Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Arasch Bareksei; Gerd Hafner; Sebastian Pfeiffer; Kathrin Schlatterer

doi:doi:10.11648/j.ijcems.20190505.11

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Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 5)

Received: 6 September 2019 Accepted: 27 September 2019 Published: 10 October 2019

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Abstract

Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3- fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVF-success by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The “historical” control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further age-matched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 5)
DOI	10.11648/j.ijcems.20190505.11
Page(s)	62-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Omega-3-Fatty Acid Supplementation, In Vitro Fertilization, Miscarriage Rates

References

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APA Style

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. (2019). Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. International Journal of Clinical and Experimental Medical Sciences, 5(5), 62-66. https://doi.org/10.11648/j.ijcems.20190505.11

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ACS Style

Arasch Bareksei; Gerd Hafner; Sebastian Pfeiffer; Kathrin Schlatterer. Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. Int. J. Clin. Exp. Med. Sci. 2019, 5(5), 62-66. doi: 10.11648/j.ijcems.20190505.11

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AMA Style

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. Int J Clin Exp Med Sci. 2019;5(5):62-66. doi: 10.11648/j.ijcems.20190505.11

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@article{10.11648/j.ijcems.20190505.11,
  author = {Arasch Bareksei and Gerd Hafner and Sebastian Pfeiffer and Kathrin Schlatterer},
  title = {Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {5},
  number = {5},
  pages = {62-66},
  doi = {10.11648/j.ijcems.20190505.11},
  url = {https://doi.org/10.11648/j.ijcems.20190505.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190505.11},
  abstract = {Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3- fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVF-success by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The “historical” control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further age-matched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.},
 year = {2019}
}

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TY  - JOUR
T1  - Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre
AU  - Arasch Bareksei
AU  - Gerd Hafner
AU  - Sebastian Pfeiffer
AU  - Kathrin Schlatterer
Y1  - 2019/10/10
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcems.20190505.11
DO  - 10.11648/j.ijcems.20190505.11
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 62
EP  - 66
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20190505.11
AB  - Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3- fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVF-success by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The “historical” control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further age-matched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.
VL  - 5
IS  - 5
ER  -

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Author Information

Arasch Bareksei

Dental Concept, Praxis für Zahn, Mund-Und Kieferheilkunde, Voerde, Germany
Gerd Hafner

Institut für Laboratoriumsmedizin, Mikrobiologie Und Hygiene, Evangelisches Klinikum Bethel, Bielefeld, Germany
Sebastian Pfeiffer

Labor Todorov, Düsseldorf, Germany
Kathrin Schlatterer

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Dessau, Germany

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APA Style

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. (2019). Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. International Journal of Clinical and Experimental Medical Sciences, 5(5), 62-66. https://doi.org/10.11648/j.ijcems.20190505.11

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ACS Style

Arasch Bareksei; Gerd Hafner; Sebastian Pfeiffer; Kathrin Schlatterer. Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. Int. J. Clin. Exp. Med. Sci. 2019, 5(5), 62-66. doi: 10.11648/j.ijcems.20190505.11

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AMA Style

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. Int J Clin Exp Med Sci. 2019;5(5):62-66. doi: 10.11648/j.ijcems.20190505.11

Copy | Download

@article{10.11648/j.ijcems.20190505.11,
  author = {Arasch Bareksei and Gerd Hafner and Sebastian Pfeiffer and Kathrin Schlatterer},
  title = {Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {5},
  number = {5},
  pages = {62-66},
  doi = {10.11648/j.ijcems.20190505.11},
  url = {https://doi.org/10.11648/j.ijcems.20190505.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190505.11},
  abstract = {Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3- fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVF-success by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The “historical” control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further age-matched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre
AU  - Arasch Bareksei
AU  - Gerd Hafner
AU  - Sebastian Pfeiffer
AU  - Kathrin Schlatterer
Y1  - 2019/10/10
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcems.20190505.11
DO  - 10.11648/j.ijcems.20190505.11
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 62
EP  - 66
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20190505.11
AB  - Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3- fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVF-success by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The “historical” control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further age-matched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.
VL  - 5
IS  - 5
ER  -

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