Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease

Hui Huang; Liyuan Xie; Min Chen; Ming Guo; Xingen Zhu; Suyue Zheng; Mingwei Lu

doi:doi:10.11648/j.ijcems.20190504.12

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Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease

Hui Huang, Liyuan Xie, Min Chen, Ming Guo, Xingen Zhu, Suyue Zheng, Mingwei Lu

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 4)

Received: 14 August 2019 Accepted: 10 September 2019 Published: 26 September 2019

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Abstract

Objectives: To study the therapeutic effect and complications of deep brain stimulation (DBS) to Parkinson’s disease (PD). Patients and Methods: A retrospective analysis of DBS performed on 44 patients with Parkinson’s disease who had complications in the post-operation. Results: 1). A stimulation effect was observed in all PD patients during the operation, with the most obvious effect being relief of muscular tension, followed by improvement in tremor and bradykinesia. 2). The implantable pulse generator was activated from 3 days to 1 month after the implantation of the stimulation electrode, and then had an obvious effect. 3). Clinical follow-up was performed from 3 months to 2.5 years post-implantation. The symptoms assessed using the UPDRS score were significantly improved. 4). Two cases of cerebral hemorrhage and vesicular effusion were related to surgical methods. There were several cases of pneumonia in the postoperative fever and two cases of urinary system infection. One case of traverse fracture also occurred. Postoperative electrode exposure and local infection occurred in 1 case. There were 3 cases of lethargy, 2 cases of hallucinations. In the postoperative period, intelligence decreased further in 1 case. One patient had no obvious improvement in rigidity. 5). One case had difficulties in eye opening within 1 month. One case of PD had poor rigidity control. There was also decrease memory after stimulation in 2 cases. Conclusion: Proper selection of patients, appropriate DBS surgical methods and reasonable adjustment of stimulation parameters can effectively prevent and treat related complications.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 4)
DOI	10.11648/j.ijcems.20190504.12
Page(s)	58-61
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

DBS, PD, Complications, Surgery

References

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APA Style

Hui Huang, Liyuan Xie, Min Chen, Ming Guo, Xingen Zhu, et al. (2019). Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. International Journal of Clinical and Experimental Medical Sciences, 5(4), 58-61. https://doi.org/10.11648/j.ijcems.20190504.12

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ACS Style

Hui Huang; Liyuan Xie; Min Chen; Ming Guo; Xingen Zhu, et al. Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. Int. J. Clin. Exp. Med. Sci. 2019, 5(4), 58-61. doi: 10.11648/j.ijcems.20190504.12

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AMA Style

Hui Huang, Liyuan Xie, Min Chen, Ming Guo, Xingen Zhu, et al. Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. Int J Clin Exp Med Sci. 2019;5(4):58-61. doi: 10.11648/j.ijcems.20190504.12

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@article{10.11648/j.ijcems.20190504.12,
  author = {Hui Huang and Liyuan Xie and Min Chen and Ming Guo and Xingen Zhu and Suyue Zheng and Mingwei Lu},
  title = {Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {5},
  number = {4},
  pages = {58-61},
  doi = {10.11648/j.ijcems.20190504.12},
  url = {https://doi.org/10.11648/j.ijcems.20190504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190504.12},
  abstract = {Objectives: To study the therapeutic effect and complications of deep brain stimulation (DBS) to Parkinson’s disease (PD). Patients and Methods: A retrospective analysis of DBS performed on 44 patients with Parkinson’s disease who had complications in the post-operation. Results: 1). A stimulation effect was observed in all PD patients during the operation, with the most obvious effect being relief of muscular tension, followed by improvement in tremor and bradykinesia. 2). The implantable pulse generator was activated from 3 days to 1 month after the implantation of the stimulation electrode, and then had an obvious effect. 3). Clinical follow-up was performed from 3 months to 2.5 years post-implantation. The symptoms assessed using the UPDRS score were significantly improved. 4). Two cases of cerebral hemorrhage and vesicular effusion were related to surgical methods. There were several cases of pneumonia in the postoperative fever and two cases of urinary system infection. One case of traverse fracture also occurred. Postoperative electrode exposure and local infection occurred in 1 case. There were 3 cases of lethargy, 2 cases of hallucinations. In the postoperative period, intelligence decreased further in 1 case. One patient had no obvious improvement in rigidity. 5). One case had difficulties in eye opening within 1 month. One case of PD had poor rigidity control. There was also decrease memory after stimulation in 2 cases. Conclusion: Proper selection of patients, appropriate DBS surgical methods and reasonable adjustment of stimulation parameters can effectively prevent and treat related complications.},
 year = {2019}
}

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TY - JOUR
T1 - Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease
AU - Hui Huang
AU - Liyuan Xie
AU - Min Chen
AU - Ming Guo
AU - Xingen Zhu
AU - Suyue Zheng
AU - Mingwei Lu
Y1 - 2019/09/26
PY - 2019
N1 - https://doi.org/10.11648/j.ijcems.20190504.12
DO - 10.11648/j.ijcems.20190504.12
T2 - International Journal of Clinical and Experimental Medical Sciences
JF - International Journal of Clinical and Experimental Medical Sciences
JO - International Journal of Clinical and Experimental Medical Sciences
SP - 58
EP - 61
PB - Science Publishing Group
SN - 2469-8032
UR - https://doi.org/10.11648/j.ijcems.20190504.12
AB - Objectives: To study the therapeutic effect and complications of deep brain stimulation (DBS) to Parkinson’s disease (PD). Patients and Methods: A retrospective analysis of DBS performed on 44 patients with Parkinson’s disease who had complications in the post-operation. Results: 1). A stimulation effect was observed in all PD patients during the operation, with the most obvious effect being relief of muscular tension, followed by improvement in tremor and bradykinesia. 2). The implantable pulse generator was activated from 3 days to 1 month after the implantation of the stimulation electrode, and then had an obvious effect. 3). Clinical follow-up was performed from 3 months to 2.5 years post-implantation. The symptoms assessed using the UPDRS score were significantly improved. 4). Two cases of cerebral hemorrhage and vesicular effusion were related to surgical methods. There were several cases of pneumonia in the postoperative fever and two cases of urinary system infection. One case of traverse fracture also occurred. Postoperative electrode exposure and local infection occurred in 1 case. There were 3 cases of lethargy, 2 cases of hallucinations. In the postoperative period, intelligence decreased further in 1 case. One patient had no obvious improvement in rigidity. 5). One case had difficulties in eye opening within 1 month. One case of PD had poor rigidity control. There was also decrease memory after stimulation in 2 cases. Conclusion: Proper selection of patients, appropriate DBS surgical methods and reasonable adjustment of stimulation parameters can effectively prevent and treat related complications.
VL - 5
IS - 4
ER -

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Author Information

Hui Huang

Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Liyuan Xie

Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Min Chen

Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Ming Guo

Psychosomatic Medicine, Second Affiliation Hospital, Nanchang University, Nanchang, China
Xingen Zhu

Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Suyue Zheng

Department of Neurosurgery, First Affiliation Hospital, Nanchang University, Nanchang, China
Mingwei Lu

Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China

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APA Style

Hui Huang, Liyuan Xie, Min Chen, Ming Guo, Xingen Zhu, et al. (2019). Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. International Journal of Clinical and Experimental Medical Sciences, 5(4), 58-61. https://doi.org/10.11648/j.ijcems.20190504.12

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ACS Style

Hui Huang; Liyuan Xie; Min Chen; Ming Guo; Xingen Zhu, et al. Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. Int. J. Clin. Exp. Med. Sci. 2019, 5(4), 58-61. doi: 10.11648/j.ijcems.20190504.12

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AMA Style

Hui Huang, Liyuan Xie, Min Chen, Ming Guo, Xingen Zhu, et al. Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. Int J Clin Exp Med Sci. 2019;5(4):58-61. doi: 10.11648/j.ijcems.20190504.12

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@article{10.11648/j.ijcems.20190504.12,
  author = {Hui Huang and Liyuan Xie and Min Chen and Ming Guo and Xingen Zhu and Suyue Zheng and Mingwei Lu},
  title = {Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {5},
  number = {4},
  pages = {58-61},
  doi = {10.11648/j.ijcems.20190504.12},
  url = {https://doi.org/10.11648/j.ijcems.20190504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190504.12},
  abstract = {Objectives: To study the therapeutic effect and complications of deep brain stimulation (DBS) to Parkinson’s disease (PD). Patients and Methods: A retrospective analysis of DBS performed on 44 patients with Parkinson’s disease who had complications in the post-operation. Results: 1). A stimulation effect was observed in all PD patients during the operation, with the most obvious effect being relief of muscular tension, followed by improvement in tremor and bradykinesia. 2). The implantable pulse generator was activated from 3 days to 1 month after the implantation of the stimulation electrode, and then had an obvious effect. 3). Clinical follow-up was performed from 3 months to 2.5 years post-implantation. The symptoms assessed using the UPDRS score were significantly improved. 4). Two cases of cerebral hemorrhage and vesicular effusion were related to surgical methods. There were several cases of pneumonia in the postoperative fever and two cases of urinary system infection. One case of traverse fracture also occurred. Postoperative electrode exposure and local infection occurred in 1 case. There were 3 cases of lethargy, 2 cases of hallucinations. In the postoperative period, intelligence decreased further in 1 case. One patient had no obvious improvement in rigidity. 5). One case had difficulties in eye opening within 1 month. One case of PD had poor rigidity control. There was also decrease memory after stimulation in 2 cases. Conclusion: Proper selection of patients, appropriate DBS surgical methods and reasonable adjustment of stimulation parameters can effectively prevent and treat related complications.},
 year = {2019}
}

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