident CKD. NAFLD is significantly associated with increased risk of incident CKD (HR 1.40, 95%CI 1.22-1.61). The statistical heterogeneity of included studies was low, with an I2=25.4%. In conclusion, the present meta-analysis confirms the association between NAFLD and the risk of incident CKD.
| Published in | International Journal of Clinical and Experimental Medical Sciences (Volume 4, Issue 2) |
| DOI | 10.11648/j.ijcems.20180402.12 |
| Page(s) | 26-31 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Nonalcoholic Fatty Liver, Chronic Kidney Disease, Meta-Analysis
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APA Style
Yichao Zheng, Yifen Wu, Yadong Lai, Hanxu Zhuang, Guian Zheng. (2018). Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis. International Journal of Clinical and Experimental Medical Sciences, 4(2), 26-31. https://doi.org/10.11648/j.ijcems.20180402.12
ACS Style
Yichao Zheng; Yifen Wu; Yadong Lai; Hanxu Zhuang; Guian Zheng. Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis. Int. J. Clin. Exp. Med. Sci. 2018, 4(2), 26-31. doi: 10.11648/j.ijcems.20180402.12
AMA Style
Yichao Zheng, Yifen Wu, Yadong Lai, Hanxu Zhuang, Guian Zheng. Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis. Int J Clin Exp Med Sci. 2018;4(2):26-31. doi: 10.11648/j.ijcems.20180402.12
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Download@article{10.11648/j.ijcems.20180402.12,
author = {Yichao Zheng and Yifen Wu and Yadong Lai and Hanxu Zhuang and Guian Zheng},
title = {Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis},
journal = {International Journal of Clinical and Experimental Medical Sciences},
volume = {4},
number = {2},
pages = {26-31},
doi = {10.11648/j.ijcems.20180402.12},
url = {https://doi.org/10.11648/j.ijcems.20180402.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20180402.12},
abstract = {Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects many extrahepatic-organ systems. In this respect, several studies have suggested the possible association between NAFLD and the risk of incident chronic kidney disease (CKD). However, the extent of this association remains unclear. Thus the present meta-analysis was conducted to better characterize this association. In the meta-analysis, a comprehensive search of the databases of MEDLINE, EMBASE, Web of Science and Cochran Library was carried out from inception through September 2017. All large observational studies that investigated the association between NAFLD and the risk of incident CKD were included. The incident CKD was defined as occurrence of estimated glomerular filtration rate (eGFR) 2 and/or overt proteinuria. The pooled hazard ratio (HR) with 95% confidence intervals (CIs) was calculated using the random-effects model. Data were extracted from 5 large observational studies involving 57,341 adult individuals (41.3% with NAFLD) with 1,886 cases of incident CKD. NAFLD is significantly associated with increased risk of incident CKD (HR 1.40, 95%CI 1.22-1.61). The statistical heterogeneity of included studies was low, with an I2=25.4%. In conclusion, the present meta-analysis confirms the association between NAFLD and the risk of incident CKD.},
year = {2018}
}
TY - JOUR T1 - Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis AU - Yichao Zheng AU - Yifen Wu AU - Yadong Lai AU - Hanxu Zhuang AU - Guian Zheng Y1 - 2018/05/19 PY - 2018 N1 - https://doi.org/10.11648/j.ijcems.20180402.12 DO - 10.11648/j.ijcems.20180402.12 T2 - International Journal of Clinical and Experimental Medical Sciences JF - International Journal of Clinical and Experimental Medical Sciences JO - International Journal of Clinical and Experimental Medical Sciences SP - 26 EP - 31 PB - Science Publishing Group SN - 2469-8032 UR - https://doi.org/10.11648/j.ijcems.20180402.12 AB - Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects many extrahepatic-organ systems. In this respect, several studies have suggested the possible association between NAFLD and the risk of incident chronic kidney disease (CKD). However, the extent of this association remains unclear. Thus the present meta-analysis was conducted to better characterize this association. In the meta-analysis, a comprehensive search of the databases of MEDLINE, EMBASE, Web of Science and Cochran Library was carried out from inception through September 2017. All large observational studies that investigated the association between NAFLD and the risk of incident CKD were included. The incident CKD was defined as occurrence of estimated glomerular filtration rate (eGFR) 2 and/or overt proteinuria. The pooled hazard ratio (HR) with 95% confidence intervals (CIs) was calculated using the random-effects model. Data were extracted from 5 large observational studies involving 57,341 adult individuals (41.3% with NAFLD) with 1,886 cases of incident CKD. NAFLD is significantly associated with increased risk of incident CKD (HR 1.40, 95%CI 1.22-1.61). The statistical heterogeneity of included studies was low, with an I2=25.4%. In conclusion, the present meta-analysis confirms the association between NAFLD and the risk of incident CKD. VL - 4 IS - 2 ER -
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