The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan

Abdalwahab Ahmed Abdalla; Salman Taha Ahmed Elmukashfi; Ahmed Yasin Hassan; Ameer Dafalla; Khalid Abdelsamea

doi:doi:10.11648/j.ijde.20230801.11

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The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan

Abdalwahab Ahmed Abdalla, Salman Taha Ahmed Elmukashfi, Ahmed Yasin Hassan, Ameer Dafalla, Khalid Abdelsamea

Published in International Journal of Diabetes and Endocrinology (Volume 8, Issue 1)

Received: 4 October 2022 Accepted: 26 October 2022 Published: 9 January 2023

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Abstract

Background and Objective: Diabetes is one of the most common diseases in the world, and its prevalence has increased dramatically in the last century until it reached approximately 422 million in the world. The increase in disease has lead to a decrease in production and an increase in financial costs for patients, several methods were taken to diagnose diabetes millets such as glucose tolerance and fasting glucose measurement until the Ministry of World Health approved in 2011 that hemoglobin A1c is suitable for diagnosing and controlling diabetes. But some studies indicated Hemoglobin A1c is affected by aspirin and other factors that can give false results and affect diagnosis or monitoring. So this Cross-Sectional study was conducted and the aim to study the effect of aspirin on hemoglobin A1c among diabetic hypertensive, to determine the effect of aspirin, age, sex and fasting glucose on HbA1c concentration. Materials and Methods: ichroma was used for measuring HbA1c and colorimeter for measuring fasting blood glucose. Questionnaire for age and sex, the venous sample were collected in (EDTA) Ethlyine Di amin tetra acetic acid for HbA1c measuring and fluoride oxalate for fasting measuring. The study was done at Wad Madni and included 100 patients with diabetes and hypertension, 50 of them used aspirin, while the other 50 did not use aspirin. Results: The result of the study was increased in HbA1c in patient use aspirin more than 2 years HbA1c mean was (9.7) and less in patient use aspirin less than 2 years HbA1c mean (9.4), p value (0.048). The comparison between male and female the HbA1c was more in female (10.6) than male (9.2), p value (0.045) also HbA1c associated with BMI and fasting glucose. The statistically package for social studies (SPSS) version 20 programs was used for the analysis of data. Relative risk and odd ratio also should be calculated was used for statistical analysis. Conclusion: The level of HbA1c is increase with aspirin using and associated with fasting blood glucose and BMI. And female have high level of HbA1c than male. The age of patient not effect on HbA1c level.

Published in	International Journal of Diabetes and Endocrinology (Volume 8, Issue 1)
DOI	10.11648/j.ijde.20230801.11
Page(s)	1-5
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetes Mellitus, Hypertension, HbA1c, Fasting Glucose, Aspirin

References

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[2]	Chris, F., (2016) Aspirin resistance associated with HbA1c and obesity in diabetic patients journal of BiomarkerInsights volume (18) pp 317 -320.
[3]	Nicola, V and Jacopo, D., (2008) Review of hemoglobin A1c in the management of diabetes. Clinical pharmacology volum 86 issue 8 pp 19-21.
[4]	Unnikrishnan, R., Anjana, R. M., & Mohan, V. (2012). Drugs affecting HbA1c levels. Indian journal of endocrinology and metabolism, 16 (4), 528–531.
[5]	Randier, A., Jack. D., David. E., (2001). measure micro vascular risk complications by HbA1c blood glucose Diabetes care journal, vol. 50, pp 88-93.
[6]	Wheele, E., (2018) Genetics of HbA1c: a case study in clinical translation current opinion in genetic and development pp 79-85.
[7]	Lin, H., & Yi, J., (2017). Current Status of HbA1c Biosensors. Sensors (Basel, Switzerland), 17 (8), 1798.
[8]	World Health Organization (2011), Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus: Abbreviated Report of a WHO Consultation. Geneva, Glycated haemoglobin (HbA1c) for the diagnosis of diabetes.
[9]	Cavagnolli, G., Pimentel, A. L., Freitas, P. A., Gross, J. L., & Camargo, J. L., (2017). Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis. Journal of PloS one, 12 (2), e0171315.
[10]	Sherwani SI, Khan HA, and Ekhzaimy A, et al., (2016). Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients. Biomark Insights (11): pp 95-104.
[11]	Camargo JL, Stifft J, Gross JL., (2006). The effect of aspirin and vitamins C and E on HbA1c assays. Clinica Chimica Acta; International Journal of Clinical Chemistry. 372 (1-2): pp 206-209.
[12]	Francesco, F., Feliciano, P., and Nolli, P., et al (2015) aspirin mediated acetylation of haemoglobin increase in presens of high glucose concentration and dcrease protein glycation open jornal EupA proteomic volume (8): pp 116-127.
[13]	Dubowitz N., Xue w, and long Q, et al, (2014) Ageing is associated with increase Hba1c level independently of glucose level and insulin resistance and also with decrease HbA1c diagnostic specify. diabetes Med. (8) pp 927-35.
[14]	TomokoN, junko o, Tadasu k., (2017) effect hemoglobin and sex on hba1c level among Japaneese population. diabetes and endocrinology ISSN: 2639-8176.
[15]	Qinglin Ma, Houming Liu, and Xiang, G, et al., (2017) assassination between glycated hemoglobin A1c level with age and gender in Chinese adult with no prior diagnosis of diabetes mellitus journal of biomedical report pp 73-75.
[16]	Zahra GH, Ali A, Haghdoost MD, and Farzaneh z., (2010) a comparison of HbA1cand fasting blood sugar test in general population international journal of preventive medicine 1 (13): p 187-194.

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Abdalwahab Ahmed Abdalla, Salman Taha Ahmed Elmukashfi, Ahmed Yasin Hassan, Ameer Dafalla, Khalid Abdelsamea. (2023). The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan. International Journal of Diabetes and Endocrinology, 8(1), 1-5. https://doi.org/10.11648/j.ijde.20230801.11

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ACS Style

Abdalwahab Ahmed Abdalla; Salman Taha Ahmed Elmukashfi; Ahmed Yasin Hassan; Ameer Dafalla; Khalid Abdelsamea. The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan. Int. J. Diabetes Endocrinol. 2023, 8(1), 1-5. doi: 10.11648/j.ijde.20230801.11

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AMA Style

Abdalwahab Ahmed Abdalla, Salman Taha Ahmed Elmukashfi, Ahmed Yasin Hassan, Ameer Dafalla, Khalid Abdelsamea. The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan. Int J Diabetes Endocrinol. 2023;8(1):1-5. doi: 10.11648/j.ijde.20230801.11

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@article{10.11648/j.ijde.20230801.11,
  author = {Abdalwahab Ahmed Abdalla and Salman Taha Ahmed Elmukashfi and Ahmed Yasin Hassan and Ameer Dafalla and Khalid Abdelsamea},
  title = {The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {8},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ijde.20230801.11},
  url = {https://doi.org/10.11648/j.ijde.20230801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20230801.11},
  abstract = {Background and Objective: Diabetes is one of the most common diseases in the world, and its prevalence has increased dramatically in the last century until it reached approximately 422 million in the world. The increase in disease has lead to a decrease in production and an increase in financial costs for patients, several methods were taken to diagnose diabetes millets such as glucose tolerance and fasting glucose measurement until the Ministry of World Health approved in 2011 that hemoglobin A1c is suitable for diagnosing and controlling diabetes. But some studies indicated Hemoglobin A1c is affected by aspirin and other factors that can give false results and affect diagnosis or monitoring. So this Cross-Sectional study was conducted and the aim to study the effect of aspirin on hemoglobin A1c among diabetic hypertensive, to determine the effect of aspirin, age, sex and fasting glucose on HbA1c concentration. Materials and Methods: ichroma was used for measuring HbA1c and colorimeter for measuring fasting blood glucose. Questionnaire for age and sex, the venous sample were collected in (EDTA) Ethlyine Di amin tetra acetic acid for HbA1c measuring and fluoride oxalate for fasting measuring. The study was done at Wad Madni and included 100 patients with diabetes and hypertension, 50 of them used aspirin, while the other 50 did not use aspirin. Results: The result of the study was increased in HbA1c in patient use aspirin more than 2 years HbA1c mean was (9.7) and less in patient use aspirin less than 2 years HbA1c mean (9.4), p value (0.048). The comparison between male and female the HbA1c was more in female (10.6) than male (9.2), p value (0.045) also HbA1c associated with BMI and fasting glucose. The statistically package for social studies (SPSS) version 20 programs was used for the analysis of data. Relative risk and odd ratio also should be calculated was used for statistical analysis. Conclusion: The level of HbA1c is increase with aspirin using and associated with fasting blood glucose and BMI. And female have high level of HbA1c than male. The age of patient not effect on HbA1c level.},
 year = {2023}
}

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TY  - JOUR
T1  - The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan
AU  - Abdalwahab Ahmed Abdalla
AU  - Salman Taha Ahmed Elmukashfi
AU  - Ahmed Yasin Hassan
AU  - Ameer Dafalla
AU  - Khalid Abdelsamea
Y1  - 2023/01/09
PY  - 2023
N1  - https://doi.org/10.11648/j.ijde.20230801.11
DO  - 10.11648/j.ijde.20230801.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20230801.11
AB  - Background and Objective: Diabetes is one of the most common diseases in the world, and its prevalence has increased dramatically in the last century until it reached approximately 422 million in the world. The increase in disease has lead to a decrease in production and an increase in financial costs for patients, several methods were taken to diagnose diabetes millets such as glucose tolerance and fasting glucose measurement until the Ministry of World Health approved in 2011 that hemoglobin A1c is suitable for diagnosing and controlling diabetes. But some studies indicated Hemoglobin A1c is affected by aspirin and other factors that can give false results and affect diagnosis or monitoring. So this Cross-Sectional study was conducted and the aim to study the effect of aspirin on hemoglobin A1c among diabetic hypertensive, to determine the effect of aspirin, age, sex and fasting glucose on HbA1c concentration. Materials and Methods: ichroma was used for measuring HbA1c and colorimeter for measuring fasting blood glucose. Questionnaire for age and sex, the venous sample were collected in (EDTA) Ethlyine Di amin tetra acetic acid for HbA1c measuring and fluoride oxalate for fasting measuring. The study was done at Wad Madni and included 100 patients with diabetes and hypertension, 50 of them used aspirin, while the other 50 did not use aspirin. Results: The result of the study was increased in HbA1c in patient use aspirin more than 2 years HbA1c mean was (9.7) and less in patient use aspirin less than 2 years HbA1c mean (9.4), p value (0.048). The comparison between male and female the HbA1c was more in female (10.6) than male (9.2), p value (0.045) also HbA1c associated with BMI and fasting glucose. The statistically package for social studies (SPSS) version 20 programs was used for the analysis of data. Relative risk and odd ratio also should be calculated was used for statistical analysis. Conclusion: The level of HbA1c is increase with aspirin using and associated with fasting blood glucose and BMI. And female have high level of HbA1c than male. The age of patient not effect on HbA1c level.
VL  - 8
IS  - 1
ER  -

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Author Information

Abdalwahab Ahmed Abdalla

Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Madani, Sudan
Salman Taha Ahmed Elmukashfi

Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Dongola, Al Dabbah, Sudan
Ahmed Yasin Hassan

Laboratory and Blood Bank Department, Ibrahim Malik Teaching Hospital, Khartoum, Sudan
Ameer Dafalla

Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Madani, Sudan
Khalid Abdelsamea

Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Madani, Sudan

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APA Style

Abdalwahab Ahmed Abdalla, Salman Taha Ahmed Elmukashfi, Ahmed Yasin Hassan, Ameer Dafalla, Khalid Abdelsamea. (2023). The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan. International Journal of Diabetes and Endocrinology, 8(1), 1-5. https://doi.org/10.11648/j.ijde.20230801.11

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ACS Style

Abdalwahab Ahmed Abdalla; Salman Taha Ahmed Elmukashfi; Ahmed Yasin Hassan; Ameer Dafalla; Khalid Abdelsamea. The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan. Int. J. Diabetes Endocrinol. 2023, 8(1), 1-5. doi: 10.11648/j.ijde.20230801.11

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AMA Style

Abdalwahab Ahmed Abdalla, Salman Taha Ahmed Elmukashfi, Ahmed Yasin Hassan, Ameer Dafalla, Khalid Abdelsamea. The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan. Int J Diabetes Endocrinol. 2023;8(1):1-5. doi: 10.11648/j.ijde.20230801.11

Copy | Download

@article{10.11648/j.ijde.20230801.11,
  author = {Abdalwahab Ahmed Abdalla and Salman Taha Ahmed Elmukashfi and Ahmed Yasin Hassan and Ameer Dafalla and Khalid Abdelsamea},
  title = {The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {8},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ijde.20230801.11},
  url = {https://doi.org/10.11648/j.ijde.20230801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20230801.11},
  abstract = {Background and Objective: Diabetes is one of the most common diseases in the world, and its prevalence has increased dramatically in the last century until it reached approximately 422 million in the world. The increase in disease has lead to a decrease in production and an increase in financial costs for patients, several methods were taken to diagnose diabetes millets such as glucose tolerance and fasting glucose measurement until the Ministry of World Health approved in 2011 that hemoglobin A1c is suitable for diagnosing and controlling diabetes. But some studies indicated Hemoglobin A1c is affected by aspirin and other factors that can give false results and affect diagnosis or monitoring. So this Cross-Sectional study was conducted and the aim to study the effect of aspirin on hemoglobin A1c among diabetic hypertensive, to determine the effect of aspirin, age, sex and fasting glucose on HbA1c concentration. Materials and Methods: ichroma was used for measuring HbA1c and colorimeter for measuring fasting blood glucose. Questionnaire for age and sex, the venous sample were collected in (EDTA) Ethlyine Di amin tetra acetic acid for HbA1c measuring and fluoride oxalate for fasting measuring. The study was done at Wad Madni and included 100 patients with diabetes and hypertension, 50 of them used aspirin, while the other 50 did not use aspirin. Results: The result of the study was increased in HbA1c in patient use aspirin more than 2 years HbA1c mean was (9.7) and less in patient use aspirin less than 2 years HbA1c mean (9.4), p value (0.048). The comparison between male and female the HbA1c was more in female (10.6) than male (9.2), p value (0.045) also HbA1c associated with BMI and fasting glucose. The statistically package for social studies (SPSS) version 20 programs was used for the analysis of data. Relative risk and odd ratio also should be calculated was used for statistical analysis. Conclusion: The level of HbA1c is increase with aspirin using and associated with fasting blood glucose and BMI. And female have high level of HbA1c than male. The age of patient not effect on HbA1c level.},
 year = {2023}
}

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TY  - JOUR
T1  - The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan
AU  - Abdalwahab Ahmed Abdalla
AU  - Salman Taha Ahmed Elmukashfi
AU  - Ahmed Yasin Hassan
AU  - Ameer Dafalla
AU  - Khalid Abdelsamea
Y1  - 2023/01/09
PY  - 2023
N1  - https://doi.org/10.11648/j.ijde.20230801.11
DO  - 10.11648/j.ijde.20230801.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20230801.11
AB  - Background and Objective: Diabetes is one of the most common diseases in the world, and its prevalence has increased dramatically in the last century until it reached approximately 422 million in the world. The increase in disease has lead to a decrease in production and an increase in financial costs for patients, several methods were taken to diagnose diabetes millets such as glucose tolerance and fasting glucose measurement until the Ministry of World Health approved in 2011 that hemoglobin A1c is suitable for diagnosing and controlling diabetes. But some studies indicated Hemoglobin A1c is affected by aspirin and other factors that can give false results and affect diagnosis or monitoring. So this Cross-Sectional study was conducted and the aim to study the effect of aspirin on hemoglobin A1c among diabetic hypertensive, to determine the effect of aspirin, age, sex and fasting glucose on HbA1c concentration. Materials and Methods: ichroma was used for measuring HbA1c and colorimeter for measuring fasting blood glucose. Questionnaire for age and sex, the venous sample were collected in (EDTA) Ethlyine Di amin tetra acetic acid for HbA1c measuring and fluoride oxalate for fasting measuring. The study was done at Wad Madni and included 100 patients with diabetes and hypertension, 50 of them used aspirin, while the other 50 did not use aspirin. Results: The result of the study was increased in HbA1c in patient use aspirin more than 2 years HbA1c mean was (9.7) and less in patient use aspirin less than 2 years HbA1c mean (9.4), p value (0.048). The comparison between male and female the HbA1c was more in female (10.6) than male (9.2), p value (0.045) also HbA1c associated with BMI and fasting glucose. The statistically package for social studies (SPSS) version 20 programs was used for the analysis of data. Relative risk and odd ratio also should be calculated was used for statistical analysis. Conclusion: The level of HbA1c is increase with aspirin using and associated with fasting blood glucose and BMI. And female have high level of HbA1c than male. The age of patient not effect on HbA1c level.
VL  - 8
IS  - 1
ER  -

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