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Discovery of Meridian Entities and the Third Regulatory Framework
Issue:
Volume 9, Issue 5, October 2021
Pages:
230-235
Received:
8 August 2021
Accepted:
31 August 2021
Published:
8 September 2021
Abstract: Human diseases are the result of neuromodulation and humoral regulation disorders. However, the Chinese people have carried out acupuncture experiments on the body for thousands of years, and their curative effects have convinced them that the meridians and acupoint structure based on acupuncture and moxibustion is not a simple mechanism of nerve conduction and humoral regulation. This study adopts "Xu's pulse diagnosis Intangible Cultural Heritage Inheritance technology". According to "Lingshu · meridians", the pulse on the skin surface of the whole body was perceived. Pulse diagnosis found that there were longitudinal and transverse pulsating thin lines on the body surface. Then through the meridian pen to test the vertical and horizontal conduction path, acupuncture to verify the clinical effect, and local anatomy to confirm the existence of meridian and acupoint entities in the human body. Finally, it is determined that there are 31 pairs of transverse meridians and 13 pairs of longitudinal meridians in human epidermis and dermis. It is highly consistent with the meridian path of the twelve meridians, the odd meridians and the eight meridians of traditional Chinese medicine, and the position of acupoints is also highly consistent. According to the new development of skin anatomy, this paper expounds the physiological and pathological regulation mechanism of meridian structure, and determines that there is an artificial external regulation system based on vertical and horizontal meridian structure in human body.
Abstract: Human diseases are the result of neuromodulation and humoral regulation disorders. However, the Chinese people have carried out acupuncture experiments on the body for thousands of years, and their curative effects have convinced them that the meridians and acupoint structure based on acupuncture and moxibustion is not a simple mechanism of nerve c...
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Evaluation of C-peptide in Type 2 Diabetic Patient in Douala Cameroon: C-peptide Correlation with BMI and Duration of Diabetes
Manta Diane,
Mbango-Ekouta Noel Désirée,
Nda Mefo'o Jean Pierre,
Assiene Oyong Damase Serge,
Eloumou Bagnaka Servais,
Adiogo Dieudonné
Issue:
Volume 9, Issue 5, October 2021
Pages:
236-238
Received:
2 August 2021
Accepted:
26 August 2021
Published:
11 September 2021
Abstract: Introduction: The C-peptide assay is the more reliable indicator of insulin secretion than insulin itself, making it possible to optimize the treatment and to anticipate the evolution of complications linked to type 2 diabetes. The present study reports the relationship between the levels of C-peptide, the body mass index and the duration of type 2 diabetes in two hospitals (General Hospital and Gyneco-Obstetric and Pediatric Hospital) in the city of Douala Cameroon. The aim of this study was to assess relationship between serum C-peptide levels with some patient characteristics such as duration in type 2 diabetes and obesity. Methods: We carried out an analytical cross-sectional study over a period of 9 months of patients with type 2 diabetes regularly monitored at the General Hospital and Gyneco-Obstetric and Pediatric Hospital of Douala Cameroon. We included any patient whose diagnosis of type 2 diabetes was mentioned in the medical file. The C-peptide assays after fasting blood sampling were carried out according to the principle of electro-chemiluminescence assay. The ANOVA and PEARSON tests made it possible to compare groups and look for correlations between C-peptide and other variables. The significant threshold was set at P˂0.05. Results: We included 90 subjects with a mean age of 58±12.31 years. The average BMI was 28.18±5.51 kg/m2. The mean duration of diabetes was 8.71±6.94 years, the mean C-peptide level was 2.50±1.68 ng/ml. We found that C-Peptide levels increased with body mass index (P=0.004) and patient age (P=0.004). Conversely, we found that C-peptide levels increased with duration of diabetes but not significantly (P=0.411). Conclusion: The C-peptide levels make it possible to objectify the residual secretion of pancreatic beta cells. We found that C-peptide levels increases with increasing body mass index, but they were no significant correlation between C-peptide levels and the diabetes duration.
Abstract: Introduction: The C-peptide assay is the more reliable indicator of insulin secretion than insulin itself, making it possible to optimize the treatment and to anticipate the evolution of complications linked to type 2 diabetes. The present study reports the relationship between the levels of C-peptide, the body mass index and the duration of type 2...
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The Vascular Endothelial Growth Factor’s Expression in Gastric Cancer and Progress in Prognostic Research
Li Hongyan,
Zhang Shuli,
Hou Jianzhang
Issue:
Volume 9, Issue 5, October 2021
Pages:
239-247
Received:
30 August 2021
Accepted:
17 September 2021
Published:
30 September 2021
Abstract: Gastric cancer (GC) is not only one of the common gastrointestinal malignancies in clinic, but also the most common cancer in the world. In recent years, its morbidity has increased. The global morbidity and mortality of gastric cancer rank fifth among all malignancies. The morbidity and mortality of gastric cancer in our country ranks second among malignant tumors, which is twice as high as the world average. In rural, the number is 1.6 times of in urban. The early diagnosis of most gastric cancers is rare in majority of patients, and most of them are in intermediate or advanced stage when they are in treatment. The proportion of radical surgery is not high, and it is easy to relapse and metastasize. The 5-year survival rate is about 40%, and the treatment effect is poor, which is severely harmful to people’s health. Although the pathogenesis of gastric cancer is related to many factors, the nosogenesis is vague. The occurrence of tumors is closely related to the formation of new blood vessels. New blood vessels are the internal conditions for tumor cell proliferation and metastasis. The factors that promoting angiogenesis include more than 10 kinds of fibroblast growth factors (FGFs) and vascular endothelial growth factors (VEGF), among which VEGF is the most important regulator that promotes angiogenesis. By promoting the mitosis of vascular endothelial cells, it forms an essential matrix for the growth of vascular endothelial cells, plays a crucial regulatory role in the process of tumor angiogenesis, and participates in the occurrence and development of a variety of tumor cells. This article summarizes the research progress on the vascular endothelial growth factor’s expression in gastric cancer and prognostics follows.
Abstract: Gastric cancer (GC) is not only one of the common gastrointestinal malignancies in clinic, but also the most common cancer in the world. In recent years, its morbidity has increased. The global morbidity and mortality of gastric cancer rank fifth among all malignancies. The morbidity and mortality of gastric cancer in our country ranks second among...
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Impact of a CMAM Intervention on Demand for Other Primary Health Care Services in Katsina State, Nigeria
Azeez Afebu Oseni,
Wale Falade
Issue:
Volume 9, Issue 5, October 2021
Pages:
248-253
Received:
1 September 2021
Accepted:
9 October 2021
Published:
19 October 2021
Abstract: Malnutrition in both acute and chronic forms is a global issue responsible for as much as 50% of infant mortality worldwide. Acute malnutrition exists as both moderate and severe forms depending on factors such as access to nutritious meals and maternal care practices. Moderate Acute Malnutrition (MAM) can be easily treated and has lesser mortality impacts compared to Severe Acute Malnutrition (SAM). Community Management of Acute Malnutrition (CMAM) is a community-based approach to addressing SAM and MAM. In this study, the impact of a donor funded CMAM intervention delivered through primary healthcare (PHC) facilities in Katsina state, Nigeria is measured. Prior to this study, there was low utilization of these facilities due to the several factors such as transportation and communication problems, traditional conservatism, poor quality of services, and low literacy rates. A randomised sampling method was used to select and compare 5 CMAM and 5 non-CMAM facilities across the state. A test for significance for two independent groups (CMAM supported and non-CMAM supported sites) was also conducted for different categories of admissions such as antenatal care (ANC), outpatient department (OPD) and routine immunization (RI). From the result, it is concluded that the CMAM intervention increased the rate of patient access and use of PHCs within the state. The test of significance also shows significant differences between the admissions for OPD, ANC, and RI when compared to non-CMAM sites.
Abstract: Malnutrition in both acute and chronic forms is a global issue responsible for as much as 50% of infant mortality worldwide. Acute malnutrition exists as both moderate and severe forms depending on factors such as access to nutritious meals and maternal care practices. Moderate Acute Malnutrition (MAM) can be easily treated and has lesser mortality...
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Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat
Touzani Asmae,
Tahri Joutei Abderrafie,
Khaliss Hajar,
Dami Abdellah,
Balouch Lhousaine,
Kriouile Yamna,
Zineb Imane,
Gaouzi Ahmed
Issue:
Volume 9, Issue 5, October 2021
Pages:
254-258
Received:
13 September 2021
Accepted:
4 October 2021
Published:
19 October 2021
Abstract: Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.
Abstract: Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that v...
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Effectiveness and Tolerability of the ASAQ versus AL Association in Children 6-59 Months for the Treatment of Uncomplicated P. falciparum Malaria in Massakory (Chad)
Mahamat Moussa Hassane Taïsso,
Issa Mahamat Souleymane,
Hamit Mahamat Alio,
Mahamat Saleh Issakha Diar,
Djiddi Ali Sougoudi,
Djimadoum Mbanga,
Pascal Ringwald,
Djimrassengarh Honoré,
Issa Ali Haggar,
Hassoumi Manah,
Hassan Ahmat Mihedi,
N’garadoum Olivier,
David Koffi,
Offianan André Touré,
Djaman Allico Joseph
Issue:
Volume 9, Issue 5, October 2021
Pages:
259-266
Received:
23 September 2021
Accepted:
13 October 2021
Published:
21 October 2021
Abstract: Background and Objective: Artemisinin-based combination therapies are the first-line antimalarial drugs used to treat uncomplicated Plasmodium falciparum malaria in many endemic countries worldwide. This study was conducted to assess the efficacy and tolerability of two fixed-dose formulations of artesunate-amodiaquine and artemether-lumefantrine for the treatment of Plasmodium falciparum malaria in Chad. Méthodology and Results: A two-arm single cohort study was conducted assessing the efficacy artesunate-amodiaquine and artemether-lumefantrine for the treatment of children with uncomplicated falciparum malaria. This study was carried out from December 14, 2019 to March 14, 2020 at the Massakory I Health Center in Chad. Primary efficacy endpoint was day 28, parasitological cure rate. Secondary endpoints were parasite and fever clearance times and tolerability. A total of 113 patients were included, including 56 in the artesunate-amodiaquine arm and 57 in the artemether-lumefantrine arm. In intention to treat these patients, the Adequate Clinical and Parasitological Response on day 28 were 100% for the two groups. No early treatment failure was observed. The drugs were well tolerated and no serious adverse events were noted. Conclusion: Both forms of Artemisinin-based combination therapy were still effective and safe in the treatment of uncomplicated P. falciparum malaria in Chad. Further studies are warranted in different regions of Chad for monitoring of drug resistance.
Abstract: Background and Objective: Artemisinin-based combination therapies are the first-line antimalarial drugs used to treat uncomplicated Plasmodium falciparum malaria in many endemic countries worldwide. This study was conducted to assess the efficacy and tolerability of two fixed-dose formulations of artesunate-amodiaquine and artemether-lumefantrine f...
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Co-relation Between Perinatal Asphyxia with Hypoxic Ischemic Encephalopathy (PNA with HIE) and Blood Sugar Level
Abdul Hakim,
Mahmuder Rahman,
Morium Begum
Issue:
Volume 9, Issue 5, October 2021
Pages:
267-270
Received:
4 March 2021
Accepted:
2 August 2021
Published:
28 October 2021
Abstract: Introduction: Perinatal asphyxia is one of the most common primary causes of mortality and morbidity among neonates. Perinatal asphyxia will result in neonatal hypoxia and tissue/organ injury. Objective: The aim of this study was to observe the Co-relation between Perinatal asphyxia with Hypoxic Ischemic Encephalopathy (PNA with HIE) and Blood sugar level. Methodology: This is a descriptive cross-sectional case study where a total of 182 neonates were admitted to the hospital with the problem of Perinatal asphyxia with Hypoxic Ischemic Encephalopathy and with some other associated problem. Result: Among the cases, 114 (62.6%) were Boys and 68 (37.45%) Girls. The mean age was 29.72 ± 78.42, Weight 2.77 ± .60, RBS 6.57 ± 7.38. Among the asphyxiated neonates blood sugar levels in arterial cord blood were significantly lower and had a negative (r=−0.195, P<0.01) correlation with the severity of birth asphyxia and different stages of HIE. Conclusion: Perinatal asphyxia can result in neonatal hypoxia and tissue/organ injury. A variety of maternal, obstetric, and neonatal conditions predispose the fetus and newborn to asphyxia, which can occur before, during, or after birth From our result, we can conclude that the relationship between Perinatal asphyxia and blood sugar level is significantly lower and negative.
Abstract: Introduction: Perinatal asphyxia is one of the most common primary causes of mortality and morbidity among neonates. Perinatal asphyxia will result in neonatal hypoxia and tissue/organ injury. Objective: The aim of this study was to observe the Co-relation between Perinatal asphyxia with Hypoxic Ischemic Encephalopathy (PNA with HIE) and Blood suga...
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The Place of X-ray Endovascular Catheter Technologies Taking into Account Errors in the Diagnostic and Treatment Algorithm of Patients with Mediastinal Tumors
Kravchenko Roman Yuriyovych,
Avdosyev Yuriy Volodymyrovych,
Oleh Mykolayovych Luzan,
Yakiv Ivanovych Ivashchik
Issue:
Volume 9, Issue 5, October 2021
Pages:
271-278
Received:
26 September 2021
Accepted:
20 October 2021
Published:
30 October 2021
Abstract: The purpose of the study. Increase the effectiveness of treatment of patients with epithelial tumors of the mediastinum by using intra-arterial chemoembolization as a neoadjuvant therapy to create ischemia and high concentrations of cytostatics in tumors for a long period of time to achieve devitalization of tumor tissue and reduce overall toxicity of chemotherapy. Object of study. Epithelial tumors of the thymus gland. Research methods: Clinical, laboratory, morphological, instrumental, statistical. Laboratory tests will include general clinical blood tests, biochemical parameters (ALT, AST, bilirubin, alkaline phosphatase, gammaglutamine transpeptidase, lactate dehydrogenase, albumin), biochemical markers of thymus tumor (AFP, HGT), acetylcholine. General blood test (hemoglobin, erythrocytes, leukocytes, platelets). Instrumental methods of examination will include CT (computed tomography) with intravenous contrast, MRI (magnetic resonance imaging). The conclusions can be made from the literature review. It can be stated that there is no common view on the diagnosis and choice of treatment tactics for patients with epithelial tumors of the thymus. Histological heterogeneity of tumors of this anatomical region with the similarity of clinical manifestations and radiological symptoms requires the development of algorithms for their differential diagnosis and optimization of treatment. In addition, over the last decade in Ukraine there has been a significant increase in the number of mediastinal tumors, especially the thymus gland. Given mainly the young age of patients with this disease and the high degree of aggressiveness of the disease, the problem is transformed to the social level. It is also necessary to review the traditional approach to the treatment of this pathology, the first link of which is considered to be surgery.
Abstract: The purpose of the study. Increase the effectiveness of treatment of patients with epithelial tumors of the mediastinum by using intra-arterial chemoembolization as a neoadjuvant therapy to create ischemia and high concentrations of cytostatics in tumors for a long period of time to achieve devitalization of tumor tissue and reduce overall toxicity...
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Deep Learning Technology-based Model to Identify Benign and Pro-B Acute Lymphoblastic Leukemia (ALL): Xception + LIME
Issue:
Volume 9, Issue 5, October 2021
Pages:
279-285
Received:
8 October 2021
Accepted:
27 October 2021
Published:
30 October 2021
Abstract: Leukemia is a type of cancer that occurs when abnormal blood cells take place in the bone marrow. Leukemia can either be acute (fastly growing) or chronic (slowly growing) and it is considered as one of the most commonly diagnosed cancers for children younger than the age of 15 or adults older than the age of 55. Leukemia can be diagnosed through various types of tests and depending on the aggressiveness of the disease, the treatment may differ. To provide a low-cost, time-efficient solution, this study employs the deep learning technique to train the Xception, VGG16, VGG19, and MobileNet models to optimize the accuracy of medical image detection. Through medical imaging, the trained model is able to detect anomalies in the dataset and identify whether the given data is a benign acute lymphoblastic leukemia (ALL) or a Pro-B ALL. Overall, this VGG16 showed the most optimal performance in terms of accuracy and precision, producing a 98.5% accuracy in detecting abnormal regions from the dataset. This study also further used XAI technique and a deep convolutional neural network to visualize the results of anomalies. As a result, this paper concluded that both deep learning and machine learning techniques are yet to replace human resources and intelligence as the heatmap and the LIME portrayal identified different regions as abnormal parts, therefore proving the inconsistency of deep learning technology.
Abstract: Leukemia is a type of cancer that occurs when abnormal blood cells take place in the bone marrow. Leukemia can either be acute (fastly growing) or chronic (slowly growing) and it is considered as one of the most commonly diagnosed cancers for children younger than the age of 15 or adults older than the age of 55. Leukemia can be diagnosed through v...
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Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI
Fu Xianzhao,
Jiang Xiaofeng,
Chen Jiajun,
Cen Qianli,
Li Yuegui,
Qiu Haixian
Issue:
Volume 9, Issue 5, October 2021
Pages:
286-291
Received:
2 October 2021
Accepted:
26 October 2021
Published:
5 November 2021
Abstract: Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (P<0.05). Serum inflammatory mediators (CRP, IL-6, TNF-α) and Ang II decreased more than that in the control group (all P<0.05); And in treatment group, the left ventricular morphology index (LVESD, LVEDD) decreased more than that in the control group, while the cardiac function indexes (∆ FS, CO, CI, SV, LVEF, E/A) were increased more in treatment group. Conclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.
Abstract: Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were eq...
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