Archive:: International Journal of Genetics and Genomics:: Science Publishing Group

Volume 13, Issue 1, March 2025

Review Article
Challenges and Advances in Diagnosing and Treating Hypophosphatasia in Adults: A Comprehensive Review

Sandeep Bolla^*

Issue: Volume 13, Issue 1, March 2025

Pages: 1-9

Received: 10 December 2024

Accepted: 3 January 2025

Published: 22 January 2025

DOI: 10.11648/j.ijgg.20251301.11

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Abstract: Hypophosphatasia (HPP), a rare metabolic disorder caused by mutations in the ALPL gene, leads to deficient alkaline phosphatase activity and presents unique clinical challenges for adult patients, including fractures, chronic pain, and dental issues. This disorder is often underdiagnosed due to its variable clinical presentation and overlap with ot... Show More

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Research Article
Polymorphism of the rs12255372 Allele of the TCF7L2 Gene Associated with Predisposition to Type 2 Diabete Using SNP Markers in a Population in the North of the Côte d’Ivoire

Dagnogo Oléfongo^*, Dago Dougba Noel, Yeo Tenedjoh Korotoum, Kouman Kouamé Bouatini Angélo, Coulibaly N'golo David, Djaman Allico Joseph

Issue: Volume 13, Issue 1, March 2025

Pages: 10-19

Received: 20 January 2025

Accepted: 7 February 2025

Published: 27 February 2025

DOI: 10.11648/j.ijgg.20251301.12

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Abstract: Background: Type 2 diabetes (T2D) is a chronic metabolic disease characterised by hyperglycaemia due to insulin resistance and impaired insulin secretion. Genetic and environmental factors can influence predisposition to this disease. Genetic predisposition plays a significant role in the risk of developing the disease, and the TCF7L2 (T-Cell Facto... Show More

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