Desmoid tumors are benign tumor of connective tissue but with high chances of local recurrence. Surgery is the main treatment modality of therapy if it can be done with acceptable morbidity. Our purpose to present our experience in management of desmoid tumors and our aim is to evaluate the best option in dealing with desmoid tumors and factors affecting the Recurrence Free Survival. This is retrospective trial so medical records of patients diagnosed as desmoid tumors between January 2009 and December 2018 were reviewed at Radiation Oncology section, King Faisal Specialist Hospital & Research Centre (KFSH&RC), Riyadh, Saudi Arabia. Our cohort was 72 consecutive patients. The median age was 27 years, two-thirds were females, median size was 7 cm and most common site was trunk. Twenty four patients were treated with definitive radiotherapy, 15 patients by surgical resection alone and 30 patients by combination of both surgery and radiotherapy. The median follow up was 5.5 years with local control in patients who had radiotherapy as part of treatment was 89% and 87% in patients who had surgery as a part of treatment. The patients who had surgery alone had no recurrence. All the recurrences happened in the lower radiotherapy dose of 50Gy and those who had postoperative radiotherapy. There was no recurrence in the higher radiotherapy dose of 60Gy and those who had preoperative radiotherapy. Most of the recurrence was in patients with tumor size less than 5 cm, in the extremities and in the less than 30 years old group. The 3 years, 5 years and 7years Recurrence Free Survival in patients who had both surgery and radiotherapy was 96.4%, 81.4% and 77.4% respectively. Radiotherapy plays an important role in local control of desmoid tumors. The factors associated with poor response in the cohort of patients are younger age group, lower dose of radiation and post-operative radiotherapy compared to preoperative radiotherapy. The majority of the recurrent tumors were small indicating that biology of the disease is more important.
| Published in | Journal of Cancer Treatment and Research (Volume 10, Issue 4) |
| DOI | 10.11648/j.jctr.20221004.11 |
| Page(s) | 38-42 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Desmoid, Tumor, Treatment, Outcome
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APA Style
Mohamed Wahba Hegazy, Mohamed Rizwanullah. (2022). Desmoid Tumour Treatment Outcome: A Single Institution Experience. Journal of Cancer Treatment and Research, 10(4), 38-42. https://doi.org/10.11648/j.jctr.20221004.11
ACS Style
Mohamed Wahba Hegazy; Mohamed Rizwanullah. Desmoid Tumour Treatment Outcome: A Single Institution Experience. J. Cancer Treat. Res. 2022, 10(4), 38-42. doi: 10.11648/j.jctr.20221004.11
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Download@article{10.11648/j.jctr.20221004.11,
author = {Mohamed Wahba Hegazy and Mohamed Rizwanullah},
title = {Desmoid Tumour Treatment Outcome: A Single Institution Experience},
journal = {Journal of Cancer Treatment and Research},
volume = {10},
number = {4},
pages = {38-42},
doi = {10.11648/j.jctr.20221004.11},
url = {https://doi.org/10.11648/j.jctr.20221004.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20221004.11},
abstract = {Desmoid tumors are benign tumor of connective tissue but with high chances of local recurrence. Surgery is the main treatment modality of therapy if it can be done with acceptable morbidity. Our purpose to present our experience in management of desmoid tumors and our aim is to evaluate the best option in dealing with desmoid tumors and factors affecting the Recurrence Free Survival. This is retrospective trial so medical records of patients diagnosed as desmoid tumors between January 2009 and December 2018 were reviewed at Radiation Oncology section, King Faisal Specialist Hospital & Research Centre (KFSH&RC), Riyadh, Saudi Arabia. Our cohort was 72 consecutive patients. The median age was 27 years, two-thirds were females, median size was 7 cm and most common site was trunk. Twenty four patients were treated with definitive radiotherapy, 15 patients by surgical resection alone and 30 patients by combination of both surgery and radiotherapy. The median follow up was 5.5 years with local control in patients who had radiotherapy as part of treatment was 89% and 87% in patients who had surgery as a part of treatment. The patients who had surgery alone had no recurrence. All the recurrences happened in the lower radiotherapy dose of 50Gy and those who had postoperative radiotherapy. There was no recurrence in the higher radiotherapy dose of 60Gy and those who had preoperative radiotherapy. Most of the recurrence was in patients with tumor size less than 5 cm, in the extremities and in the less than 30 years old group. The 3 years, 5 years and 7years Recurrence Free Survival in patients who had both surgery and radiotherapy was 96.4%, 81.4% and 77.4% respectively. Radiotherapy plays an important role in local control of desmoid tumors. The factors associated with poor response in the cohort of patients are younger age group, lower dose of radiation and post-operative radiotherapy compared to preoperative radiotherapy. The majority of the recurrent tumors were small indicating that biology of the disease is more important.},
year = {2022}
}
TY - JOUR T1 - Desmoid Tumour Treatment Outcome: A Single Institution Experience AU - Mohamed Wahba Hegazy AU - Mohamed Rizwanullah Y1 - 2022/12/27 PY - 2022 N1 - https://doi.org/10.11648/j.jctr.20221004.11 DO - 10.11648/j.jctr.20221004.11 T2 - Journal of Cancer Treatment and Research JF - Journal of Cancer Treatment and Research JO - Journal of Cancer Treatment and Research SP - 38 EP - 42 PB - Science Publishing Group SN - 2376-7790 UR - https://doi.org/10.11648/j.jctr.20221004.11 AB - Desmoid tumors are benign tumor of connective tissue but with high chances of local recurrence. Surgery is the main treatment modality of therapy if it can be done with acceptable morbidity. Our purpose to present our experience in management of desmoid tumors and our aim is to evaluate the best option in dealing with desmoid tumors and factors affecting the Recurrence Free Survival. This is retrospective trial so medical records of patients diagnosed as desmoid tumors between January 2009 and December 2018 were reviewed at Radiation Oncology section, King Faisal Specialist Hospital & Research Centre (KFSH&RC), Riyadh, Saudi Arabia. Our cohort was 72 consecutive patients. The median age was 27 years, two-thirds were females, median size was 7 cm and most common site was trunk. Twenty four patients were treated with definitive radiotherapy, 15 patients by surgical resection alone and 30 patients by combination of both surgery and radiotherapy. The median follow up was 5.5 years with local control in patients who had radiotherapy as part of treatment was 89% and 87% in patients who had surgery as a part of treatment. The patients who had surgery alone had no recurrence. All the recurrences happened in the lower radiotherapy dose of 50Gy and those who had postoperative radiotherapy. There was no recurrence in the higher radiotherapy dose of 60Gy and those who had preoperative radiotherapy. Most of the recurrence was in patients with tumor size less than 5 cm, in the extremities and in the less than 30 years old group. The 3 years, 5 years and 7years Recurrence Free Survival in patients who had both surgery and radiotherapy was 96.4%, 81.4% and 77.4% respectively. Radiotherapy plays an important role in local control of desmoid tumors. The factors associated with poor response in the cohort of patients are younger age group, lower dose of radiation and post-operative radiotherapy compared to preoperative radiotherapy. The majority of the recurrent tumors were small indicating that biology of the disease is more important. VL - 10 IS - 4 ER -
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