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Effect of Exercise and Non-exercise Interventions on Cardiac Angiogenesis in Diabetes Mellitus Patients: A Review

Received: 9 December 2021    Accepted: 5 January 2022    Published: 17 January 2022
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Abstract

Background: It has been shown that about 80% of deaths in diabetic patients are due to cardiovascular disorders, which are called Diabetic Heart Disease or DHD, the most important of which are dysfunction and vascular damage, and consequently the stopping of coronary angiogenesis. Despite the many advances made in the field of medical research and the long-standing clinical history of diabetes mellitus, the risk of cardiovascular disease associated with diabetes has not been reduced. Method: Our search was performed by typing the words HIIT, MICT, Diabetic Heart Disease, MicroRNA, Cardiac Angiogenesis in pubmed. We reviewed the literature using articles that were relevant to our field of work. conclusion: Researchers have proposed different exercise programs to improve cardiovascular complications in diabetic patient, and their prominent role in improving the complications associated with microangiopathy compared to non-exercise interventions (hormone, complementary therapies, pharmaceutical methods, etc.) in these proven patients. but so far no study has been done to compare the effectiveness of exercise or non-exercise interventions on the improvement of microvascular complications in DHD patients. Therefore, this review article compares the types of interventions that affect the angiogenesis of patients with a history of DHD.

Published in International Journal of Diabetes and Endocrinology (Volume 7, Issue 1)
DOI 10.11648/j.ijde.20220701.11
Page(s) 1-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

HIIT, MICT, Diabetic Heart Disease, MicroRNA, Cardiac Angiogenesis

References
[1] Serra, Hector Alejandro, Cristian Suarez Cordo, Jorge Alvarinas, Julio César Bragagnolo, Gustavo Daniel Frechtel, Pilar Cean, Claudia Folino, Analía Dagum, and Susana Salzberg. "Transportadores celulares de drogas. El viaje de los antidiabéticos orales por el organismo." Revista de la Sociedad Argentina de Diabetes 51, no. 4 (2018): 137-152.
[2] World Health Organization, 2016 World report on diabetes. Access (04/06/18) in: http://apps.who.int/iris/bitstream/handle/10665/204877/WHONMHNVI16.3spa.pdf;jsessionid=18BF312190B708D0E9E97F7ED6137537?sequence=1.
[3] Lopez-Miranda, Jose, and Xavier Pinto. "Anti-PCSK9 antibodies in type 2 diabetes and secondary prevention of cardiovascular diseases." Clinica e investigacion en arteriosclerosis: publicacion oficial de la Sociedad Espanola de Arteriosclerosis 28 (2016): 31-38.
[4] Santos, Mario, Erin West, Hicham Skali, Daniel E. Forman, Wilson Nadruz Junior, and Amil M. Shah. "Resting heart rate and chronotropic response to exercise: prognostic implications in heart failure across the left ventricular ejection fraction spectrum." Journal of cardiac failure 24, no. 11 (2018): 753-762.
[5] Wright, Jordan J., Jaetaek Kim, Jonathan Buchanan, Sihem Boudina, Sandra Sena, Kyriaki Bakirtzi, Olesya Ilkun et al. "Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding." Cardiovascular research 82, no. 2 (2009): 351-360.
[6] Rawal, Shruti, Thrishila Parshu Ram, Sean Coffey, Michael JA Williams, Pankaj Saxena, Richard W. Bunton, Ivor F. Galvin, and Rajesh Katare. "Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction." International journal of cardiology 202 (2016): 40-43.
[7] Asmal, AC, Leary, WP & Thandroyen, F. "Diabetic heart disease." South African Medical Journal 57, no. 19 (1980): 788-790.
[8] de Cillis, Emanuela, Anna Leonardini, Luigi Laviola, Francesco Giorgino, and A. S. Bortone. "Different gene expression in human heart tissue and progenitor cells from control and diabetic subjects: relevance to the pathogenesis of human diabetic cardiomyopathy." Surgical technology international 19 (2010): 165-174.
[9] Diao, Xuehong, E. Shen, Xiaoxia Wang, and Bing Hu. "Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice." Molecular medicine reports 4, no. 4 (2011): 633-640.
[10] Small, Eric M., and Eric N. Olson. "Pervasive roles of microRNAs in cardiovascular biology." Nature 469, no. 7330 (2011): 336-342.
[11] nD Jr, DA Silva, Tiago Fernandes, URSULA P. Soci, ALEX WILLIAN Monteiro, M. Ian Phillips, and DE Oliveira EM. "Swimming training in rats increases cardiac MicroRNA-126 expression and angiogenesis." Medicine and science in sports and exercise 44, no. 8 (2012): 1453-1462.
[12] Carreno, Juan Eduardo, Felipe Apablaza, María Paz Ocaranza, and Jorge E. Jalil. "Cardiac hypertrophy: molecular and cellular events." Revista Española de Cardiología (English Edition) 59, no. 5 (2006): 473-486.
[13] Rask-Madsen, Christian, and George L. King. "Vascular complications of diabetes: mechanisms of injury and protective factors." Cell metabolism 17, no. 1 (2013): 20-33.
[14] Galiano, Robert D., Oren M. Tepper, Catherine R. Pelo, Kirit A. Bhatt, Matthew Callaghan, Nicholas Bastidas, Stuart Bunting, Hope G. Steinmetz, and Geoffrey C. Gurtner. "Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells." The American journal of pathology 164, no. 6 (2004): 1935-1947.
[15] Martin, Alexandra, Michael R. Komada, and David C. Sane. "Abnormal angiogenesis in diabetes mellitus." Medicinal research reviews 23, no. 2 (2003): 117-145.
[16] Waltenberger, Johannes. "Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications." Cardiovascular research 49, no. 3 (2001): 554-560.
[17] Carmeliet, Peter. "Angiogenesis in health and disease." Nature medicine 9, no. 6 (2003): 653-660.
[18] Szweda, Nikola, and Łukasz Łaczmański. "miRNA in type 2 diabetes." Clinical Diabetology 5, no. 3 (2016): 100-106.
[19] Wisloff, Ulrik, Asbjorn Stoylen, Jan P. Loennechen, Morten Bruvold, oivind Rognmo, Per Magnus Haram, Arnt Erik Tjønna et al. "Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study." Circulation 115, no. 24 (2007): 3086-3094.
[20] Gibala, Martin J., and Sean L. McGee. "Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain?." Exercise and sport sciences reviews 36, no. 2 (2008): 58-63.
[21] Rad, Reza Sabzevari, Hossein Shirvani, Hamideh Mahmoodzadeh Hosseini, Alireza Shamsoddini, and Mohammad Samadi. "Micro RNA-126 promoting angiogenesis in diabetic heart by VEGF/Spred-1/Raf-1 pathway: effects of high-intensity interval training." Journal of Diabetes & Metabolic Disorders 19, no. 2 (2020): 1089-1096.
[22] McCall, G. E., W. C. Byrnes, A. Dickinson, P. M. Pattany, and S. J. Fleck. "Muscle fiber hypertrophy, hyperplasia, and capillary density in college men after resistance training." Journal of applied physiology 81, no. 5 (1996): 2004-2012.
[23] Rufaihah, Abdul Jalil, and Dror Seliktar. "Hydrogels for therapeutic cardiovascular angiogenesis." Advanced drug delivery reviews 96 (2016): 31-39.
[24] Falcon, Beverly L., Sudhakar Chintharlapalli, Mark T. Uhlik, and Bronislaw Pytowski. "Antagonist antibodies to vascular endothelial growth factor receptor 2 (VEGFR-2) as anti-angiogenic agents." Pharmacology & therapeutics 164 (2016): 204-225.
[25] Carmeliet, Peter, and Rakesh K. Jain. "Molecular mechanisms and clinical applications of angiogenesis." Nature 473, no. 7347 (2011): 298-307.
[26] Carmeliet, Peter. "Angiogenesis in life, disease and medicine." Nature 438, no. 7070 (2005): 932-936.
[27] Qin, Li, Jennifer L. Bromberg-White, and Chao-Nan Qian. "Opportunities and challenges in tumor angiogenesis research: back and forth between bench and bed." Advances in cancer research 113 (2012): 191-239.
[28] Potente, Michael, Holger Gerhardt, and Peter Carmeliet. "Basic and therapeutic aspects of angiogenesis." Cell 146, no. 6 (2011): 873-887.
[29] Bergers, Gabriele, and Douglas Hanahan. "Modes of resistance to anti-angiogenic therapy." Nature Reviews Cancer 8, no. 8 (2008): 592-603.
[30] Ribatti, Domenico. "Endogenous inhibitors of angiogenesis: a historical review." Leukemia research 33, no. 5 (2009): 638-644.
[31] Kuhnert, Frank, Michael R. Mancuso, Jessica Hampton, Kryn Stankunas, Tomoichiro Asano, Chang-Zheng Chen, and Calvin J. Kuo. "Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126." (2008): 3989-3993.
[32] Ye, Panpan, Jian Liu, Fengying He, Wen Xu, and Ke Yao. "Hypoxia-induced deregulation of miR-126 and its regulative effect on VEGF and MMP-9 expression." International journal of medical sciences 11, no. 1 (2014): 17.
[33] Liu, Bo, Xiao-Chun Peng, Xiao-Li Zheng, Jun Wang, and Yong-Wen Qin. "MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo." Lung cancer 66, no. 2 (2009): 169-175.
[34] Marwick, Thomas H. "The diabetic myocardium." Current diabetes reports 6, no. 1 (2006): 36-41.
[35] Nielsen, Roni, Helene Norrelund, Ulla Kampmann, Hans Erik Bøtker, Niels Moller, and Henrik Wiggers. "Effect of acute hyperglycemia on left ventricular contractile function in diabetic patients with and without heart failure: two randomized cross-over studies." PLoS One 8, no. 1 (2013): e53247.
[36] Chen, Victor, C. David Ianuzzo, Bing C. Fong, and John J. Spitzer. "The effects of acute and chronic diabetes on myocardial metabolism in rats." Diabetes 33, no. 11 (1984): 1078-1084.
[37] Waddingham, Mark T., Amanda J. Edgley, Hirotsugu Tsuchimochi, Darren J. Kelly, Mikiyasu Shirai, and James T. Pearson. "Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy." World journal of diabetes 6, no. 7 (2015): 943.
[38] American Heart Association National Institute of Health 2016; American Diabetes Association 2016; 1998; UK Prospective Diabetes Study (UKPDS) Group).
[39] Chistiakov, Dimitry A., Alexander N. Orekhov, and Yuri V. Bobryshev. "The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease." Journal of molecular and cellular cardiology 97 (2016): 47-55.
[40] Fish, Jason E., Massimo M. Santoro, Sarah U. Morton, Sangho Yu, Ru-Fang Yeh, Joshua D. Wythe, Kathryn N. Ivey, Benoit G. Bruneau, Didier YR Stainier, and Deepak Srivastava. "miR-126 regulates angiogenic signaling and vascular integrity." Developmental cell 15, no. 2 (2008): 272-284.
[41] Wang, Shusheng, Arin B. Aurora, Brett A. Johnson, Xiaoxia Qi, John McAnally, Joseph A. Hill, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson. "The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis." Developmental cell 15, no. 2 (2008): 261-271.
[42] Zernecke, Alma, Kiril Bidzhekov, Heidi Noels, Erdenechimeg Shagdarsuren, Lin Gan, Bernd Denecke, Mihail Hristov et al. "Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection." Science signaling 2, no. 100 (2009): ra81-ra81.
[43] Sessa, Roberto, Giorgio Seano, Laura Di Blasio, Paolo Armando Gagliardi, Claudio Isella, Enzo Medico, Franco Cotelli, Federico Bussolino, and Luca Primo. "The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β." Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823, no. 10 (2012): 1925-1935.
[44] Nicoli, Stefania, Clive Standley, Paul Walker, Adam Hurlstone, Kevin E. Fogarty, and Nathan D. Lawson. "MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis." Nature 464, no. 7292 (2010): 1196-1200.
[45] Jakob, Philipp, and Ulf Landmesser. "Role of microRNAs in stem/progenitor cells and cardiovascular repair." Cardiovascular research 93, no. 4 (2012): 614-622.
[46] Boulanger, Chantal M., Nicolas Amabile, and Alain Tedgui. "Circulating microparticles: a potential prognostic marker for atherosclerotic vascular disease." Hypertension 48, no. 2 (2006): 180-186.
[47] Staszel, Teresa, Barbara Zapała, Anna Polus, Anna Sadakierska-Chudy, Beata Kieć-Wilk, Ewa Stępień, Iwona Wybrańska, Monika Chojnacka, and Aldona Dembińska-Kieć. "Role of microRNAs in endothelial cell pathophysiology." Polskie Archiwum Medycyny Wewnętrznej 121, no. 10 (2011).
[48] Vickers, Kasey C., Brian T. Palmisano, Bassem M. Shoucri, Robert D. Shamburek, and Alan T. Remaley. "MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins." Nature cell biology 13, no. 4 (2011): 423-433.
[49] Meister, Jeannette, and Mirko HH Schmidt. "miR-126 and miR-126*: new players in cancer." The Scientific World JOURNAL 10 (2010): 2090-2100.
[50] Fichtlscherer, Stephan, Salvatore De Rosa, Henrik Fox, Thomas Schwietz, Ariane Fischer, Christoph Liebetrau, Michael Weber et al. "Circulating microRNAs in patients with coronary artery disease." Circulation research 107, no. 5 (2010): 677-684.
[51] Hamasaki, Hidetaka. "Interval exercise therapy for type 2 diabetes." Current diabetes reviews 14, no. 2 (2018): 129-137.
[52] Diabetes Prevention Program (DPP)., 2016; American Diabetes Association., 2016.
[53] Tjonna, Arnt Erik, Sang Jun Lee, oivind Rognmo, Tomas O. Stølen, Anja Bye, Per Magnus Haram, Jan Pål Loennechen et al. "Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study." Circulation 118, no. 4 (2008): 346-354.
[54] Albright, Ann, Marion Franz, Guyton Hornsby, Andrea Kriska, David Marrero, Irma Ullrich, and Larry S. Verity. "American College of Sports Medicine position stand. Exercise and type 2 diabetes." Medicine and science in sports and exercise 32, no. 7 (2000): 1345-1360.
[55] Okada, Sadanori, Aki Hiuge, Hisashi Makino, Ayako Nagumo, Hiroshi Takaki, Harumi Konishi, Yoichi Goto, Yasunao Yoshimasa, and Yoshihiro Miyamoto. "Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes." Journal of atherosclerosis and thrombosis (2010): 1005120226-1005120226.
[56] Gillen, J. B., J. P. Little, Z. Punthakee, M. A. Tarnopolsky, M. C. Riddell, and M. J. Gibala. "Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes." Diabetes, Obesity and Metabolism 14, no. 6 (2012): 575-577.
[57] Maillard, F., Sylvie Rousset, B. Pereira, Y. Boirie, M. Duclos, and Nathalie Boisseau. "High-intensity interval training is more effective than moderate-intensity continuous training in reducing abdominal fat mass in postmenopausal women with type 2 diabetes: a randomized crossover study." Diabetes Metab 44, no. 6 (2018): 516-517.
[58] Wormgoor, Shohn G., Lance C. Dalleck, Caryn Zinn, and Nigel K. Harris. "Effects of high-intensity interval training on people living with type 2 diabetes: a narrative review." Canadian journal of diabetes 41, no. 5 (2017): 536-547.
[59] Schjerve, Inga E., Gjertrud A. Tyldum, Arnt E. Tjønna, Tomas Stølen, Jan P. Loennechen, Harald EM Hansen, Per M. Haram et al. "Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults." Clinical science 115, no. 9 (2008): 283-293.
[60] Francois, Monique E., Cody Durrer, Kevin J. Pistawka, Frank A. Halperin, and Jonathan P. Little. "Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes." American Journal of Physiology-Heart and Circulatory Physiology 311, no. 5 (2016): H1258-H1267.
[61] Howden, Erin J., Satyam Sarma, Justin S. Lawley, Mildred Opondo, William Cornwell, Douglas Stoller, Marcus A. Urey, Beverley Adams-Huet, and Benjamin D. Levine. "Reversing the cardiac effects of sedentary aging in middle age—a randomized controlled trial: implications for heart failure prevention." Circulation 137, no. 15 (2018): 1549-1560.
[62] Maillard, F., Sylvie Rousset, B. Pereira, Amidou Traore, P. de Pradel Del Amaze, Yves Boirie, Martine Duclos, and N. Boisseau. "High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes." Diabetes & metabolism 42, no. 6 (2016): 433-441.
[63] Terada, Tasuku, Alanna Friesen, Baljot S. Chahal, Gordon J. Bell, Linda J. McCargar, and Normand G. Boulé. "Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes." Diabetes research and Clinical practice 99, no. 2 (2013): 120-129.
[64] Støa, Eva Maria, Sondre Meling, Lill-Katrin Nyhus, Glenn Strømstad, Karl Magnus Mangerud, Jan Helgerud, Solfrid Bratland-Sanda, and Øyvind Støren. "High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes." European journal of applied physiology 117, no. 3 (2017): 455-467.
[65] Zhang, N., J. Li, R. Luo, J. Jiang, and J-A. Wang. "Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy." Experimental and clinical endocrinology & diabetes 116, no. 02 (2008): 104-111.
[66] Dariushnejad, H., M. Mohammadi, and V. Ghorbanzadeh. "Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats." Bratislavske lekarske listy 119, no. 12 (2018): 757-761.
[67] Wang, Li, Qingwei Chen, Guiqiong Li, and Dazhi Ke. "Ghrelin ameliorates impaired angiogenesis of ischemic myocardium through GHSR1a-mediated AMPK/eNOS signal pathway in diabetic rats." Peptides 73 (2015): 77-87.
[68] Samuel, Samson Mathews, Yuzo Akita, Debayon Paul, Mahesh Thirunavukkarasu, Lijun Zhan, Perumana R. Sudhakaran, Chuanfu Li, and Nilanjana Maulik. "Coadministration of adenoviral vascular endothelial growth factor and angiopoietin-1 enhances vascularization and reduces ventricular remodeling in the infarcted myocardium of type 1 diabetic rats." Diabetes 59, no. 1 (2010): 51-60.
[69] Erekat, Nour S., Muhammed D. Al-Jarrah, and Ahed J. Al Khatib. "Treadmill exercise training improves vascular endothelial growth factor expression in the cardiac muscle of type I diabetic rats." Cardiology research 5, no. 1 (2014): 23.
[70] Simvastatin treatment inhibits hypoxia inducible factor 1-alpha-(HIF-1alpha)-prolyl-4-hydroxylase 3 (PHD-3) and increases angiogenesis after myocardial infarction in streptozotocin-induced diabetic ra.
[71] Shekarchizadeh, Esfahani P., R. Gharakhanlou, J. Karimian, A. Safarzade, and M. Khazaei. "Changes of plasma angiogenic factors during Chronic resistance exercise in Type I Diabetic Rats." Pakistan Journal of Medical Sciences 28, no. 2 (2012).
[72] Cassidy, Sophie, Vivek Vaidya, David Houghton, Pawel Zalewski, Jelena P. Seferovic, Kate Hallsworth, Guy A. MacGowan, Michael I. Trenell, and Djordje G. Jakovljevic. "Unsupervised high-intensity interval training improves glycaemic control but not cardiovascular autonomic function in type 2 diabetes patients: A randomised controlled trial." Diabetes and Vascular Disease Research 16, no. 1 (2019): 69-76.
[73] Yardley, Marianne, Thor Ueland, Pål Aukrust, Annika Michelsen, Elisabeth Bjørkelund, Lars Gullestad, and Kari Nytrøen. "Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients." Open heart 4, no. 2 (2017): e000635.
[74] Naderi, Roya, Gisou Mohaddes, Mustafa Mohammadi, Alireza Alihemmati, Amirmahdi Khamaneh, Rafighe Ghyasi, and Rana Ghaznavi. "The effect of garlic and voluntary exercise on cardiac angiogenesis in diabetes: the role of MiR-126 and MiR-210." Arquivos brasileiros de cardiologia 112 (2018): 154-162.
[75] Ghaffari-Nasab, Arshad, Fariba Mirzaie Bavil, Rafigheh Ghiasi, Saeed Sadigh-Eteghad, and Mohammad Reza Alipour. "Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats." Avicenna journal of phytomedicine 8, no. 2 (2018): 152.
[76] Chodari, L., Hassan Dariushnejad, and Vajihe Ghorbanzadeh. "Voluntary wheel running and testosterone replacement increases heart angiogenesis through miR-132 in castrated diabetic rats." Physiology international 106, no. 1 (2019): 48-58.
[77] Kandemir, Yasemin Behram, Veysel Tosun, Necmettin Korucuk, and Mehmet Nuri Bozdemir. "Melatonin protects against streptozotocin-induced diabetic cardiomyopathy by the phosphorylation of vascular endothelial growth factor-A (VEGF-A)." Cellular and Molecular Biology 64, no. 14 (2018): 47-52.
[78] Zampetaki, Anna, Stefan Kiechl, Ignat Drozdov, Peter Willeit, Ursula Mayr, Marianna Prokopi, Agnes Mayr et al. "Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes." Circulation research 107, no. 6 (2010): 810-817.
[79] Yi, Fan, Yuqiang Shang, Bing Li, Shilin Dai, Wei Wu, Long Cheng, and Xiancan Wang. "MicroRNA-193-5p modulates angiogenesis through IGF2 in type 2 diabetic cardiomyopathy." Biochemical and biophysical research communications 491, no. 4 (2017): 876-882.
[80] Dai, Yuxiang, Hao Lu, Shen Wang, Shufu Chang, Chenguang Li, Zheyong Huang, Feng Zhang et al. "MicroRNA-216b actively modulates diabetic angiopathy through inverse regulation on FZD5." Gene 658 (2018): 129-135.
[81] Gui, Chun, Zhi-yu Zeng, Qi Chen, Ya-wei Luo, Lang Li, and Lin-lin Chen. "Neuregulin-1 promotes myocardial angiogenesis in the rat model of diabetic cardiomyopathy." Cellular Physiology and Biochemistry 46, no. 6 (2018): 2325-2334.
[82] Khakdan, Soheyla, Maryam Delfan, Maryam Heydarpour Meymeh, Faranak Kazerouni, Hamid Ghaedi, Mehrnoosh Shanaki, Fatemeh Kalaki-Jouybari, Sattar Gorgani-Firuzjaee, and Ali Rahimipour. "High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats." Archives of physiology and biochemistry 126, no. 3 (2020): 250-257.
[83] Francois, Monique E., Kevin J. Pistawka, Frank A. Halperin, and Jonathan P. Little. "Cardiovascular benefits of combined interval training and post-exercise nutrition in type 2 diabetes." Journal of Diabetes and its Complications 32, no. 2 (2018): 226-233.
[84] Weston, Kassia S., Ulrik Wisløff, and Jeff S. Coombes. "High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis." British journal of sports medicine 48, no. 16 (2014): 1227-1234.
[85] Kravitz, Len, and Micah Zuhl. "High Intensity Interval Training vs. Continuous Cardio Training: Battle of the Aerobic Titans." (2014).
[86] Burgomaster, Kirsten A., Krista R. Howarth, Stuart M. Phillips, Mark Rakobowchuk, Maureen J. MacDonald, Sean L. McGee, and Martin J. Gibala. "Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans." The Journal of physiology 586, no. 1 (2008): 151-160.
[87] Hudlicka, Olga, and Margaret D. Brown. "Adaptation of skeletal muscle microvasculature to increased or decreased blood flow: role of shear stress, nitric oxide and vascular endothelial growth factor." Journal of vascular research 46, no. 5 (2009): 504-512.
[88] Koos, Brian J. "Adenosine A2a receptors and O2 sensing in development." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 301, no. 3 (2011): R601-R622.
[89] Ilkhanizadeh, Behrouz, Alireza Shirpoor, Samira Nemati, and Yusef Rasmi. "Protective effects of ginger (Zingiber officinale) extract against diabetes-induced heart abnormality in rats." Diabetes & metabolism journal 40, no. 1 (2016): 46-53.
[90] Ribatti, Domenico, and Enrico Crivellato. "Mast cells, angiogenesis, and tumour growth." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822, no. 1 (2012): 2-8.
[91] Milkiewicz, Malgorzata, M. D. Brown, Stuart Egginton, and Olga Hudlicka. "Association between shear stress, angiogenesis, and VEGF in skeletal muscles in vivo." Microcirculation 8, no. 4 (2001): 229-241.
[92] Hamzehzadeh Brojeni, E., P. Nazar Ali, and S. Naghibi. "The Effect of High Intensity Interval Training (HIIT) on aerobic and anaerobic some indicators of Iranian women's national teams of basketball players." Exercise Physiology 5, no. 4 (2012): 35-48.
[93] Kadoglou, N. P. E., I. S. Vrabas, N. Sailer, A. Kapelouzou, G. Fotiadis, G. Noussios, P. E. Karayannacos, and N. Angelopoulou. "Exercise ameliorates serum MMP-9 and TIMP-2 levels in patients with type 2 diabetes." Diabetes & metabolism 36, no. 2 (2010): 144-151.
[94] Nazari, Maryam, Mohammad Reza Kordi, and Siroos Choobineh. "The Effect of High Intensity Interval Training (HIIT) on Gelatinase-A (MMP-2) Serum Levels and Muscle Damage Indices in Young Sedentary Girls." Journal of Arak University of Medical Sciences 18, no. 1 (2015): 78-86.
[95] Folkman, Judah. "Fundamental concepts of the angiogenic process." Current molecular medicine 3, no. 7 (2003): 643-651.
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    Reza Sabzevari Rad. (2022). Effect of Exercise and Non-exercise Interventions on Cardiac Angiogenesis in Diabetes Mellitus Patients: A Review. International Journal of Diabetes and Endocrinology, 7(1), 1-12. https://doi.org/10.11648/j.ijde.20220701.11

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    Reza Sabzevari Rad. Effect of Exercise and Non-exercise Interventions on Cardiac Angiogenesis in Diabetes Mellitus Patients: A Review. Int. J. Diabetes Endocrinol. 2022, 7(1), 1-12. doi: 10.11648/j.ijde.20220701.11

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    AMA Style

    Reza Sabzevari Rad. Effect of Exercise and Non-exercise Interventions on Cardiac Angiogenesis in Diabetes Mellitus Patients: A Review. Int J Diabetes Endocrinol. 2022;7(1):1-12. doi: 10.11648/j.ijde.20220701.11

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  • @article{10.11648/j.ijde.20220701.11,
      author = {Reza Sabzevari Rad},
      title = {Effect of Exercise and Non-exercise Interventions on Cardiac Angiogenesis in Diabetes Mellitus Patients: A Review},
      journal = {International Journal of Diabetes and Endocrinology},
      volume = {7},
      number = {1},
      pages = {1-12},
      doi = {10.11648/j.ijde.20220701.11},
      url = {https://doi.org/10.11648/j.ijde.20220701.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220701.11},
      abstract = {Background: It has been shown that about 80% of deaths in diabetic patients are due to cardiovascular disorders, which are called Diabetic Heart Disease or DHD, the most important of which are dysfunction and vascular damage, and consequently the stopping of coronary angiogenesis. Despite the many advances made in the field of medical research and the long-standing clinical history of diabetes mellitus, the risk of cardiovascular disease associated with diabetes has not been reduced. Method: Our search was performed by typing the words HIIT, MICT, Diabetic Heart Disease, MicroRNA, Cardiac Angiogenesis in pubmed. We reviewed the literature using articles that were relevant to our field of work. conclusion: Researchers have proposed different exercise programs to improve cardiovascular complications in diabetic patient, and their prominent role in improving the complications associated with microangiopathy compared to non-exercise interventions (hormone, complementary therapies, pharmaceutical methods, etc.) in these proven patients. but so far no study has been done to compare the effectiveness of exercise or non-exercise interventions on the improvement of microvascular complications in DHD patients. Therefore, this review article compares the types of interventions that affect the angiogenesis of patients with a history of DHD.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Effect of Exercise and Non-exercise Interventions on Cardiac Angiogenesis in Diabetes Mellitus Patients: A Review
    AU  - Reza Sabzevari Rad
    Y1  - 2022/01/17
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijde.20220701.11
    DO  - 10.11648/j.ijde.20220701.11
    T2  - International Journal of Diabetes and Endocrinology
    JF  - International Journal of Diabetes and Endocrinology
    JO  - International Journal of Diabetes and Endocrinology
    SP  - 1
    EP  - 12
    PB  - Science Publishing Group
    SN  - 2640-1371
    UR  - https://doi.org/10.11648/j.ijde.20220701.11
    AB  - Background: It has been shown that about 80% of deaths in diabetic patients are due to cardiovascular disorders, which are called Diabetic Heart Disease or DHD, the most important of which are dysfunction and vascular damage, and consequently the stopping of coronary angiogenesis. Despite the many advances made in the field of medical research and the long-standing clinical history of diabetes mellitus, the risk of cardiovascular disease associated with diabetes has not been reduced. Method: Our search was performed by typing the words HIIT, MICT, Diabetic Heart Disease, MicroRNA, Cardiac Angiogenesis in pubmed. We reviewed the literature using articles that were relevant to our field of work. conclusion: Researchers have proposed different exercise programs to improve cardiovascular complications in diabetic patient, and their prominent role in improving the complications associated with microangiopathy compared to non-exercise interventions (hormone, complementary therapies, pharmaceutical methods, etc.) in these proven patients. but so far no study has been done to compare the effectiveness of exercise or non-exercise interventions on the improvement of microvascular complications in DHD patients. Therefore, this review article compares the types of interventions that affect the angiogenesis of patients with a history of DHD.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Department of Physical Education and Sports Sciences, Officer University of Imam Ali, Tehran, Iran

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