Liver Involvement in Leptospirosis

Galya Ivanova Gancheva

doi:doi:10.11648/j.ijidt.20160101.12

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Liver Involvement in Leptospirosis

Galya Ivanova Gancheva

Published in International Journal of Infectious Diseases and Therapy (Volume 1, Issue 1)

Received: 30 October 2016 Accepted: 17 November 2016 Published: 21 December 2016

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Abstract

Liver involvement is a common feature of leptospirosis. It is variable from mild to severe hepatic dysfunction. Objective: to analyze liver involvement and to assess its prognostic value in leptospirosis. Materials and methods: We performed analysis of 100 consecutive leptospirosis cases treated in Clinic of Infectious Diseases at University Hospital – Pleven (1976-2015)(90 male, mean age 37±18 years, lethal outcome in 13%), followed by comparative analysis of group with liver involvement (n₁=71) versus group without liver involvement (n₂=29). Results: Fever (100%), hepatomegaly (92%), myalgia (86%), vomiting (84%), splenomegaly (74%), oliguria (69%), jaundice (63%), hypotension (49%), abdominal pain (41%), and hemorrhagic diathesis (37%) were the characteristic manifestations. Headache, myalgia, abdominal pain, oliguria, hemorrhagic diathesis, myocarditis, acute respiratory failure and pancreatitis had had a significantly higher prevalence in the group with liver involvement. Increased levels of total bilirubin (mean 157.8±71.5 µmol/L) with prevalent direct fraction, ASAT (mean 112±18 IU/L), ALAT (mean 96±78 IU/L), hypoproteinemia and hypoalbuminemia were the main laboratory parameters that expressed hepatic dysfunction. Conclusion: The most affected liver functions are bilirubin metabolism and protein synthesis. Liver involvement in leptospirosis is important factor for severity, in combination with acute renal failure has severe course and requires early diagnosis and prompt intensive treatment.

Published in	International Journal of Infectious Diseases and Therapy (Volume 1, Issue 1)
DOI	10.11648/j.ijidt.20160101.12
Page(s)	6-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Acute Renal Failure, Hepatic Dysfunction, Leptospirosis, Liver Involvement

References

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APA Style

Galya Ivanova Gancheva. (2016). Liver Involvement in Leptospirosis. International Journal of Infectious Diseases and Therapy, 1(1), 6-12. https://doi.org/10.11648/j.ijidt.20160101.12

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Galya Ivanova Gancheva. Liver Involvement in Leptospirosis. Int. J. Infect. Dis. Ther. 2016, 1(1), 6-12. doi: 10.11648/j.ijidt.20160101.12

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AMA Style

Galya Ivanova Gancheva. Liver Involvement in Leptospirosis. Int J Infect Dis Ther. 2016;1(1):6-12. doi: 10.11648/j.ijidt.20160101.12

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@article{10.11648/j.ijidt.20160101.12,
  author = {Galya Ivanova Gancheva},
  title = {Liver Involvement in Leptospirosis},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {1},
  number = {1},
  pages = {6-12},
  doi = {10.11648/j.ijidt.20160101.12},
  url = {https://doi.org/10.11648/j.ijidt.20160101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20160101.12},
  abstract = {Liver involvement is a common feature of leptospirosis. It is variable from mild to severe hepatic dysfunction. Objective: to analyze liver involvement and to assess its prognostic value in leptospirosis. Materials and methods: We performed analysis of 100 consecutive leptospirosis cases treated in Clinic of Infectious Diseases at University Hospital – Pleven (1976-2015)(90 male, mean age 37±18 years, lethal outcome in 13%), followed by comparative analysis of group with liver involvement (n1=71) versus group without liver involvement (n2=29). Results: Fever (100%), hepatomegaly (92%), myalgia (86%), vomiting (84%), splenomegaly (74%), oliguria (69%), jaundice (63%), hypotension (49%), abdominal pain (41%), and hemorrhagic diathesis (37%) were the characteristic manifestations. Headache, myalgia, abdominal pain, oliguria, hemorrhagic diathesis, myocarditis, acute respiratory failure and pancreatitis had had a significantly higher prevalence in the group with liver involvement. Increased levels of total bilirubin (mean 157.8±71.5 µmol/L) with prevalent direct fraction, ASAT (mean 112±18 IU/L), ALAT (mean 96±78 IU/L), hypoproteinemia and hypoalbuminemia were the main laboratory parameters that expressed hepatic dysfunction. Conclusion: The most affected liver functions are bilirubin metabolism and protein synthesis. Liver involvement in leptospirosis is important factor for severity, in combination with acute renal failure has severe course and requires early diagnosis and prompt intensive treatment.},
 year = {2016}
}

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TY  - JOUR
T1  - Liver Involvement in Leptospirosis
AU  - Galya Ivanova Gancheva
Y1  - 2016/12/21
PY  - 2016
N1  - https://doi.org/10.11648/j.ijidt.20160101.12
DO  - 10.11648/j.ijidt.20160101.12
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 6
EP  - 12
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20160101.12
AB  - Liver involvement is a common feature of leptospirosis. It is variable from mild to severe hepatic dysfunction. Objective: to analyze liver involvement and to assess its prognostic value in leptospirosis. Materials and methods: We performed analysis of 100 consecutive leptospirosis cases treated in Clinic of Infectious Diseases at University Hospital – Pleven (1976-2015)(90 male, mean age 37±18 years, lethal outcome in 13%), followed by comparative analysis of group with liver involvement (n1=71) versus group without liver involvement (n2=29). Results: Fever (100%), hepatomegaly (92%), myalgia (86%), vomiting (84%), splenomegaly (74%), oliguria (69%), jaundice (63%), hypotension (49%), abdominal pain (41%), and hemorrhagic diathesis (37%) were the characteristic manifestations. Headache, myalgia, abdominal pain, oliguria, hemorrhagic diathesis, myocarditis, acute respiratory failure and pancreatitis had had a significantly higher prevalence in the group with liver involvement. Increased levels of total bilirubin (mean 157.8±71.5 µmol/L) with prevalent direct fraction, ASAT (mean 112±18 IU/L), ALAT (mean 96±78 IU/L), hypoproteinemia and hypoalbuminemia were the main laboratory parameters that expressed hepatic dysfunction. Conclusion: The most affected liver functions are bilirubin metabolism and protein synthesis. Liver involvement in leptospirosis is important factor for severity, in combination with acute renal failure has severe course and requires early diagnosis and prompt intensive treatment.
VL  - 1
IS  - 1
ER  -

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Author Information

Galya Ivanova Gancheva

Department of Infectious Diseases, Epidemiology, Parasitology and Tropical Medicine, Medical University-Pleven, Bulgaria

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APA Style

Galya Ivanova Gancheva. (2016). Liver Involvement in Leptospirosis. International Journal of Infectious Diseases and Therapy, 1(1), 6-12. https://doi.org/10.11648/j.ijidt.20160101.12

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Galya Ivanova Gancheva. Liver Involvement in Leptospirosis. Int. J. Infect. Dis. Ther. 2016, 1(1), 6-12. doi: 10.11648/j.ijidt.20160101.12

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AMA Style

Galya Ivanova Gancheva. Liver Involvement in Leptospirosis. Int J Infect Dis Ther. 2016;1(1):6-12. doi: 10.11648/j.ijidt.20160101.12

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@article{10.11648/j.ijidt.20160101.12,
  author = {Galya Ivanova Gancheva},
  title = {Liver Involvement in Leptospirosis},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {1},
  number = {1},
  pages = {6-12},
  doi = {10.11648/j.ijidt.20160101.12},
  url = {https://doi.org/10.11648/j.ijidt.20160101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20160101.12},
  abstract = {Liver involvement is a common feature of leptospirosis. It is variable from mild to severe hepatic dysfunction. Objective: to analyze liver involvement and to assess its prognostic value in leptospirosis. Materials and methods: We performed analysis of 100 consecutive leptospirosis cases treated in Clinic of Infectious Diseases at University Hospital – Pleven (1976-2015)(90 male, mean age 37±18 years, lethal outcome in 13%), followed by comparative analysis of group with liver involvement (n1=71) versus group without liver involvement (n2=29). Results: Fever (100%), hepatomegaly (92%), myalgia (86%), vomiting (84%), splenomegaly (74%), oliguria (69%), jaundice (63%), hypotension (49%), abdominal pain (41%), and hemorrhagic diathesis (37%) were the characteristic manifestations. Headache, myalgia, abdominal pain, oliguria, hemorrhagic diathesis, myocarditis, acute respiratory failure and pancreatitis had had a significantly higher prevalence in the group with liver involvement. Increased levels of total bilirubin (mean 157.8±71.5 µmol/L) with prevalent direct fraction, ASAT (mean 112±18 IU/L), ALAT (mean 96±78 IU/L), hypoproteinemia and hypoalbuminemia were the main laboratory parameters that expressed hepatic dysfunction. Conclusion: The most affected liver functions are bilirubin metabolism and protein synthesis. Liver involvement in leptospirosis is important factor for severity, in combination with acute renal failure has severe course and requires early diagnosis and prompt intensive treatment.},
 year = {2016}
}

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TY  - JOUR
T1  - Liver Involvement in Leptospirosis
AU  - Galya Ivanova Gancheva
Y1  - 2016/12/21
PY  - 2016
N1  - https://doi.org/10.11648/j.ijidt.20160101.12
DO  - 10.11648/j.ijidt.20160101.12
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 6
EP  - 12
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20160101.12
AB  - Liver involvement is a common feature of leptospirosis. It is variable from mild to severe hepatic dysfunction. Objective: to analyze liver involvement and to assess its prognostic value in leptospirosis. Materials and methods: We performed analysis of 100 consecutive leptospirosis cases treated in Clinic of Infectious Diseases at University Hospital – Pleven (1976-2015)(90 male, mean age 37±18 years, lethal outcome in 13%), followed by comparative analysis of group with liver involvement (n1=71) versus group without liver involvement (n2=29). Results: Fever (100%), hepatomegaly (92%), myalgia (86%), vomiting (84%), splenomegaly (74%), oliguria (69%), jaundice (63%), hypotension (49%), abdominal pain (41%), and hemorrhagic diathesis (37%) were the characteristic manifestations. Headache, myalgia, abdominal pain, oliguria, hemorrhagic diathesis, myocarditis, acute respiratory failure and pancreatitis had had a significantly higher prevalence in the group with liver involvement. Increased levels of total bilirubin (mean 157.8±71.5 µmol/L) with prevalent direct fraction, ASAT (mean 112±18 IU/L), ALAT (mean 96±78 IU/L), hypoproteinemia and hypoalbuminemia were the main laboratory parameters that expressed hepatic dysfunction. Conclusion: The most affected liver functions are bilirubin metabolism and protein synthesis. Liver involvement in leptospirosis is important factor for severity, in combination with acute renal failure has severe course and requires early diagnosis and prompt intensive treatment.
VL  - 1
IS  - 1
ER  -

Copy | Download