Changing Era of Diabetes Management – A New Perspective for Dapagliflozin

Manish Maladkar; Ashok Yadav; Shraddha Ghorui

doi:doi:10.11648/j.ijde.20220702.11

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Changing Era of Diabetes Management – A New Perspective for Dapagliflozin

Manish Maladkar, Ashok Yadav, Shraddha Ghorui

Published in International Journal of Diabetes and Endocrinology (Volume 7, Issue 2)

Received: 21 February 2022 Accepted: 26 March 2022 Published: 9 April 2022

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Abstract

Type 2 Diabetes Mellitus (T2DM) treatment has progressed dramatically in recent decades. The recent major expansion of the evidence base for T2DM treatment has resulted in frequent revisions of guidelines for hyperglycemia management. When there were few pharmaceutical options, the management strategy was glucocentric or hyperglycemic control. There has been a significant change from the glucocentric era to a more patient-centered and organ-protection era evident in clinical practice guidelines of diabetes management. In addition, since the diabetes armamentarium has grown and new information has been available, the focus has shifted from hyperglycemia control to a more holistic approach, including cardiovascular and renal benefits of the drugs and safety concerns such as weight gain, hypoglycemia. The introduction of the Sodium-Glucose Cotransporter 2 (SGLT2) inhibitor class of medications has had a substantial impact on diabetes management. The constant positive findings of multiple Cardiovascular Outcome Trials (CVOTs) with SGLT2 inhibitors prompted a paradigm shift: from hyperglycemia control to a patient-centered approach. As a result, SGLT2 inhibitors have been identified by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) as an ideal class for a more patient-centered approach to T2DM treatment, become a driving force in diabetes care. Dapagliflozin, an SGLT2 inhibitor, has recently emerged as a glucose-lowering medication that has been found to not only be successful in lowering glycemic levels but also to improve cardio-renal outcomes in diabetic patients. Furthermore, Dapagliflozin is the first anti-diabetic drug to show cardiac and renal benefits even in those who do not have diabetes. As a result, Dapagliflozin has paved the way for a future organ protection strategy for diabetes as well as non-diabetes.

Published in	International Journal of Diabetes and Endocrinology (Volume 7, Issue 2)
DOI	10.11648/j.ijde.20220702.11
Page(s)	22-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Dapagliflozin, Type 2 Diabetes, SGLT2 Inhibitors, DAPA-HF, DAPA-CKD, Heart Failure, CKD

References

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[14]	Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, et al. DECLARE–TIMI 58 Investigators. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019; 380 (4): 347-357. doi: 10.1056/NEJMoa1812389.
[15]	Garber AJ, Handelsman Y, Grunberger G, Einhorn D, Abrahamson MJ, Barzilay JI, et al. Consensus Statement By The American Association Of Clinical Endocrinologists And American College Of Endocrinology On The Comprehensive Type 2 Diabetes Management Algorithm - 2020 Executive Summary. Endocr Pract. 2020; 26 (1): 107-139. doi: 10.4158/CS-2019-0472.
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[23]	ClinicalTrials.gov. Dapagliflozin Effects on Cardiovascular Events in Patients With an Acute Heart Attack (DAPA-MI) Adapted from https://clinicaltrials.gov/ct2/show/NCT04564742 as accessed on 18 Feb 2022.
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APA Style

Manish Maladkar, Ashok Yadav, Shraddha Ghorui. (2022). Changing Era of Diabetes Management – A New Perspective for Dapagliflozin. International Journal of Diabetes and Endocrinology, 7(2), 22-28. https://doi.org/10.11648/j.ijde.20220702.11

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ACS Style

Manish Maladkar; Ashok Yadav; Shraddha Ghorui. Changing Era of Diabetes Management – A New Perspective for Dapagliflozin. Int. J. Diabetes Endocrinol. 2022, 7(2), 22-28. doi: 10.11648/j.ijde.20220702.11

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AMA Style

Manish Maladkar, Ashok Yadav, Shraddha Ghorui. Changing Era of Diabetes Management – A New Perspective for Dapagliflozin. Int J Diabetes Endocrinol. 2022;7(2):22-28. doi: 10.11648/j.ijde.20220702.11

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@article{10.11648/j.ijde.20220702.11,
  author = {Manish Maladkar and Ashok Yadav and Shraddha Ghorui},
  title = {Changing Era of Diabetes Management – A New Perspective for Dapagliflozin},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {7},
  number = {2},
  pages = {22-28},
  doi = {10.11648/j.ijde.20220702.11},
  url = {https://doi.org/10.11648/j.ijde.20220702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220702.11},
  abstract = {Type 2 Diabetes Mellitus (T2DM) treatment has progressed dramatically in recent decades. The recent major expansion of the evidence base for T2DM treatment has resulted in frequent revisions of guidelines for hyperglycemia management. When there were few pharmaceutical options, the management strategy was glucocentric or hyperglycemic control. There has been a significant change from the glucocentric era to a more patient-centered and organ-protection era evident in clinical practice guidelines of diabetes management. In addition, since the diabetes armamentarium has grown and new information has been available, the focus has shifted from hyperglycemia control to a more holistic approach, including cardiovascular and renal benefits of the drugs and safety concerns such as weight gain, hypoglycemia. The introduction of the Sodium-Glucose Cotransporter 2 (SGLT2) inhibitor class of medications has had a substantial impact on diabetes management. The constant positive findings of multiple Cardiovascular Outcome Trials (CVOTs) with SGLT2 inhibitors prompted a paradigm shift: from hyperglycemia control to a patient-centered approach. As a result, SGLT2 inhibitors have been identified by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) as an ideal class for a more patient-centered approach to T2DM treatment, become a driving force in diabetes care. Dapagliflozin, an SGLT2 inhibitor, has recently emerged as a glucose-lowering medication that has been found to not only be successful in lowering glycemic levels but also to improve cardio-renal outcomes in diabetic patients. Furthermore, Dapagliflozin is the first anti-diabetic drug to show cardiac and renal benefits even in those who do not have diabetes. As a result, Dapagliflozin has paved the way for a future organ protection strategy for diabetes as well as non-diabetes.},
 year = {2022}
}

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TY  - JOUR
T1  - Changing Era of Diabetes Management – A New Perspective for Dapagliflozin
AU  - Manish Maladkar
AU  - Ashok Yadav
AU  - Shraddha Ghorui
Y1  - 2022/04/09
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DO  - 10.11648/j.ijde.20220702.11
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JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
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AB  - Type 2 Diabetes Mellitus (T2DM) treatment has progressed dramatically in recent decades. The recent major expansion of the evidence base for T2DM treatment has resulted in frequent revisions of guidelines for hyperglycemia management. When there were few pharmaceutical options, the management strategy was glucocentric or hyperglycemic control. There has been a significant change from the glucocentric era to a more patient-centered and organ-protection era evident in clinical practice guidelines of diabetes management. In addition, since the diabetes armamentarium has grown and new information has been available, the focus has shifted from hyperglycemia control to a more holistic approach, including cardiovascular and renal benefits of the drugs and safety concerns such as weight gain, hypoglycemia. The introduction of the Sodium-Glucose Cotransporter 2 (SGLT2) inhibitor class of medications has had a substantial impact on diabetes management. The constant positive findings of multiple Cardiovascular Outcome Trials (CVOTs) with SGLT2 inhibitors prompted a paradigm shift: from hyperglycemia control to a patient-centered approach. As a result, SGLT2 inhibitors have been identified by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) as an ideal class for a more patient-centered approach to T2DM treatment, become a driving force in diabetes care. Dapagliflozin, an SGLT2 inhibitor, has recently emerged as a glucose-lowering medication that has been found to not only be successful in lowering glycemic levels but also to improve cardio-renal outcomes in diabetic patients. Furthermore, Dapagliflozin is the first anti-diabetic drug to show cardiac and renal benefits even in those who do not have diabetes. As a result, Dapagliflozin has paved the way for a future organ protection strategy for diabetes as well as non-diabetes.
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Author Information

Manish Maladkar

Scientific Department, Aristo Pharmaceuticals Private Ltd., Mumbai, India
Ashok Yadav

Scientific Department, Aristo Pharmaceuticals Private Ltd., Mumbai, India
Shraddha Ghorui

Scientific Department, Aristo Pharmaceuticals Private Ltd., Mumbai, India

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APA Style

Manish Maladkar, Ashok Yadav, Shraddha Ghorui. (2022). Changing Era of Diabetes Management – A New Perspective for Dapagliflozin. International Journal of Diabetes and Endocrinology, 7(2), 22-28. https://doi.org/10.11648/j.ijde.20220702.11

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ACS Style

Manish Maladkar; Ashok Yadav; Shraddha Ghorui. Changing Era of Diabetes Management – A New Perspective for Dapagliflozin. Int. J. Diabetes Endocrinol. 2022, 7(2), 22-28. doi: 10.11648/j.ijde.20220702.11

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AMA Style

Manish Maladkar, Ashok Yadav, Shraddha Ghorui. Changing Era of Diabetes Management – A New Perspective for Dapagliflozin. Int J Diabetes Endocrinol. 2022;7(2):22-28. doi: 10.11648/j.ijde.20220702.11

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@article{10.11648/j.ijde.20220702.11,
  author = {Manish Maladkar and Ashok Yadav and Shraddha Ghorui},
  title = {Changing Era of Diabetes Management – A New Perspective for Dapagliflozin},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {7},
  number = {2},
  pages = {22-28},
  doi = {10.11648/j.ijde.20220702.11},
  url = {https://doi.org/10.11648/j.ijde.20220702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220702.11},
  abstract = {Type 2 Diabetes Mellitus (T2DM) treatment has progressed dramatically in recent decades. The recent major expansion of the evidence base for T2DM treatment has resulted in frequent revisions of guidelines for hyperglycemia management. When there were few pharmaceutical options, the management strategy was glucocentric or hyperglycemic control. There has been a significant change from the glucocentric era to a more patient-centered and organ-protection era evident in clinical practice guidelines of diabetes management. In addition, since the diabetes armamentarium has grown and new information has been available, the focus has shifted from hyperglycemia control to a more holistic approach, including cardiovascular and renal benefits of the drugs and safety concerns such as weight gain, hypoglycemia. The introduction of the Sodium-Glucose Cotransporter 2 (SGLT2) inhibitor class of medications has had a substantial impact on diabetes management. The constant positive findings of multiple Cardiovascular Outcome Trials (CVOTs) with SGLT2 inhibitors prompted a paradigm shift: from hyperglycemia control to a patient-centered approach. As a result, SGLT2 inhibitors have been identified by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) as an ideal class for a more patient-centered approach to T2DM treatment, become a driving force in diabetes care. Dapagliflozin, an SGLT2 inhibitor, has recently emerged as a glucose-lowering medication that has been found to not only be successful in lowering glycemic levels but also to improve cardio-renal outcomes in diabetic patients. Furthermore, Dapagliflozin is the first anti-diabetic drug to show cardiac and renal benefits even in those who do not have diabetes. As a result, Dapagliflozin has paved the way for a future organ protection strategy for diabetes as well as non-diabetes.},
 year = {2022}
}

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TY  - JOUR
T1  - Changing Era of Diabetes Management – A New Perspective for Dapagliflozin
AU  - Manish Maladkar
AU  - Ashok Yadav
AU  - Shraddha Ghorui
Y1  - 2022/04/09
PY  - 2022
N1  - https://doi.org/10.11648/j.ijde.20220702.11
DO  - 10.11648/j.ijde.20220702.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 22
EP  - 28
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20220702.11
AB  - Type 2 Diabetes Mellitus (T2DM) treatment has progressed dramatically in recent decades. The recent major expansion of the evidence base for T2DM treatment has resulted in frequent revisions of guidelines for hyperglycemia management. When there were few pharmaceutical options, the management strategy was glucocentric or hyperglycemic control. There has been a significant change from the glucocentric era to a more patient-centered and organ-protection era evident in clinical practice guidelines of diabetes management. In addition, since the diabetes armamentarium has grown and new information has been available, the focus has shifted from hyperglycemia control to a more holistic approach, including cardiovascular and renal benefits of the drugs and safety concerns such as weight gain, hypoglycemia. The introduction of the Sodium-Glucose Cotransporter 2 (SGLT2) inhibitor class of medications has had a substantial impact on diabetes management. The constant positive findings of multiple Cardiovascular Outcome Trials (CVOTs) with SGLT2 inhibitors prompted a paradigm shift: from hyperglycemia control to a patient-centered approach. As a result, SGLT2 inhibitors have been identified by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) as an ideal class for a more patient-centered approach to T2DM treatment, become a driving force in diabetes care. Dapagliflozin, an SGLT2 inhibitor, has recently emerged as a glucose-lowering medication that has been found to not only be successful in lowering glycemic levels but also to improve cardio-renal outcomes in diabetic patients. Furthermore, Dapagliflozin is the first anti-diabetic drug to show cardiac and renal benefits even in those who do not have diabetes. As a result, Dapagliflozin has paved the way for a future organ protection strategy for diabetes as well as non-diabetes.
VL  - 7
IS  - 2
ER  -

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