Osteogenesis imperfecta (OI) is a hereditary disorder characterized by increased tendency for bone fractures due to high fragility. The clinical and radiological features of OI manifest in different age groups, although the disease is congenital in nature. Clinical manifestation of OI included laxity of the ligaments, blue sclera, growth retardation, and scoliosis. The most important oral finding in OI is the presence of yellowish-brown-colored brittle teeth characteristic of dentinogenesis imperfecta. A 13 years-old male brought to hospital with chief complaints of fracture upper and lower limbs. The fractures due to minor trauma when he felled from standing position. He also complained about dentition. Teething is said to be disturbed, imperfect and brown colour. Radiology examination showed complete fracture et regio left femur. Bone Marrow Density examination showed low bone mass. Laboratory examination showed hypocalcemia, vitamin D insufficiency and normal parathyroid hormone. On the 5th days of hospitalization patient got surgery from orthopedic specialist for primary treatment of the fracture. The others treatment were given included zolendronat acid, calcitriol and calcium carbonate medication until patient discharged from hospital. Osteogenesis imperfecta could be treated and had well prognostic with the early diagnosed and proper treatment. Management of osteogenesis imperfecta involve multidisciplinary such as pediatric endocrinologists, orthopedics, medical rehabilitation, child development and nutrition.
| Published in | International Journal of Diabetes and Endocrinology (Volume 6, Issue 1) |
| DOI | 10.11648/j.ijde.20210601.16 |
| Page(s) | 31-35 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Osteogenesis Imperfecta, Pathologic Fracture, Vitamin D Deficiency
| [1] | Trejo P, Rauch F. Osteogenesis imperfect in children and adolescents - New developments in diagnosis and treatment. Osteoporos Int. 2016; 27: 3427–37. |
| [2] | Bethesda. Osteogenesis imerfecta overview- Osteoporosis and related bone disease. National Institutes of Health. 2015. |
| [3] | Hoyer-Kuhn H, Netzer C, Semler O. Osteogenesis imperfecta: pathophysiology and treatment. Wien Med Wochenschr. 2015; 165: 278-84. |
| [4] | Forlino A, Marini JC. Osteogenesis imperfecta. Lancet. 2016; 387: 1657-71. |
| [5] | Starr SR, Timothy T, Fischer R, Fischer PR. Osteogenesis imperfect: Primary care. Pediatr in Rev. 2010; 31: 54-64. |
| [6] | Sormova L, Mazura I. Osteogenesis imperfect type I-IV, the collagenous disorders of connective tissue in Czech population. EJBI. 2011; 7: 59-64. |
| [7] | Rauch F, Glorieux F. Osteogenesis imperfecta. Lancet. 2004; 363: 1377-85. |
| [8] | Lee JY, So TY, Thackray J. A review on vitamin D deficiency treatment in pediatric patients. JPPT. 2013; 18 (4): 277-91. |
| [9] | Kadhim M, Holmes L, Bober MB, Rogers KJ, Kallur A, Davey L, et al. Vitamin D status in pediatric patients with osteogenesis imperfecta. Pediatrics & Therapeutics. 2011; 1 (2): 2-5. |
| [10] | Edouard T, Glorieux FH, Rauch F. Predictors and cooelates of vitamin D status in Children and adolescents with osteogenesis imperfecta. 2011; 96 (10): 3193-8. |
| [11] | Antoniazzi F, Monti E, Mottes M, Fraschini P, Brunelli P, Forlino A, et al. Current and emerging treatments for the management of osteogenesis imperfecta. Ther Clin Risk Manag. 2010; 6: 367–81. |
| [12] | Zerwekh JE. Blood biomarkers of vitamin D status. Am. J. Clin. Nutr. 2008; 87: 1087-91. |
| [13] | George S, Weber DR, Kaplan P, Hummel K, Monk HM, Levine MA. Short-term safety of zoledronic acid in young patients with bone disorders: an extensive institutional experience. J Clin Endocrinol Metab. 2015; 100 (11): 4163-171. |
| [14] | Astrom E, Soderhall S. Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta. Arch Dis Child. 2002; 86: 356-64. |
| [15] | Engelbert RH, Uiterwaal CS, Gerver WJ, Net JJ, Pruijs HE, Helders PJ. Osteogenesis imperfecta in childhood: Impairment and disability. a prospective study with 4-year follow-up. Archives of Physical Medicine and Rehabilitation. 2004; 85 (5): 772-8. |
APA Style
Arya Wisnu Prayoga, I Made Arimbawa, I Wayan Bikin Suryawan, I Made Dharma Yuda. (2021). Pathologic Fracture and Vitamin D Deficiency in Pediatric Patient with Osteogenesis Imperfecta Type IV. International Journal of Diabetes and Endocrinology, 6(1), 31-35. https://doi.org/10.11648/j.ijde.20210601.16
ACS Style
Arya Wisnu Prayoga; I Made Arimbawa; I Wayan Bikin Suryawan; I Made Dharma Yuda. Pathologic Fracture and Vitamin D Deficiency in Pediatric Patient with Osteogenesis Imperfecta Type IV. Int. J. Diabetes Endocrinol. 2021, 6(1), 31-35. doi: 10.11648/j.ijde.20210601.16
AMA Style
Arya Wisnu Prayoga, I Made Arimbawa, I Wayan Bikin Suryawan, I Made Dharma Yuda. Pathologic Fracture and Vitamin D Deficiency in Pediatric Patient with Osteogenesis Imperfecta Type IV. Int J Diabetes Endocrinol. 2021;6(1):31-35. doi: 10.11648/j.ijde.20210601.16
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Download@article{10.11648/j.ijde.20210601.16,
author = {Arya Wisnu Prayoga and I Made Arimbawa and I Wayan Bikin Suryawan and I Made Dharma Yuda},
title = {Pathologic Fracture and Vitamin D Deficiency in Pediatric Patient with Osteogenesis Imperfecta Type IV},
journal = {International Journal of Diabetes and Endocrinology},
volume = {6},
number = {1},
pages = {31-35},
doi = {10.11648/j.ijde.20210601.16},
url = {https://doi.org/10.11648/j.ijde.20210601.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210601.16},
abstract = {Osteogenesis imperfecta (OI) is a hereditary disorder characterized by increased tendency for bone fractures due to high fragility. The clinical and radiological features of OI manifest in different age groups, although the disease is congenital in nature. Clinical manifestation of OI included laxity of the ligaments, blue sclera, growth retardation, and scoliosis. The most important oral finding in OI is the presence of yellowish-brown-colored brittle teeth characteristic of dentinogenesis imperfecta. A 13 years-old male brought to hospital with chief complaints of fracture upper and lower limbs. The fractures due to minor trauma when he felled from standing position. He also complained about dentition. Teething is said to be disturbed, imperfect and brown colour. Radiology examination showed complete fracture et regio left femur. Bone Marrow Density examination showed low bone mass. Laboratory examination showed hypocalcemia, vitamin D insufficiency and normal parathyroid hormone. On the 5th days of hospitalization patient got surgery from orthopedic specialist for primary treatment of the fracture. The others treatment were given included zolendronat acid, calcitriol and calcium carbonate medication until patient discharged from hospital. Osteogenesis imperfecta could be treated and had well prognostic with the early diagnosed and proper treatment. Management of osteogenesis imperfecta involve multidisciplinary such as pediatric endocrinologists, orthopedics, medical rehabilitation, child development and nutrition.},
year = {2021}
}
TY - JOUR T1 - Pathologic Fracture and Vitamin D Deficiency in Pediatric Patient with Osteogenesis Imperfecta Type IV AU - Arya Wisnu Prayoga AU - I Made Arimbawa AU - I Wayan Bikin Suryawan AU - I Made Dharma Yuda Y1 - 2021/01/28 PY - 2021 N1 - https://doi.org/10.11648/j.ijde.20210601.16 DO - 10.11648/j.ijde.20210601.16 T2 - International Journal of Diabetes and Endocrinology JF - International Journal of Diabetes and Endocrinology JO - International Journal of Diabetes and Endocrinology SP - 31 EP - 35 PB - Science Publishing Group SN - 2640-1371 UR - https://doi.org/10.11648/j.ijde.20210601.16 AB - Osteogenesis imperfecta (OI) is a hereditary disorder characterized by increased tendency for bone fractures due to high fragility. The clinical and radiological features of OI manifest in different age groups, although the disease is congenital in nature. Clinical manifestation of OI included laxity of the ligaments, blue sclera, growth retardation, and scoliosis. The most important oral finding in OI is the presence of yellowish-brown-colored brittle teeth characteristic of dentinogenesis imperfecta. A 13 years-old male brought to hospital with chief complaints of fracture upper and lower limbs. The fractures due to minor trauma when he felled from standing position. He also complained about dentition. Teething is said to be disturbed, imperfect and brown colour. Radiology examination showed complete fracture et regio left femur. Bone Marrow Density examination showed low bone mass. Laboratory examination showed hypocalcemia, vitamin D insufficiency and normal parathyroid hormone. On the 5th days of hospitalization patient got surgery from orthopedic specialist for primary treatment of the fracture. The others treatment were given included zolendronat acid, calcitriol and calcium carbonate medication until patient discharged from hospital. Osteogenesis imperfecta could be treated and had well prognostic with the early diagnosed and proper treatment. Management of osteogenesis imperfecta involve multidisciplinary such as pediatric endocrinologists, orthopedics, medical rehabilitation, child development and nutrition. VL - 6 IS - 1 ER -
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