Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus

Hayder M. Al-kuraishy; Ali I. Al-Gareeb; Salah A. Al-Windy

doi:doi:10.11648/j.ijde.20160101.12

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Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus

Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Salah A. Al-Windy

Published in International Journal of Diabetes and Endocrinology (Volume 1, Issue 1)

Received: 4 November 2016 Accepted: 2 December 2016 Published: 27 December 2016

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Abstract

Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.

Published in	International Journal of Diabetes and Endocrinology (Volume 1, Issue 1)
DOI	10.11648/j.ijde.20160101.12
Page(s)	8-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Testosterone, Metformin, Glyburide, Type 2DM

References

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APA Style

Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Salah A. Al-Windy. (2016). Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. International Journal of Diabetes and Endocrinology, 1(1), 8-12. https://doi.org/10.11648/j.ijde.20160101.12

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ACS Style

Hayder M. Al-kuraishy; Ali I. Al-Gareeb; Salah A. Al-Windy. Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. Int. J. Diabetes Endocrinol. 2016, 1(1), 8-12. doi: 10.11648/j.ijde.20160101.12

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AMA Style

Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Salah A. Al-Windy. Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. Int J Diabetes Endocrinol. 2016;1(1):8-12. doi: 10.11648/j.ijde.20160101.12

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@article{10.11648/j.ijde.20160101.12,
  author = {Hayder M. Al-kuraishy and Ali I. Al-Gareeb and Salah A. Al-Windy},
  title = {Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {1},
  number = {1},
  pages = {8-12},
  doi = {10.11648/j.ijde.20160101.12},
  url = {https://doi.org/10.11648/j.ijde.20160101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20160101.12},
  abstract = {Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.},
 year = {2016}
}

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TY  - JOUR
T1  - Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus
AU  - Hayder M. Al-kuraishy
AU  - Ali I. Al-Gareeb
AU  - Salah A. Al-Windy
Y1  - 2016/12/27
PY  - 2016
N1  - https://doi.org/10.11648/j.ijde.20160101.12
DO  - 10.11648/j.ijde.20160101.12
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 8
EP  - 12
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20160101.12
AB  - Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.
VL  - 1
IS  - 1
ER  -

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Author Information

Hayder M. Al-kuraishy

Department of Pharmacology, Toxicology and Medicine College of Medicine, Almustansiriya University, Baghdad, Iraq
Ali I. Al-Gareeb

Department of Pharmacology, Toxicology and Medicine College of Medicine, Almustansiriya University, Baghdad, Iraq
Salah A. Al-Windy

Department of Biology and Biochemistry, College of Sciences, Baghdad University, Baghdad, Iraq

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Plain Text BibTeX RIS

APA Style

Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Salah A. Al-Windy. (2016). Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. International Journal of Diabetes and Endocrinology, 1(1), 8-12. https://doi.org/10.11648/j.ijde.20160101.12

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ACS Style

Hayder M. Al-kuraishy; Ali I. Al-Gareeb; Salah A. Al-Windy. Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. Int. J. Diabetes Endocrinol. 2016, 1(1), 8-12. doi: 10.11648/j.ijde.20160101.12

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AMA Style

Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Salah A. Al-Windy. Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. Int J Diabetes Endocrinol. 2016;1(1):8-12. doi: 10.11648/j.ijde.20160101.12

Copy | Download

@article{10.11648/j.ijde.20160101.12,
  author = {Hayder M. Al-kuraishy and Ali I. Al-Gareeb and Salah A. Al-Windy},
  title = {Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {1},
  number = {1},
  pages = {8-12},
  doi = {10.11648/j.ijde.20160101.12},
  url = {https://doi.org/10.11648/j.ijde.20160101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20160101.12},
  abstract = {Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.},
 year = {2016}
}

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TY  - JOUR
T1  - Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus
AU  - Hayder M. Al-kuraishy
AU  - Ali I. Al-Gareeb
AU  - Salah A. Al-Windy
Y1  - 2016/12/27
PY  - 2016
N1  - https://doi.org/10.11648/j.ijde.20160101.12
DO  - 10.11648/j.ijde.20160101.12
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 8
EP  - 12
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20160101.12
AB  - Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.
VL  - 1
IS  - 1
ER  -

Copy | Download