Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program

Gurdeep Singh; Matthew Krauthamer; Meghan Bjalme-Evans

doi:doi:10.11648/j.ijde.20210604.17

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Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program

Gurdeep Singh, Matthew Krauthamer, Meghan Bjalme-Evans

Published in International Journal of Diabetes and Endocrinology (Volume 6, Issue 4)

Received: 27 November 2021 Accepted: 14 December 2021 Published: 24 December 2021

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Abstract

Background: The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) clinical trial program was a phase III, multinational, multicenter program comprising 13 trials. Objective: Investigate the safety and efficacy of once-weekly, subcutaneous semaglutide versus other antidiabetic comparators, both as a monotherapy and in addition to other antidiabetic medications. Methods: This review summarizes the 10 trials that comprise the bulk of the evidence which led to FDA approval of semaglutide as an antidiabetic drug. Most articles were accessed via the National Center for Biotechnology Information database using pertinent search terms. Results: Semaglutide 0.5 mg and 1 mg weekly subcutaneous injection led to HA1c reductions by 1.1%–1.5% and 1.5%–1.8%, respectively. Bodyweight reduction with 0.5 mg and 1 mg dose of semaglutide ranged from 3.47–4.6 kg and 4.53–6.5 kg, respectively. SUSTAIN 6, in particular, found cardiovascular risk factor benefits, including the rate of nonfatal myocardial infarction, cardiovascular death and nonfatal strokes in high-risk patients correlated with the use of semaglutide in patients with type 2 diabetes. Conclusions: Semaglutide is superior to other glucagon-like peptide-1 receptor agonists, including exenatide, dulaglutide, and liraglutide in hemoglobin A1c reduction. It is also helpful for chronic weight loss and has cardioprotective effects.

Published in	International Journal of Diabetes and Endocrinology (Volume 6, Issue 4)
DOI	10.11648/j.ijde.20210604.17
Page(s)	167-174
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Semaglutide, SUSTAIN, Incretin Therapy, GLP-1 Analog, Antidiabetic Therapy, Type Two Diabetes

References

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[30]	DeVries JH, Desouza C, Bellary S, Unger J, Hansen OK, Zacho J, et al. Achieving glycaemic control without weight gain, hypoglycemia, or gastrointestinal adverse events in type 2 diabetes in the SUSTAIN clinical trial programme. Diabetes Obes Metab. 2018; 20: 2426–2434. https://doi: 10.1111/dom.13396.

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APA Style

Gurdeep Singh, Matthew Krauthamer, Meghan Bjalme-Evans. (2021). Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program. International Journal of Diabetes and Endocrinology, 6(4), 167-174. https://doi.org/10.11648/j.ijde.20210604.17

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ACS Style

Gurdeep Singh; Matthew Krauthamer; Meghan Bjalme-Evans. Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program. Int. J. Diabetes Endocrinol. 2021, 6(4), 167-174. doi: 10.11648/j.ijde.20210604.17

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AMA Style

Gurdeep Singh, Matthew Krauthamer, Meghan Bjalme-Evans. Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program. Int J Diabetes Endocrinol. 2021;6(4):167-174. doi: 10.11648/j.ijde.20210604.17

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@article{10.11648/j.ijde.20210604.17,
  author = {Gurdeep Singh and Matthew Krauthamer and Meghan Bjalme-Evans},
  title = {Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {6},
  number = {4},
  pages = {167-174},
  doi = {10.11648/j.ijde.20210604.17},
  url = {https://doi.org/10.11648/j.ijde.20210604.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210604.17},
  abstract = {Background: The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) clinical trial program was a phase III, multinational, multicenter program comprising 13 trials. Objective: Investigate the safety and efficacy of once-weekly, subcutaneous semaglutide versus other antidiabetic comparators, both as a monotherapy and in addition to other antidiabetic medications. Methods: This review summarizes the 10 trials that comprise the bulk of the evidence which led to FDA approval of semaglutide as an antidiabetic drug. Most articles were accessed via the National Center for Biotechnology Information database using pertinent search terms. Results: Semaglutide 0.5 mg and 1 mg weekly subcutaneous injection led to HA1c reductions by 1.1%–1.5% and 1.5%–1.8%, respectively. Bodyweight reduction with 0.5 mg and 1 mg dose of semaglutide ranged from 3.47–4.6 kg and 4.53–6.5 kg, respectively. SUSTAIN 6, in particular, found cardiovascular risk factor benefits, including the rate of nonfatal myocardial infarction, cardiovascular death and nonfatal strokes in high-risk patients correlated with the use of semaglutide in patients with type 2 diabetes. Conclusions: Semaglutide is superior to other glucagon-like peptide-1 receptor agonists, including exenatide, dulaglutide, and liraglutide in hemoglobin A1c reduction. It is also helpful for chronic weight loss and has cardioprotective effects.},
 year = {2021}
}

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TY  - JOUR
T1  - Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program
AU  - Gurdeep Singh
AU  - Matthew Krauthamer
AU  - Meghan Bjalme-Evans
Y1  - 2021/12/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ijde.20210604.17
DO  - 10.11648/j.ijde.20210604.17
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 167
EP  - 174
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20210604.17
AB  - Background: The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) clinical trial program was a phase III, multinational, multicenter program comprising 13 trials. Objective: Investigate the safety and efficacy of once-weekly, subcutaneous semaglutide versus other antidiabetic comparators, both as a monotherapy and in addition to other antidiabetic medications. Methods: This review summarizes the 10 trials that comprise the bulk of the evidence which led to FDA approval of semaglutide as an antidiabetic drug. Most articles were accessed via the National Center for Biotechnology Information database using pertinent search terms. Results: Semaglutide 0.5 mg and 1 mg weekly subcutaneous injection led to HA1c reductions by 1.1%–1.5% and 1.5%–1.8%, respectively. Bodyweight reduction with 0.5 mg and 1 mg dose of semaglutide ranged from 3.47–4.6 kg and 4.53–6.5 kg, respectively. SUSTAIN 6, in particular, found cardiovascular risk factor benefits, including the rate of nonfatal myocardial infarction, cardiovascular death and nonfatal strokes in high-risk patients correlated with the use of semaglutide in patients with type 2 diabetes. Conclusions: Semaglutide is superior to other glucagon-like peptide-1 receptor agonists, including exenatide, dulaglutide, and liraglutide in hemoglobin A1c reduction. It is also helpful for chronic weight loss and has cardioprotective effects.
VL  - 6
IS  - 4
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Author Information

Gurdeep Singh

Our Lady of Lourdes Memorial Hospital, Binghamton, New York, USA
Matthew Krauthamer

Our Lady of Lourdes Memorial Hospital, Binghamton, New York, USA
Meghan Bjalme-Evans

Our Lady of Lourdes Memorial Hospital, Binghamton, New York, USA

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Gurdeep Singh, Matthew Krauthamer, Meghan Bjalme-Evans. (2021). Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program. International Journal of Diabetes and Endocrinology, 6(4), 167-174. https://doi.org/10.11648/j.ijde.20210604.17

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ACS Style

Gurdeep Singh; Matthew Krauthamer; Meghan Bjalme-Evans. Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program. Int. J. Diabetes Endocrinol. 2021, 6(4), 167-174. doi: 10.11648/j.ijde.20210604.17

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AMA Style

Gurdeep Singh, Matthew Krauthamer, Meghan Bjalme-Evans. Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program. Int J Diabetes Endocrinol. 2021;6(4):167-174. doi: 10.11648/j.ijde.20210604.17

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@article{10.11648/j.ijde.20210604.17,
  author = {Gurdeep Singh and Matthew Krauthamer and Meghan Bjalme-Evans},
  title = {Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {6},
  number = {4},
  pages = {167-174},
  doi = {10.11648/j.ijde.20210604.17},
  url = {https://doi.org/10.11648/j.ijde.20210604.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210604.17},
  abstract = {Background: The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) clinical trial program was a phase III, multinational, multicenter program comprising 13 trials. Objective: Investigate the safety and efficacy of once-weekly, subcutaneous semaglutide versus other antidiabetic comparators, both as a monotherapy and in addition to other antidiabetic medications. Methods: This review summarizes the 10 trials that comprise the bulk of the evidence which led to FDA approval of semaglutide as an antidiabetic drug. Most articles were accessed via the National Center for Biotechnology Information database using pertinent search terms. Results: Semaglutide 0.5 mg and 1 mg weekly subcutaneous injection led to HA1c reductions by 1.1%–1.5% and 1.5%–1.8%, respectively. Bodyweight reduction with 0.5 mg and 1 mg dose of semaglutide ranged from 3.47–4.6 kg and 4.53–6.5 kg, respectively. SUSTAIN 6, in particular, found cardiovascular risk factor benefits, including the rate of nonfatal myocardial infarction, cardiovascular death and nonfatal strokes in high-risk patients correlated with the use of semaglutide in patients with type 2 diabetes. Conclusions: Semaglutide is superior to other glucagon-like peptide-1 receptor agonists, including exenatide, dulaglutide, and liraglutide in hemoglobin A1c reduction. It is also helpful for chronic weight loss and has cardioprotective effects.},
 year = {2021}
}

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TY  - JOUR
T1  - Semaglutide as an Antidiabetic Medication: A Summary of the Evidence from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes Clinical Trial Program
AU  - Gurdeep Singh
AU  - Matthew Krauthamer
AU  - Meghan Bjalme-Evans
Y1  - 2021/12/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ijde.20210604.17
DO  - 10.11648/j.ijde.20210604.17
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 167
EP  - 174
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20210604.17
AB  - Background: The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) clinical trial program was a phase III, multinational, multicenter program comprising 13 trials. Objective: Investigate the safety and efficacy of once-weekly, subcutaneous semaglutide versus other antidiabetic comparators, both as a monotherapy and in addition to other antidiabetic medications. Methods: This review summarizes the 10 trials that comprise the bulk of the evidence which led to FDA approval of semaglutide as an antidiabetic drug. Most articles were accessed via the National Center for Biotechnology Information database using pertinent search terms. Results: Semaglutide 0.5 mg and 1 mg weekly subcutaneous injection led to HA1c reductions by 1.1%–1.5% and 1.5%–1.8%, respectively. Bodyweight reduction with 0.5 mg and 1 mg dose of semaglutide ranged from 3.47–4.6 kg and 4.53–6.5 kg, respectively. SUSTAIN 6, in particular, found cardiovascular risk factor benefits, including the rate of nonfatal myocardial infarction, cardiovascular death and nonfatal strokes in high-risk patients correlated with the use of semaglutide in patients with type 2 diabetes. Conclusions: Semaglutide is superior to other glucagon-like peptide-1 receptor agonists, including exenatide, dulaglutide, and liraglutide in hemoglobin A1c reduction. It is also helpful for chronic weight loss and has cardioprotective effects.
VL  - 6
IS  - 4
ER  -

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