In Prediabetes blood sugar levels are found to be higher than normal levels. It is considered as pre stage of diabetes as people with prediabetes, if remain undiagnosed, have chances of developing type 2 diabetes. Studies show that if diabetes is treated in the prediabetic stage, it results in complete cure of diabetes. The objective of the present study was to investigate effect of PDBT capsules containing extracts of well-known Ayurvedic plants such as Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester, and Momordica charantia on prediabetic condition induced in Wistar rats. High fat fructose diet was fed to male Wistar rats to induce prediabetes. After induction on 11th week of study, the prediabetic rats were divided in different groups. Treatment groups received Pioglitazone (3 mg/kg) (standard control), test formulation, PDBT capsule (200mg/kg) (test group) along with high fat fructose diet. Normal diet control group received normal diet and high fat fructose diet control group received only high fat fructose diet. The different biochemical parameters, blood glucose levels and body weights were monitored. Animals were sacrificed at the end of study period. Histopathological studies on the major organs such as liver, kidney, pancreas was performed. High fat fructose diet induced of prediabetes in rats. Significant decrease in levels of fasting blood glucose and biochemical parameters in treatment groups was observed. The histopathological study showed no abnormalities. The present research show that PDBT capsules can be efficiently used in prediabetes treatment. Hence, PDBT capsule can be a potential agent for the treatment of prediabetes.
| Published in | International Journal of Diabetes and Endocrinology (Volume 6, Issue 1) |
| DOI | 10.11648/j.ijde.20210601.14 |
| Page(s) | 16-23 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Prediabetes, Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester, Momordica charantia
| [1] | Piero M, Nzaro G, Njagi J. Diabetes mellitus – a devastating metabolic disorder. Asian Journal of Biomedical and Pharmaceutical Sciences 2014; 04 (40): 1-7. |
| [2] | Catherine C. Diabetes-Vital Statistics. USA: American Diabetes Association 1996: 65-80. |
| [3] | Tabák A, Herder C, Rathmann W, Brunner E, Kivimäki M. Prediabetes: a high-risk state for diabetes development. Lancet 2012; 379: 2279–90. |
| [4] | Ray J. Gestational prediabetes: a new term for early prevention? Indian J Med Res. 2010; 132: 251-255. |
| [5] | Kristine H. Allin et al Aberrant intestinal microbiota in individuals with prediabetes Diabetologia 2018; 61: 810–820. |
| [6] | Z. Punthakee et al. Clinical Practice Guidelines Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome Can J Diabetes 2018; 42: S10–S15. |
| [7] | Kristian Rett & Ulrike Hostalek Understanding prediabetes: definition, prevalence, burden and treatment options for an emerging diseas, Current Medical Research and Opinion 2019; 35 (9): 1529-1534. |
| [8] | Boyle J, Thompson T, Gregg E, Barker L, Williamson D. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Population Health Metrics 2010; 8: 29. |
| [9] | International Diabetes Federation. IDF Diabetes Atlas, 7th edn. Brussels, Belgium: International Diabetes Federation, 2015. www.diabetesatlas.org. |
| [10] | WHO, International Diabetes Foundation. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation. Geneva: World Health Organization, 2006. |
| [11] | Rang and Dales’s Pharmacology sixth edition, Churchill livingstone p. 397-409. |
| [12] | Fabricant D, Farnsworth N. The Value of Plants Used in Traditional Medicine for Drug Discovery. Environmental Health Perspectives 2001; Suppl 1 (109): 69-75. |
| [13] | Middha S, Mittal Y, Usha T, Dharmendra Kumar, Srinivasan R, Vashisth L, et al. Phyto-mellitus: A phyto-chemical database for diabetes. Bioinformation 2009; 4 (2): 78-79. |
| [14] | Tiwari A, Rao J, Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects. Current Science 2002; 83, (1): 30-38. |
| [15] | Ngan T, Bao P and Ly L. Review Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery Biology 2020; 9: 252; doi: 10.3390/biology9090252. |
| [16] | Ashok D. B. Vaidya, Thomas P. Devasagayam. Current Status of Herbal Drugs in India: An Overview J. Clin. Biochem. Nutr., 2007; 41: 1–11. |
| [17] | Zainab M. Al-Amin, Martha Thomson, Khaled K. Al-Qattan, Riitta Peltonen-Shalaby and Muslim Ali Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. British Journal of Nutrition 2006; 96: 660–666. |
| [18] | M. Manickam, M. Ramanathan, M. A. Farboodniay Jahromi, J. P. N. Chansouria, and A. B. Ray Antihyperglycemic Activity of Phenolics from Pterocarpus marsupium J. Nat. Prod. 1997; 60: 609-610. |
| [19] | Shanmugasundaram ER, Gopinath KL, Radha Shanmugasundaram K, Rajendran VM. Possible regeneration of the islets of langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts Journal of Ethnopharmacology 1990; 30 (3): 265-279. |
| [20] | E Basch, S Gabardi and C Ulbricht Bitter melon (Momordica charantia): a review of efficacy and safety, American Journal of Health-System Pharmacy February 2003, 60 (4) 356-359. |
| [21] | P. Stanely, Mainzen Prince, Venugopal P. Menon Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats Journal of Ethnopharmacology 2000; 70: 9–15. |
| [22] | Takeshi O, Katsuhiro M, Takahisa Y. Pathoic physiological Changes in Pre-Diabetic Torii (SDT) Rats. Journal of Animal and Veterinary Advances 2011; 10 (7): 813-817. |
| [23] | Pratley R, Matfin G. Pre-diabetes: clinical relevance and therapeutic approach. The British Journal of Diabetes & Vascular Disease 2007; 7 (3S): 119-129. |
| [24] | Patwardhan B. Ethnopharmacology and drug discovery. Journal of Ethnopharmacology 2005; 100: 50–52. |
| [25] | Cohen M, A. Teitelbaum, and E. Rosenman. Diabetes Induced by a High Fructose Diet Metabolism1977; 26 (1): 17-24. |
| [26] | Chinnadurai V, Mohammed A. Alsaif and Khalid S., Al-Numair, Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes. Chemico-Biological Interactions 2018; 288: 49-56. |
| [27] | Russel J. C., Procter S. D. Small animal models of CVD: tool for the study of the roles of metabolic syndrome, dyslipidaemia and atherosclerosis. Cardiovascular pathology 2006; 15: 318-330. |
| [28] | Hígado graso no alcohólico y diabetes, Non-alcoholic fatty liver disease and diabetes, Med Clin (Barc). 2017; 148 (1): 33–38. |
| [29] | Rexford A. Connecting obesity, aging and diabetes. Nature Medicine 2009; 15: 996-997. |
| [30] | Collino M, Aragno M, Castiglia S, Gianluca Miglio, Chiara Tomasinelli, Giuseppe Boccuzzi, et al. Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation. British Journal of Pharmacology 2010; 160 (8): 1892–1902. |
| [31] | Liu I, Tzeng T, Liou S, Chang C. Angelica acutiloba Root Attenuates Insulin Resistance. Phytotherapy Research 2011; 25: 1283–1293. |
| [32] | Moghadasian M. H. Experimental atherosclerosis, A historical overview. Life sciences 2002; 70: 855-865. |
| [33] | Mohammad Minhajuddin, Zafarul H. Beg, Jahangir Iqbal. Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food and Chemical Toxicology 2005; 43: 747–753. |
| [34] | Pas´koa P, Barton H, Zagrodzkia P, Gorinstein S. Effect of amaranth seeds (Amaranthus cruentus) in the diet on some biochemical parameters and essential trace elements in blood of high fructose-fed rats. Natural Product Research 2011; 25 (8): 844–849. |
APA Style
Pallavi Londhe, Rohini Waghmare, Amit Nakanekar, Kuldip Kohli, Pratima Arun Tatke. (2021). Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes. International Journal of Diabetes and Endocrinology, 6(1), 16-23. https://doi.org/10.11648/j.ijde.20210601.14
ACS Style
Pallavi Londhe; Rohini Waghmare; Amit Nakanekar; Kuldip Kohli; Pratima Arun Tatke. Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes. Int. J. Diabetes Endocrinol. 2021, 6(1), 16-23. doi: 10.11648/j.ijde.20210601.14
AMA Style
Pallavi Londhe, Rohini Waghmare, Amit Nakanekar, Kuldip Kohli, Pratima Arun Tatke. Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes. Int J Diabetes Endocrinol. 2021;6(1):16-23. doi: 10.11648/j.ijde.20210601.14
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Download@article{10.11648/j.ijde.20210601.14,
author = {Pallavi Londhe and Rohini Waghmare and Amit Nakanekar and Kuldip Kohli and Pratima Arun Tatke},
title = {Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes},
journal = {International Journal of Diabetes and Endocrinology},
volume = {6},
number = {1},
pages = {16-23},
doi = {10.11648/j.ijde.20210601.14},
url = {https://doi.org/10.11648/j.ijde.20210601.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210601.14},
abstract = {In Prediabetes blood sugar levels are found to be higher than normal levels. It is considered as pre stage of diabetes as people with prediabetes, if remain undiagnosed, have chances of developing type 2 diabetes. Studies show that if diabetes is treated in the prediabetic stage, it results in complete cure of diabetes. The objective of the present study was to investigate effect of PDBT capsules containing extracts of well-known Ayurvedic plants such as Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester, and Momordica charantia on prediabetic condition induced in Wistar rats. High fat fructose diet was fed to male Wistar rats to induce prediabetes. After induction on 11th week of study, the prediabetic rats were divided in different groups. Treatment groups received Pioglitazone (3 mg/kg) (standard control), test formulation, PDBT capsule (200mg/kg) (test group) along with high fat fructose diet. Normal diet control group received normal diet and high fat fructose diet control group received only high fat fructose diet. The different biochemical parameters, blood glucose levels and body weights were monitored. Animals were sacrificed at the end of study period. Histopathological studies on the major organs such as liver, kidney, pancreas was performed. High fat fructose diet induced of prediabetes in rats. Significant decrease in levels of fasting blood glucose and biochemical parameters in treatment groups was observed. The histopathological study showed no abnormalities. The present research show that PDBT capsules can be efficiently used in prediabetes treatment. Hence, PDBT capsule can be a potential agent for the treatment of prediabetes.},
year = {2021}
}
TY - JOUR T1 - Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes AU - Pallavi Londhe AU - Rohini Waghmare AU - Amit Nakanekar AU - Kuldip Kohli AU - Pratima Arun Tatke Y1 - 2021/01/18 PY - 2021 N1 - https://doi.org/10.11648/j.ijde.20210601.14 DO - 10.11648/j.ijde.20210601.14 T2 - International Journal of Diabetes and Endocrinology JF - International Journal of Diabetes and Endocrinology JO - International Journal of Diabetes and Endocrinology SP - 16 EP - 23 PB - Science Publishing Group SN - 2640-1371 UR - https://doi.org/10.11648/j.ijde.20210601.14 AB - In Prediabetes blood sugar levels are found to be higher than normal levels. It is considered as pre stage of diabetes as people with prediabetes, if remain undiagnosed, have chances of developing type 2 diabetes. Studies show that if diabetes is treated in the prediabetic stage, it results in complete cure of diabetes. The objective of the present study was to investigate effect of PDBT capsules containing extracts of well-known Ayurvedic plants such as Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester, and Momordica charantia on prediabetic condition induced in Wistar rats. High fat fructose diet was fed to male Wistar rats to induce prediabetes. After induction on 11th week of study, the prediabetic rats were divided in different groups. Treatment groups received Pioglitazone (3 mg/kg) (standard control), test formulation, PDBT capsule (200mg/kg) (test group) along with high fat fructose diet. Normal diet control group received normal diet and high fat fructose diet control group received only high fat fructose diet. The different biochemical parameters, blood glucose levels and body weights were monitored. Animals were sacrificed at the end of study period. Histopathological studies on the major organs such as liver, kidney, pancreas was performed. High fat fructose diet induced of prediabetes in rats. Significant decrease in levels of fasting blood glucose and biochemical parameters in treatment groups was observed. The histopathological study showed no abnormalities. The present research show that PDBT capsules can be efficiently used in prediabetes treatment. Hence, PDBT capsule can be a potential agent for the treatment of prediabetes. VL - 6 IS - 1 ER -
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