@article{10.11648/j.jctr.20221003.12,
  author = {Mayte Lima Pérez and Jorge Luis Soriano García and Jorge Luis Soriano-Lorenzo and Vilma Fleites Calvo and Masiel González Meisozo and Dunia Morales Morgado and Raidel Rodríguez Barrios and Carlos Domínguez Álvarez},
  title = {Value of Prognostic Nutritional Index for Predicting Survival in Patients with Advanced Esophageal Squamous Cell Carcinoma Treated with Chemoradiotherapy},
  journal = {Journal of Cancer Treatment and Research},
  volume = {10},
  number = {3},
  pages = {31-37},
  doi = {10.11648/j.jctr.20221003.12},
  url = {https://doi.org/10.11648/j.jctr.20221003.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20221003.12},
  abstract = {Background: Esophageal cancer is the sixth leading cause of cancer-related death worldwide. Despite the advances in the surgical approach, chemotherapy and radiotherapy regimens, and the continuous development of biological agents, survival outcomes for these patients remain low. The identification of new biomarkers capable of predicting worse survival regardless of the clinical stage is necessary. Purpose: The aim of this study is to evaluate the association between Prognostic Nutritional Index (PNI) and overall survival in patients with advanced squamous esophageal carcinoma. Methods: A retrospective and observational study was conducted in patients with diagnosis of advanced esophageal squamous cell carcinoma treated at Hermanos Ameijeiras Hospital from January 2013 to June 2019. The PNI was calculated using the following formula: 10 x Albumin (g/dL) + 0.005 x Lymphocyte counts (x109). Results: A total of 94 patients were enrolled in this study. The area under the curve (AUC) was 0,583 and the optimal cut-off value was 40. PNI was significantly associated with hemoglobin level, platelet count, total lymphocyte count, neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), and therapeutic response. PNI was negatively correlated with inflammatory indexes. Patients with PNI ˂40 had a significantly shorter median overall survival compared to patients with PNI ≥40. Multivariate analysis identified that ECOG ≥1, platelet count, NLR≥4 and PNI˂40 were independent prognostic factors for poor overall survival. Conclusion: The present study demonstrated that pretreatment PNI is a useful marker for predicting survival outcome in patients with advanced esophageal squamous cell carcinoma.},
 year = {2022}
}

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TY  - JOUR
T1  - Value of Prognostic Nutritional Index for Predicting Survival in Patients with Advanced Esophageal Squamous Cell Carcinoma Treated with Chemoradiotherapy
AU  - Mayte Lima Pérez
AU  - Jorge Luis Soriano García
AU  - Jorge Luis Soriano-Lorenzo
AU  - Vilma Fleites Calvo
AU  - Masiel González Meisozo
AU  - Dunia Morales Morgado
AU  - Raidel Rodríguez Barrios
AU  - Carlos Domínguez Álvarez
Y1  - 2022/11/16
PY  - 2022
N1  - https://doi.org/10.11648/j.jctr.20221003.12
DO  - 10.11648/j.jctr.20221003.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 31
EP  - 37
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20221003.12
AB  - Background: Esophageal cancer is the sixth leading cause of cancer-related death worldwide. Despite the advances in the surgical approach, chemotherapy and radiotherapy regimens, and the continuous development of biological agents, survival outcomes for these patients remain low. The identification of new biomarkers capable of predicting worse survival regardless of the clinical stage is necessary. Purpose: The aim of this study is to evaluate the association between Prognostic Nutritional Index (PNI) and overall survival in patients with advanced squamous esophageal carcinoma. Methods: A retrospective and observational study was conducted in patients with diagnosis of advanced esophageal squamous cell carcinoma treated at Hermanos Ameijeiras Hospital from January 2013 to June 2019. The PNI was calculated using the following formula: 10 x Albumin (g/dL) + 0.005 x Lymphocyte counts (x109). Results: A total of 94 patients were enrolled in this study. The area under the curve (AUC) was 0,583 and the optimal cut-off value was 40. PNI was significantly associated with hemoglobin level, platelet count, total lymphocyte count, neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), and therapeutic response. PNI was negatively correlated with inflammatory indexes. Patients with PNI ˂40 had a significantly shorter median overall survival compared to patients with PNI ≥40. Multivariate analysis identified that ECOG ≥1, platelet count, NLR≥4 and PNI˂40 were independent prognostic factors for poor overall survival. Conclusion: The present study demonstrated that pretreatment PNI is a useful marker for predicting survival outcome in patients with advanced esophageal squamous cell carcinoma.
VL  - 10
IS  - 3
ER  - 

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