Thyroid dysfunction occurs in 5-18% of pregnant women and is associated with a higher risk of various gynecological and obstetric complications and these differences are due to the specific characteristic of the study population. The aim of the present study is to analyze the population of pregnant women in Bulgaria regarding the main parameters that are relevant to their thyroid status - age, sequence of pregnancy, reproductive problems, family history of thyroid disease, body mass index. Material: We studied 547 pregnant women, mean age 30±5 years. The study was conducted as a cross-sectional multicenter population-based in 10 regions of Bulgaria or a total of 84 settlements. Methods: An individual Questionnaire was completed, determined in a central laboratory with ECLIA method TSH, FT4, TPOAb and ultrasound examination of the cervical region was conducted. Statistical processing of the material was performed using the standard SPSS 13.0 for Windows. Results: TSH levels are negatively correlated with age, P<0.07. The thyroid volume for the group of women with first pregnancy (n-245, 44.8%) is 8.67±2.23 mL, median 8.35 mL, and the thyroid volume in the remaining 302 (55.2%) women with another pregnancy is 9.15±2.85 mL, median 8.96 mL (P<0.01). Reproductive problems were reported in 119 (21.8%) pregnant women, but the correlation with TSH levels was weak, P<0.009. In 25% of women with family history of thyroid pathology there are abnormalities in thyroid function (in 96.4% hypothyroidism and in 3.6% hyperthyroidism). While in euthyroid pregnant women previous obesity was present in 8.6% (30/350), in hypothyroid pregnant women it was found in 12.7% (14/110), P<0.035. In other words, BMI before pregnancy is a significant predictor of hypothyroidism, proven during pregnancy. Conclusion: The preliminary in-depth study and presentation of the characteristics of the studied Bulgarian population of pregnant women is the basis for a proper assessment of the condition of the thyroid gland.
| Published in | International Journal of Diabetes and Endocrinology (Volume 5, Issue 4) |
| DOI | 10.11648/j.ijde.20200504.17 |
| Page(s) | 89-95 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Thyroid Status, Age, Sequence of Pregnancy, Reproductive Problems, Family History, Body Mass Index
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APA Style
Anna-Maria Borissova, Boyana Trifonova, Lilia Dakovska, Eugenia Michaylova, Mircho Vukov. (2020). Factors Determining Thyroid Status in Pregnant Women in Bulgaria. International Journal of Diabetes and Endocrinology, 5(4), 89-95. https://doi.org/10.11648/j.ijde.20200504.17
ACS Style
Anna-Maria Borissova; Boyana Trifonova; Lilia Dakovska; Eugenia Michaylova; Mircho Vukov. Factors Determining Thyroid Status in Pregnant Women in Bulgaria. Int. J. Diabetes Endocrinol. 2020, 5(4), 89-95. doi: 10.11648/j.ijde.20200504.17
AMA Style
Anna-Maria Borissova, Boyana Trifonova, Lilia Dakovska, Eugenia Michaylova, Mircho Vukov. Factors Determining Thyroid Status in Pregnant Women in Bulgaria. Int J Diabetes Endocrinol. 2020;5(4):89-95. doi: 10.11648/j.ijde.20200504.17
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Download@article{10.11648/j.ijde.20200504.17,
author = {Anna-Maria Borissova and Boyana Trifonova and Lilia Dakovska and Eugenia Michaylova and Mircho Vukov},
title = {Factors Determining Thyroid Status in Pregnant Women in Bulgaria},
journal = {International Journal of Diabetes and Endocrinology},
volume = {5},
number = {4},
pages = {89-95},
doi = {10.11648/j.ijde.20200504.17},
url = {https://doi.org/10.11648/j.ijde.20200504.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20200504.17},
abstract = {Thyroid dysfunction occurs in 5-18% of pregnant women and is associated with a higher risk of various gynecological and obstetric complications and these differences are due to the specific characteristic of the study population. The aim of the present study is to analyze the population of pregnant women in Bulgaria regarding the main parameters that are relevant to their thyroid status - age, sequence of pregnancy, reproductive problems, family history of thyroid disease, body mass index. Material: We studied 547 pregnant women, mean age 30±5 years. The study was conducted as a cross-sectional multicenter population-based in 10 regions of Bulgaria or a total of 84 settlements. Methods: An individual Questionnaire was completed, determined in a central laboratory with ECLIA method TSH, FT4, TPOAb and ultrasound examination of the cervical region was conducted. Statistical processing of the material was performed using the standard SPSS 13.0 for Windows. Results: TSH levels are negatively correlated with age, PConclusion: The preliminary in-depth study and presentation of the characteristics of the studied Bulgarian population of pregnant women is the basis for a proper assessment of the condition of the thyroid gland.},
year = {2020}
}
TY - JOUR T1 - Factors Determining Thyroid Status in Pregnant Women in Bulgaria AU - Anna-Maria Borissova AU - Boyana Trifonova AU - Lilia Dakovska AU - Eugenia Michaylova AU - Mircho Vukov Y1 - 2020/12/31 PY - 2020 N1 - https://doi.org/10.11648/j.ijde.20200504.17 DO - 10.11648/j.ijde.20200504.17 T2 - International Journal of Diabetes and Endocrinology JF - International Journal of Diabetes and Endocrinology JO - International Journal of Diabetes and Endocrinology SP - 89 EP - 95 PB - Science Publishing Group SN - 2640-1371 UR - https://doi.org/10.11648/j.ijde.20200504.17 AB - Thyroid dysfunction occurs in 5-18% of pregnant women and is associated with a higher risk of various gynecological and obstetric complications and these differences are due to the specific characteristic of the study population. The aim of the present study is to analyze the population of pregnant women in Bulgaria regarding the main parameters that are relevant to their thyroid status - age, sequence of pregnancy, reproductive problems, family history of thyroid disease, body mass index. Material: We studied 547 pregnant women, mean age 30±5 years. The study was conducted as a cross-sectional multicenter population-based in 10 regions of Bulgaria or a total of 84 settlements. Methods: An individual Questionnaire was completed, determined in a central laboratory with ECLIA method TSH, FT4, TPOAb and ultrasound examination of the cervical region was conducted. Statistical processing of the material was performed using the standard SPSS 13.0 for Windows. Results: TSH levels are negatively correlated with age, PConclusion: The preliminary in-depth study and presentation of the characteristics of the studied Bulgarian population of pregnant women is the basis for a proper assessment of the condition of the thyroid gland. VL - 5 IS - 4 ER -
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