Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas

Josef Dvorak; Bohuslav Melichar; Alzbeta Filipova; Tomas Korinek; Nela Grimova; Jana Grimova; Aneta Rozsypalova; Jan Proks; Tomas Buchler; Igor Richter

doi:doi:10.11648/j.jctr.20180603.11

Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas

Josef Dvorak, Bohuslav Melichar, Alzbeta Filipova, Tomas Korinek, Nela Grimova, Jana Grimova, Aneta Rozsypalova, Jan Proks, Tomas Buchler, Igor Richter

Published in Journal of Cancer Treatment and Research (Volume 6, Issue 3)

Received: 19 August 2018 Accepted: 11 October 2018 Published: 7 November 2018

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: The primary cilium is a solitary, chemosensory and mechanosensory, non-motile microtubule-based organelle which in the quiescent cell cycle phase projects from the surface of most cells in vertebrates, including humans. A hypothesis has been proposed that the cell endogenous electromagnetic field results from a unique cooperating system among microtubules and mitochondria. The present study expands this prior hypothesis of the endogenous electromagnetic field in the cell to the present hypothesis that primary cilium could serve as a monopole antenna. It is proposed that primary cilia as monopole antennas can serve for both transmitting and receiving signals at the same frequency. Results: There was simulated the distribution of electric field of primary cilium as a monopole antenna of a single cell, primary cilia after mitosis and primary cilium of renal tubule in water environment. According to simulations of the distribution of electric field of primary cilium as a monopole antenna, the electromagnetic waves radiate not only to the neighbouring cells, but also to the nucleus of the cell proper where the gene expression during the cell cycle could be changed. Conclusions: The present study provides the first simulations of electromagnetic field of primary cilia as monopole antennas. The proof of this function of primary cilia could extend diagnostic and therapeutic modalities. There are several ways to verify this hypothesis. For example, it is possible to use the voltage sensitive dyes in the microenvironment outside the primary cilium or photon counting with low noise and highly sensitive photon counting system.

Published in	Journal of Cancer Treatment and Research (Volume 6, Issue 3)
DOI	10.11648/j.jctr.20180603.11
Page(s)	37-43
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Primary Cilia, Monopole Antennas, Distribution of Electric Field Models

References

[1]	Basten SG, Giles RH. Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis. Cilia 2013; 2:6.
[2]	Fröhlich H. Long-range coherence and energy storage in biological systems. Int J Quant Chem 1968; 2:641-49.
[3]	Cifra M, Fields JZ, Farhadi A. Electromagnetic cellular interactions. Prog Biophys Mol Biol 2011; 105:223-46.
[4]	Pokorny J, Vedruccio C, Cifra M, Kucera O. Cancer physics: diagnostics based on damped cellular elastoelectrical vibrations in microtubules. Eur Biophys J 2011; 40:747-59.
[5]	Pokorny J, Pokorny J, Foletti A, Kobilkova J, Vrba J, Vrba J. Mitochondrial dysfunction and disturbed coherence: gate to cancer. Pharmaceuticals (Basel) 2015; 8:675-95.
[6]	Tyner KM, Kopelman R, Philbert MA. "Nano-sized voltmeter" enables cellular-wide electric field mapping. Biophysical Journal 2007; 93:1163-11.
[7]	Pokorny J, Pokorny J, Borodavka F. Warburg effect-damping of electromagnetic oscillations. Electromagn Biol Med 2017; 36:1-9.
[8]	Dvorak J, Melichar B, Filipova A, Grimova J, Grimova N, Rozsypalova A, et al. Simulations of centriole of polarized centrosome as a monopole antenna in immune and viral synapses. Special article J BUON 2018; 23(2):514-21.
[9]	Balanis CA. Antenna Theory: Analysis and Design, 4th ed. Hoboken, New Jersey, USA: John Wiley & Sons, Inc.; 2016.
[10]	Minoura I, Muto E. Dielectric measurement of individual microtubules using the electroorientation method. Biophys J 2006; 90: 3739-48.
[11]	Lamprecht I. Growth and metabolism in yeasts. In: Beezer AE, editor. Biological microcalorimetry. London: Academic Press; 1980. p. 43-112.
[12]	Pan J, Snell W. The primary cilium: keeper of the key to cell division. Cell 2007; 129:1255-7.
[13]	Lefebvre PA, Nordstrom SA, Moulder JE, Rosenbaum JL. Flagellar elongation and shortening in Chlamydomonas. IV. Effects of flagellar detachment, regeneration, and resorption on the induction of flagellar protein synthesis. J Cell Biol 1978; 78:8-27.
[14]	Izawa I, Goto H, Kasahara K, Inagaki M. Current topics of functional links between primary cilia and cell cycle. Cilia 2015; 4:12.
[15]	Anderson CT, Stearns T. Centriole age underlies asynchronous primary cilium growth in mammalian cells. Curr Biol 2009; 19:1498-502.
[16]	Yamashita YM, Mahowald AP, Perlin JR, Fuller MT. Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science2007; 315:518-21.
[17]	Benzing T, Walz G. Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypertens 2006; 15:245-9.
[18]	Priel A, Tuszynski, Cantiello H. Electrodynamic signaling by the dendritic cytoskeleton: toward an intracellular information processing model. Electromagnetic Biology and Medicine 2005; 24: 221-31.
[19]	Havelka D, Kucera O, Deriu MA, Cifra M. Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model. PLoS One 2014; 9:e86501. doi: 10.1371/journal.pone.0086501.
[20]	Alexandrov BS, Rasmussen KØ, Bishop AR, Usheva A, Alexandrov LB, Chong S, et al. Non-thermal effects of terahertz radiation on gene expression in mouse stem cells. Biomed Opt Express 2011; 2:2679-89.
[21]	Chai BH, Zheng JM, Zhao Q, Pollack GH. Spectroscopic studies of solutes in aqueous solution. J Phys Chem A 2008; 112:2242-7.
[22]	Menzl I, Lebeau L, Pande R, Hassounah NB, Li FW, Nagle R, Weihs K, McDermott KM. Loss of primary cilia occurs early in breast cancer development. Cilia 2014; 3:7.
[23]	Gradilone SA, Radtke BN, Bogert PS, Huang BQ, Gajdos GB, LaRusso N. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res 2013; 73:2259-70.
[24]	Dvorak J, Hadzi Nikolov D, Dusek L, Filipova A, Richter I, Buka D, et al. Prognostic significance of the frequency of primary cilia in cells of small bowel and colorectal adenocarcinoma. J BUON 2016; 21:1233-41.
[25]	Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH Jr, et al. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med 2009; 15:1055-61.
[26]	Lee H, Song J, Jung JH, Ko HW. Primary cilia in energy balance signaling and metabolic disorder. BMB Rep 2015; 48:647-54.
[27]	Jain R, Pan J, Driscoll JA, Wisner JW, Huang T, Gunsten SP, et al. Temporal relationship between primary and motile ciliogenesis in airway epithelial cells. Am J Respir Cell Mol Biol 2010; 43:731-9.
[28]	Fuchs JL, Schwark HD. Neuronal primary cilia: a review. Cell Biol Int 2004; 28:111- 8.
[29]	Pohl HA. Braden T, Robinson S, Piclardi J, Pohl DG. Life cycle alteration of the micro-dielectrophoretic effects of cells. J Biol Phys 1981; 9:133-54.
[30]	Kucera O, Cifra M, Pokorny J. Technical aspects of measurement of cellular electromagnetic activity. Eur Biophys J 2010; 39:1465-70.

Cite This Article

Plain Text BibTeX RIS

APA Style

Josef Dvorak, Bohuslav Melichar, Alzbeta Filipova, Tomas Korinek, Nela Grimova, et al. (2018). Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas. Journal of Cancer Treatment and Research, 6(3), 37-43. https://doi.org/10.11648/j.jctr.20180603.11

Copy | Download

ACS Style

Josef Dvorak; Bohuslav Melichar; Alzbeta Filipova; Tomas Korinek; Nela Grimova, et al. Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas. J. Cancer Treat. Res. 2018, 6(3), 37-43. doi: 10.11648/j.jctr.20180603.11

Copy | Download

AMA Style

Josef Dvorak, Bohuslav Melichar, Alzbeta Filipova, Tomas Korinek, Nela Grimova, et al. Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas. J Cancer Treat Res. 2018;6(3):37-43. doi: 10.11648/j.jctr.20180603.11

Copy | Download

@article{10.11648/j.jctr.20180603.11,
  author = {Josef Dvorak and Bohuslav Melichar and Alzbeta Filipova and Tomas Korinek and Nela Grimova and Jana Grimova and Aneta Rozsypalova and Jan Proks and Tomas Buchler and Igor Richter},
  title = {Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas},
  journal = {Journal of Cancer Treatment and Research},
  volume = {6},
  number = {3},
  pages = {37-43},
  doi = {10.11648/j.jctr.20180603.11},
  url = {https://doi.org/10.11648/j.jctr.20180603.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20180603.11},
  abstract = {Background: The primary cilium is a solitary, chemosensory and mechanosensory, non-motile microtubule-based organelle which in the quiescent cell cycle phase projects from the surface of most cells in vertebrates, including humans. A hypothesis has been proposed that the cell endogenous electromagnetic field results from a unique cooperating system among microtubules and mitochondria. The present study expands this prior hypothesis of the endogenous electromagnetic field in the cell to the present hypothesis that primary cilium could serve as a monopole antenna. It is proposed that primary cilia as monopole antennas can serve for both transmitting and receiving signals at the same frequency. Results: There was simulated the distribution of electric field of primary cilium as a monopole antenna of a single cell, primary cilia after mitosis and primary cilium of renal tubule in water environment. According to simulations of the distribution of electric field of primary cilium as a monopole antenna, the electromagnetic waves radiate not only to the neighbouring cells, but also to the nucleus of the cell proper where the gene expression during the cell cycle could be changed. Conclusions: The present study provides the first simulations of electromagnetic field of primary cilia as monopole antennas. The proof of this function of primary cilia could extend diagnostic and therapeutic modalities. There are several ways to verify this hypothesis. For example, it is possible to use the voltage sensitive dyes in the microenvironment outside the primary cilium or photon counting with low noise and highly sensitive photon counting system.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas
AU  - Josef Dvorak
AU  - Bohuslav Melichar
AU  - Alzbeta Filipova
AU  - Tomas Korinek
AU  - Nela Grimova
AU  - Jana Grimova
AU  - Aneta Rozsypalova
AU  - Jan Proks
AU  - Tomas Buchler
AU  - Igor Richter
Y1  - 2018/11/07
PY  - 2018
N1  - https://doi.org/10.11648/j.jctr.20180603.11
DO  - 10.11648/j.jctr.20180603.11
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 37
EP  - 43
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20180603.11
AB  - Background: The primary cilium is a solitary, chemosensory and mechanosensory, non-motile microtubule-based organelle which in the quiescent cell cycle phase projects from the surface of most cells in vertebrates, including humans. A hypothesis has been proposed that the cell endogenous electromagnetic field results from a unique cooperating system among microtubules and mitochondria. The present study expands this prior hypothesis of the endogenous electromagnetic field in the cell to the present hypothesis that primary cilium could serve as a monopole antenna. It is proposed that primary cilia as monopole antennas can serve for both transmitting and receiving signals at the same frequency. Results: There was simulated the distribution of electric field of primary cilium as a monopole antenna of a single cell, primary cilia after mitosis and primary cilium of renal tubule in water environment. According to simulations of the distribution of electric field of primary cilium as a monopole antenna, the electromagnetic waves radiate not only to the neighbouring cells, but also to the nucleus of the cell proper where the gene expression during the cell cycle could be changed. Conclusions: The present study provides the first simulations of electromagnetic field of primary cilia as monopole antennas. The proof of this function of primary cilia could extend diagnostic and therapeutic modalities. There are several ways to verify this hypothesis. For example, it is possible to use the voltage sensitive dyes in the microenvironment outside the primary cilium or photon counting with low noise and highly sensitive photon counting system.
VL  - 6
IS  - 3
ER  -

Copy | Download

Author Information

Josef Dvorak

Department of Oncology, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
Bohuslav Melichar

Department of Oncology, Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic
Alzbeta Filipova

Department of Radiobiology, Faculty of Military Health Sciences in Hradec Kralove, University of Defense in Brno, Hradec Kralove, Czech Republic
Tomas Korinek

Department of Electromagnetic Field, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic
Nela Grimova

Department of Cybernetics, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic
Jana Grimova

Medicon, Prague, Czech Republic
Aneta Rozsypalova

Department of Oncology, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
Jan Proks

Department of Oncology, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
Tomas Buchler

Department of Oncology, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
Igor Richter

Department of Oncology, Regional Hospital, Liberec, Czech Republic

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Josef Dvorak, Bohuslav Melichar, Alzbeta Filipova, Tomas Korinek, Nela Grimova, et al. (2018). Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas. Journal of Cancer Treatment and Research, 6(3), 37-43. https://doi.org/10.11648/j.jctr.20180603.11

Copy | Download

ACS Style

Josef Dvorak; Bohuslav Melichar; Alzbeta Filipova; Tomas Korinek; Nela Grimova, et al. Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas. J. Cancer Treat. Res. 2018, 6(3), 37-43. doi: 10.11648/j.jctr.20180603.11

Copy | Download

AMA Style

Josef Dvorak, Bohuslav Melichar, Alzbeta Filipova, Tomas Korinek, Nela Grimova, et al. Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas. J Cancer Treat Res. 2018;6(3):37-43. doi: 10.11648/j.jctr.20180603.11

Copy | Download

@article{10.11648/j.jctr.20180603.11,
  author = {Josef Dvorak and Bohuslav Melichar and Alzbeta Filipova and Tomas Korinek and Nela Grimova and Jana Grimova and Aneta Rozsypalova and Jan Proks and Tomas Buchler and Igor Richter},
  title = {Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas},
  journal = {Journal of Cancer Treatment and Research},
  volume = {6},
  number = {3},
  pages = {37-43},
  doi = {10.11648/j.jctr.20180603.11},
  url = {https://doi.org/10.11648/j.jctr.20180603.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20180603.11},
  abstract = {Background: The primary cilium is a solitary, chemosensory and mechanosensory, non-motile microtubule-based organelle which in the quiescent cell cycle phase projects from the surface of most cells in vertebrates, including humans. A hypothesis has been proposed that the cell endogenous electromagnetic field results from a unique cooperating system among microtubules and mitochondria. The present study expands this prior hypothesis of the endogenous electromagnetic field in the cell to the present hypothesis that primary cilium could serve as a monopole antenna. It is proposed that primary cilia as monopole antennas can serve for both transmitting and receiving signals at the same frequency. Results: There was simulated the distribution of electric field of primary cilium as a monopole antenna of a single cell, primary cilia after mitosis and primary cilium of renal tubule in water environment. According to simulations of the distribution of electric field of primary cilium as a monopole antenna, the electromagnetic waves radiate not only to the neighbouring cells, but also to the nucleus of the cell proper where the gene expression during the cell cycle could be changed. Conclusions: The present study provides the first simulations of electromagnetic field of primary cilia as monopole antennas. The proof of this function of primary cilia could extend diagnostic and therapeutic modalities. There are several ways to verify this hypothesis. For example, it is possible to use the voltage sensitive dyes in the microenvironment outside the primary cilium or photon counting with low noise and highly sensitive photon counting system.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas
AU  - Josef Dvorak
AU  - Bohuslav Melichar
AU  - Alzbeta Filipova
AU  - Tomas Korinek
AU  - Nela Grimova
AU  - Jana Grimova
AU  - Aneta Rozsypalova
AU  - Jan Proks
AU  - Tomas Buchler
AU  - Igor Richter
Y1  - 2018/11/07
PY  - 2018
N1  - https://doi.org/10.11648/j.jctr.20180603.11
DO  - 10.11648/j.jctr.20180603.11
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 37
EP  - 43
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20180603.11
AB  - Background: The primary cilium is a solitary, chemosensory and mechanosensory, non-motile microtubule-based organelle which in the quiescent cell cycle phase projects from the surface of most cells in vertebrates, including humans. A hypothesis has been proposed that the cell endogenous electromagnetic field results from a unique cooperating system among microtubules and mitochondria. The present study expands this prior hypothesis of the endogenous electromagnetic field in the cell to the present hypothesis that primary cilium could serve as a monopole antenna. It is proposed that primary cilia as monopole antennas can serve for both transmitting and receiving signals at the same frequency. Results: There was simulated the distribution of electric field of primary cilium as a monopole antenna of a single cell, primary cilia after mitosis and primary cilium of renal tubule in water environment. According to simulations of the distribution of electric field of primary cilium as a monopole antenna, the electromagnetic waves radiate not only to the neighbouring cells, but also to the nucleus of the cell proper where the gene expression during the cell cycle could be changed. Conclusions: The present study provides the first simulations of electromagnetic field of primary cilia as monopole antennas. The proof of this function of primary cilia could extend diagnostic and therapeutic modalities. There are several ways to verify this hypothesis. For example, it is possible to use the voltage sensitive dyes in the microenvironment outside the primary cilium or photon counting with low noise and highly sensitive photon counting system.
VL  - 6
IS  - 3
ER  -

Copy | Download