Parathyroid adenomas are a very common endocrine entity, whereas parathyroid carcinomas (PC) are extremely rare. With an estimated incidence of 0.015 per 100,000 population and an estimated prevalence of 0.005% in the United States, parathyroid cancer is one of the rarest of all human malignancies. PC is an extremely rare cause of primary hyperparathyroidism (PHPT). Men and women are equally affected, usually in the fourth or fifth decade of life. The exact etiology has not been identified, but mutations in the CDC73 gene appear to have a critical role in its pathogenesis. The morbidity and mortality of PC is secondary to the hypercalcemia resulting from tumor overproduction of PTH. The primary management objectives are complete removal of the cancer and prevention of recurrences. This review will talk about the epidemiology, etiology, clinical manifestations, and management of PC.
| Published in | Journal of Cancer Treatment and Research (Volume 5, Issue 3) |
| DOI | 10.11648/j.jctr.20170503.15 |
| Page(s) | 51-61 |
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2017. Published by Science Publishing Group |
Parathyroid Cancer, Hyperparathyroidism, Hypercalcemia, Parathyroid Carcinoma
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APA Style
Rodrigo Arrangoiz, Fernando Cordera, David Caba, Manuel Muñoz Juarez, Eduardo Moreno, et al. (2017). Current Understanding and Management of Parathyroid Carcinoma. Journal of Cancer Treatment and Research, 5(3), 51-61. https://doi.org/10.11648/j.jctr.20170503.15
ACS Style
Rodrigo Arrangoiz; Fernando Cordera; David Caba; Manuel Muñoz Juarez; Eduardo Moreno, et al. Current Understanding and Management of Parathyroid Carcinoma. J. Cancer Treat. Res. 2017, 5(3), 51-61. doi: 10.11648/j.jctr.20170503.15
AMA Style
Rodrigo Arrangoiz, Fernando Cordera, David Caba, Manuel Muñoz Juarez, Eduardo Moreno, et al. Current Understanding and Management of Parathyroid Carcinoma. J Cancer Treat Res. 2017;5(3):51-61. doi: 10.11648/j.jctr.20170503.15
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Download@article{10.11648/j.jctr.20170503.15,
author = {Rodrigo Arrangoiz and Fernando Cordera and David Caba and Manuel Muñoz Juarez and Eduardo Moreno and Enrique Luque de Leon},
title = {Current Understanding and Management of Parathyroid Carcinoma},
journal = {Journal of Cancer Treatment and Research},
volume = {5},
number = {3},
pages = {51-61},
doi = {10.11648/j.jctr.20170503.15},
url = {https://doi.org/10.11648/j.jctr.20170503.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20170503.15},
abstract = {Parathyroid adenomas are a very common endocrine entity, whereas parathyroid carcinomas (PC) are extremely rare. With an estimated incidence of 0.015 per 100,000 population and an estimated prevalence of 0.005% in the United States, parathyroid cancer is one of the rarest of all human malignancies. PC is an extremely rare cause of primary hyperparathyroidism (PHPT). Men and women are equally affected, usually in the fourth or fifth decade of life. The exact etiology has not been identified, but mutations in the CDC73 gene appear to have a critical role in its pathogenesis. The morbidity and mortality of PC is secondary to the hypercalcemia resulting from tumor overproduction of PTH. The primary management objectives are complete removal of the cancer and prevention of recurrences. This review will talk about the epidemiology, etiology, clinical manifestations, and management of PC.},
year = {2017}
}
TY - JOUR T1 - Current Understanding and Management of Parathyroid Carcinoma AU - Rodrigo Arrangoiz AU - Fernando Cordera AU - David Caba AU - Manuel Muñoz Juarez AU - Eduardo Moreno AU - Enrique Luque de Leon Y1 - 2017/05/31 PY - 2017 N1 - https://doi.org/10.11648/j.jctr.20170503.15 DO - 10.11648/j.jctr.20170503.15 T2 - Journal of Cancer Treatment and Research JF - Journal of Cancer Treatment and Research JO - Journal of Cancer Treatment and Research SP - 51 EP - 61 PB - Science Publishing Group SN - 2376-7790 UR - https://doi.org/10.11648/j.jctr.20170503.15 AB - Parathyroid adenomas are a very common endocrine entity, whereas parathyroid carcinomas (PC) are extremely rare. With an estimated incidence of 0.015 per 100,000 population and an estimated prevalence of 0.005% in the United States, parathyroid cancer is one of the rarest of all human malignancies. PC is an extremely rare cause of primary hyperparathyroidism (PHPT). Men and women are equally affected, usually in the fourth or fifth decade of life. The exact etiology has not been identified, but mutations in the CDC73 gene appear to have a critical role in its pathogenesis. The morbidity and mortality of PC is secondary to the hypercalcemia resulting from tumor overproduction of PTH. The primary management objectives are complete removal of the cancer and prevention of recurrences. This review will talk about the epidemiology, etiology, clinical manifestations, and management of PC. VL - 5 IS - 3 ER -
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