Research Article
Correlation Between Serum Level of TSH Receptor Antibody and Severity of Graves’ Orbitopathy
Karim Nasr El Din Abbas,
Sheriff Elwan,
Radwa Elsherif*,
Mina Nesim,
Mahmoud Elsamkary
Issue:
Volume 10, Issue 3, September 2025
Pages:
42-49
Received:
14 May 2025
Accepted:
3 June 2025
Published:
21 July 2025
DOI:
10.11648/j.ijovs.20251003.11
Downloads:
Views:
Abstract: Purpose: evaluating relationship between serum level of TSH Receptor Antibody (TRAb) and severity of Graves’ ophthalmopathy (GO). Methods: prospective interventional follow up study included 35 newly diagnosed untreated patients with GO was carried at Ain Shams University Hospital, Cairo. patients were subjected to full ophthalmological examination, measuring proptosis degree by Hertel’s Exophthalmometer, measuring TRAb serum level. patients were classified according to clinical activity score into 2 groups: Inactive [CAS < 3]: 23 patients received only antithyroid therapy and Active [CAS ≥ 3]: 12 patients received intravenous methylprednisolone at a dose of 0.5gm for 6 weeks, injected weekly. 6 weeks after treatment severity of (GO), proptosis, and TRAb serum level were reassessed. Results: study found the mean CAS was 2.11±1.13, the mean proptosis measured (23.26 ±3.19) and (22.42 ± 3.27) in right and left eye respectively while mean of TRAb was 11.19 ±6.45. After 6 weeks of treatment, CAS was regressed significantly in relation to TRAb level as TRAb measurement decreased by -62.7%, -14.06% in group II and group I respectively while proptosis measurement of right and left eyes in group II significantly decreased, with mean changes of -10.3% and -10.7%, respectively. And, in group I (-4.5% and -3.8%) in right and left eyes respectively, but not significant to TRAb level. Conclusion TRAb level can be used as monitor to activity of Grave’s Ophthalmopathy (GO) and in follow up but not directly related to proptosis degree.
Abstract: Purpose: evaluating relationship between serum level of TSH Receptor Antibody (TRAb) and severity of Graves’ ophthalmopathy (GO). Methods: prospective interventional follow up study included 35 newly diagnosed untreated patients with GO was carried at Ain Shams University Hospital, Cairo. patients were subjected to full ophthalmological examination...
Show More
