Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review

Mulatu Workie Desta; Betemariam Kebede Gebremicheal

doi:doi:10.11648/j.ijmb.20200503.11

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Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review

Mulatu Workie Desta, Betemariam Kebede Gebremicheal

Published in International Journal of Microbiology and Biotechnology (Volume 5, Issue 3)

Received: 17 December 2019 Accepted: 19 May 2020 Published: 8 June 2020

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Abstract

Turmeric (from Curcuma longa) is a yellow colored spice commonly used in daily diet. It has been extensively used in traditional medicine since ancient times to treat various nervous and disorder disease. A little was known about the biosynthesis curcuminoid in turmeric and identified the enzymes involved in the curcuminoid biosynthetic pathway and confirmed the involvement of the phenylpropanoid pathway in the production of these compounds in plants. Traditionally known curcumin has emerged as a modern biological regulator curcuminoids, agroclimatic and soil environmental variation are also influencing the curcumin synthase gene expression, which is correlated with curcumin yield in turmeric cultivars. Microbial production of curcuminoids is very promising and production yield can be improved by using synthetic biology approaches and metabolic engineering tools, to make heterologous production competitive with the current process of curcuminoid’s extraction from plants. Type III polyketide synthases are responsible for the production of curcuminoids. Among those DCS and CURS enzymes have been used to synthesize curcuminoids. Synthetic biology and metabolite engineering approaches have generated microbial cell factories that can allow the for the mass production of pharmaceutically and nutraceuticals important microbial metabolites in an environmentally friendly and efficient way. Considering a wide pharmaceutical, industrial and health beneficial applications of curcuminoids, this review focused on microbial production of curcuminoids and substrate recognizing and regulatory mechanism of curcuminoid synthase and obtain the mutant enzymes using mutagenesis study and synthetic biology approaches.

Published in	International Journal of Microbiology and Biotechnology (Volume 5, Issue 3)
DOI	10.11648/j.ijmb.20200503.11
Page(s)	74-82
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Curcuminoids, Curcuma Longa, Polyketides, Turmeric

References

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Mulatu Workie Desta, Betemariam Kebede Gebremicheal. (2020). Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review. International Journal of Microbiology and Biotechnology, 5(3), 74-82. https://doi.org/10.11648/j.ijmb.20200503.11

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ACS Style

Mulatu Workie Desta; Betemariam Kebede Gebremicheal. Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review. Int. J. Microbiol. Biotechnol. 2020, 5(3), 74-82. doi: 10.11648/j.ijmb.20200503.11

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AMA Style

Mulatu Workie Desta, Betemariam Kebede Gebremicheal. Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review. Int J Microbiol Biotechnol. 2020;5(3):74-82. doi: 10.11648/j.ijmb.20200503.11

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@article{10.11648/j.ijmb.20200503.11,
  author = {Mulatu Workie Desta and Betemariam Kebede Gebremicheal},
  title = {Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review},
  journal = {International Journal of Microbiology and Biotechnology},
  volume = {5},
  number = {3},
  pages = {74-82},
  doi = {10.11648/j.ijmb.20200503.11},
  url = {https://doi.org/10.11648/j.ijmb.20200503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmb.20200503.11},
  abstract = {Turmeric (from Curcuma longa) is a yellow colored spice commonly used in daily diet. It has been extensively used in traditional medicine since ancient times to treat various nervous and disorder disease. A little was known about the biosynthesis curcuminoid in turmeric and identified the enzymes involved in the curcuminoid biosynthetic pathway and confirmed the involvement of the phenylpropanoid pathway in the production of these compounds in plants. Traditionally known curcumin has emerged as a modern biological regulator curcuminoids, agroclimatic and soil environmental variation are also influencing the curcumin synthase gene expression, which is correlated with curcumin yield in turmeric cultivars. Microbial production of curcuminoids is very promising and production yield can be improved by using synthetic biology approaches and metabolic engineering tools, to make heterologous production competitive with the current process of curcuminoid’s extraction from plants. Type III polyketide synthases are responsible for the production of curcuminoids. Among those DCS and CURS enzymes have been used to synthesize curcuminoids. Synthetic biology and metabolite engineering approaches have generated microbial cell factories that can allow the for the mass production of pharmaceutically and nutraceuticals important microbial metabolites in an environmentally friendly and efficient way. Considering a wide pharmaceutical, industrial and health beneficial applications of curcuminoids, this review focused on microbial production of curcuminoids and substrate recognizing and regulatory mechanism of curcuminoid synthase and obtain the mutant enzymes using mutagenesis study and synthetic biology approaches.},
 year = {2020}
}

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TY  - JOUR
T1  - Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review
AU  - Mulatu Workie Desta
AU  - Betemariam Kebede Gebremicheal
Y1  - 2020/06/08
PY  - 2020
N1  - https://doi.org/10.11648/j.ijmb.20200503.11
DO  - 10.11648/j.ijmb.20200503.11
T2  - International Journal of Microbiology and Biotechnology
JF  - International Journal of Microbiology and Biotechnology
JO  - International Journal of Microbiology and Biotechnology
SP  - 74
EP  - 82
PB  - Science Publishing Group
SN  - 2578-9686
UR  - https://doi.org/10.11648/j.ijmb.20200503.11
AB  - Turmeric (from Curcuma longa) is a yellow colored spice commonly used in daily diet. It has been extensively used in traditional medicine since ancient times to treat various nervous and disorder disease. A little was known about the biosynthesis curcuminoid in turmeric and identified the enzymes involved in the curcuminoid biosynthetic pathway and confirmed the involvement of the phenylpropanoid pathway in the production of these compounds in plants. Traditionally known curcumin has emerged as a modern biological regulator curcuminoids, agroclimatic and soil environmental variation are also influencing the curcumin synthase gene expression, which is correlated with curcumin yield in turmeric cultivars. Microbial production of curcuminoids is very promising and production yield can be improved by using synthetic biology approaches and metabolic engineering tools, to make heterologous production competitive with the current process of curcuminoid’s extraction from plants. Type III polyketide synthases are responsible for the production of curcuminoids. Among those DCS and CURS enzymes have been used to synthesize curcuminoids. Synthetic biology and metabolite engineering approaches have generated microbial cell factories that can allow the for the mass production of pharmaceutically and nutraceuticals important microbial metabolites in an environmentally friendly and efficient way. Considering a wide pharmaceutical, industrial and health beneficial applications of curcuminoids, this review focused on microbial production of curcuminoids and substrate recognizing and regulatory mechanism of curcuminoid synthase and obtain the mutant enzymes using mutagenesis study and synthetic biology approaches.
VL  - 5
IS  - 3
ER  -

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Author Information

Mulatu Workie Desta

Ethiopian Institute of Agricultural Research (EIAR), National Agricultural Biotechnology Research Centre (NABRC), Microbial Biotechnology Research Laboratory, Holetta, Ethiopia
Betemariam Kebede Gebremicheal

Ethiopian Institute of Agricultural Research (EIAR), National Agricultural Biotechnology Research Centre (NABRC), Microbial Biotechnology Research Laboratory, Holetta, Ethiopia

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Mulatu Workie Desta, Betemariam Kebede Gebremicheal. (2020). Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review. International Journal of Microbiology and Biotechnology, 5(3), 74-82. https://doi.org/10.11648/j.ijmb.20200503.11

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ACS Style

Mulatu Workie Desta; Betemariam Kebede Gebremicheal. Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review. Int. J. Microbiol. Biotechnol. 2020, 5(3), 74-82. doi: 10.11648/j.ijmb.20200503.11

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AMA Style

Mulatu Workie Desta, Betemariam Kebede Gebremicheal. Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review. Int J Microbiol Biotechnol. 2020;5(3):74-82. doi: 10.11648/j.ijmb.20200503.11

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@article{10.11648/j.ijmb.20200503.11,
  author = {Mulatu Workie Desta and Betemariam Kebede Gebremicheal},
  title = {Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review},
  journal = {International Journal of Microbiology and Biotechnology},
  volume = {5},
  number = {3},
  pages = {74-82},
  doi = {10.11648/j.ijmb.20200503.11},
  url = {https://doi.org/10.11648/j.ijmb.20200503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmb.20200503.11},
  abstract = {Turmeric (from Curcuma longa) is a yellow colored spice commonly used in daily diet. It has been extensively used in traditional medicine since ancient times to treat various nervous and disorder disease. A little was known about the biosynthesis curcuminoid in turmeric and identified the enzymes involved in the curcuminoid biosynthetic pathway and confirmed the involvement of the phenylpropanoid pathway in the production of these compounds in plants. Traditionally known curcumin has emerged as a modern biological regulator curcuminoids, agroclimatic and soil environmental variation are also influencing the curcumin synthase gene expression, which is correlated with curcumin yield in turmeric cultivars. Microbial production of curcuminoids is very promising and production yield can be improved by using synthetic biology approaches and metabolic engineering tools, to make heterologous production competitive with the current process of curcuminoid’s extraction from plants. Type III polyketide synthases are responsible for the production of curcuminoids. Among those DCS and CURS enzymes have been used to synthesize curcuminoids. Synthetic biology and metabolite engineering approaches have generated microbial cell factories that can allow the for the mass production of pharmaceutically and nutraceuticals important microbial metabolites in an environmentally friendly and efficient way. Considering a wide pharmaceutical, industrial and health beneficial applications of curcuminoids, this review focused on microbial production of curcuminoids and substrate recognizing and regulatory mechanism of curcuminoid synthase and obtain the mutant enzymes using mutagenesis study and synthetic biology approaches.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Recent Advancement of Microbial Production of Curcuminoids and Its Industrial Applications: A Review
AU  - Mulatu Workie Desta
AU  - Betemariam Kebede Gebremicheal
Y1  - 2020/06/08
PY  - 2020
N1  - https://doi.org/10.11648/j.ijmb.20200503.11
DO  - 10.11648/j.ijmb.20200503.11
T2  - International Journal of Microbiology and Biotechnology
JF  - International Journal of Microbiology and Biotechnology
JO  - International Journal of Microbiology and Biotechnology
SP  - 74
EP  - 82
PB  - Science Publishing Group
SN  - 2578-9686
UR  - https://doi.org/10.11648/j.ijmb.20200503.11
AB  - Turmeric (from Curcuma longa) is a yellow colored spice commonly used in daily diet. It has been extensively used in traditional medicine since ancient times to treat various nervous and disorder disease. A little was known about the biosynthesis curcuminoid in turmeric and identified the enzymes involved in the curcuminoid biosynthetic pathway and confirmed the involvement of the phenylpropanoid pathway in the production of these compounds in plants. Traditionally known curcumin has emerged as a modern biological regulator curcuminoids, agroclimatic and soil environmental variation are also influencing the curcumin synthase gene expression, which is correlated with curcumin yield in turmeric cultivars. Microbial production of curcuminoids is very promising and production yield can be improved by using synthetic biology approaches and metabolic engineering tools, to make heterologous production competitive with the current process of curcuminoid’s extraction from plants. Type III polyketide synthases are responsible for the production of curcuminoids. Among those DCS and CURS enzymes have been used to synthesize curcuminoids. Synthetic biology and metabolite engineering approaches have generated microbial cell factories that can allow the for the mass production of pharmaceutically and nutraceuticals important microbial metabolites in an environmentally friendly and efficient way. Considering a wide pharmaceutical, industrial and health beneficial applications of curcuminoids, this review focused on microbial production of curcuminoids and substrate recognizing and regulatory mechanism of curcuminoid synthase and obtain the mutant enzymes using mutagenesis study and synthetic biology approaches.
VL  - 5
IS  - 3
ER  -

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