Review Article
Factor V Leiden (G1691A), Prothrombin (G20210A) and MTHFR (C677T) Mutations in Yemeni Subjects Tested for Thrombophilia
Issue:
Volume 13, Issue 3, June 2025
Pages:
131-138
Received:
8 January 2025
Accepted:
12 March 2025
Published:
24 May 2025
Abstract: The Factor V Leiden (G1691A), Prothrombin gene (G20210A) and MTHFR (C677T) mutations are the significant biomarkers for evaluation of tendency for venous thrombosis. The objective of our study was to assess the frequency of factor V Leiden (G1691A), Prothrombin (G20210A) and MTHFR (C677T) variants in Yemeni subjects tested for thrombophilia. Methods: Our study included 441 thrombophilia subjects (138 subjects for FVL (G1691A) mutation, 164 subjects for PT (G20210A) mutation and 139 for MTHFR (C677T) mutation) who were genotyped by method of SNP Genotyping Assay (FVL, PT and MTHFR variants Real Time PCR Kits), and the allele frequencies of factor V Leiden (G1691A), prothrombin (G20210A), and MTHFR (C677T) mutations were calculated. The laboratory data of patients tested were reviewed and analyzed in the Aulaqi specialized medical laboratories. Results: Factor V Leiden (G1691A) mutation was present in 10% of all subjects (heterozygotes: 10%, homozygotes mutant: 0%). Prothrombin (G20210A) mutation was found in 8.5% of subjects (heterozygotes: 7.3%, homozygotes mutant: 1.2%) and MTHFR (C677T) mutation in 39.5% of subjects (heterozygotes: 34.5%, homozygotes mutant: 5%). Conclusion: This study reports high prevalence of FVL (G1691A), PT (G20210A) and MTHFR (C677T) mutations among subjects with thrombophilia. Consequently, genotyping assay for of the three thrombotic gene mutations have a priority in the evaluation of subjects with thrombophilia, as well as in the screening for additional clinical conditions correlated with an elevated risk of thrombosis in Sana'a city-Yemen.
Abstract: The Factor V Leiden (G1691A), Prothrombin gene (G20210A) and MTHFR (C677T) mutations are the significant biomarkers for evaluation of tendency for venous thrombosis. The objective of our study was to assess the frequency of factor V Leiden (G1691A), Prothrombin (G20210A) and MTHFR (C677T) variants in Yemeni subjects tested for thrombophilia. Method...
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Research Article
Evaluating the Effectiveness of One Stop Crisis Centre in Responding to Gender-Based Violence in Bangladesh
Shanta Saha
,
Alahi Khandaker*,
Anupam Saha,
Rumana Yasmin Ferdausi
Issue:
Volume 13, Issue 3, June 2025
Pages:
139-144
Received:
18 April 2025
Accepted:
24 April 2025
Published:
29 May 2025
Abstract: Background: Gender-based violence represents a critical challenge in Bangladesh, with one-stop crisis center serving as essential facilities for survivors seeking medical care, legal aid, and psychosocial support. Limited comprehensive data exists on victim profiles, violence characteristics, and service effectiveness at these centers, particularly in urban settings like Chittagong. Objective: This study aimed to evaluate the effectiveness of one stop crisis centres in responding to gender-based violence in Bangladesh. Methods: We conducted a hospital-based cross-sectional study of 124 GBV victims at the One-stop Crisis Center (OCC), Chittagong Medical College Hospital, Bangladesh. Data collection included structured interviews and medical record reviews, with analysis performed using SPSS version 23.0. Statistical methods included descriptive analyses, chi-square tests, linear regression, and t-tests. Results: The study revealed 46.8% of victims were aged 20-29 years, with 91.9% female. Physical assault by husbands (22.6% dowry-related) and sexual assault by neighbors (17.7%) were predominant. While 68.5% strongly endorsed medical care, legal/financial support showed lower satisfaction (25.8% neutral). Married victims reported higher satisfaction than unmarried (p=0.015). Education level showed no significant association with injury type (χ²=3.82, p=0.28). However, higher education predicted greater satisfaction with legal support (β=0.28, p=0.012). These findings highlight important relationships between victim characteristics and service experiences. Conclusion: This study reveals critical gaps in Bangladesh's GBV response, particularly in legal and financial support services. While medical care was effective, comprehensive reforms are needed to address socioeconomic vulnerabilities and ensure equitable services for all victims, especially unmarried women and adolescents. Integrated, victim-centered approaches remain essential.
Abstract: Background: Gender-based violence represents a critical challenge in Bangladesh, with one-stop crisis center serving as essential facilities for survivors seeking medical care, legal aid, and psychosocial support. Limited comprehensive data exists on victim profiles, violence characteristics, and service effectiveness at these centers, particularly...
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Research Article
Study on Functional Outcome of VDRO in Late-Presenting Perthes Disease in Paediatric
Mohammad Asaduzzaman*,
Quazi Shahid-ul Alam
Issue:
Volume 13, Issue 3, June 2025
Pages:
145-150
Received:
23 April 2025
Accepted:
6 May 2025
Published:
6 June 2025
DOI:
10.11648/j.ajhr.20251303.13
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Abstract: Background: Perthes disease is a pediatric hip disorder characterized by avascular necrosis of the femoral head, with late presentation (after age seven) often associated with poor prognosis and controversy over optimal management. This study aims to assess the functional outcomes of varus derotation osteotomy (VDRO) in children with late-presenting Perthes disease. Aim of the study: The aim of the study was to evaluate the functional outcomes of Varus Derotation Osteotomy (VDRO) in paediatric patients with late-presenting Perthes disease. Methods: This prospective study at the Department of Orthopaedics, Sylhet MAG Osmani Medical College Hospital (2023-24) evaluated VDRO in 14 children (8-12 years) with unilateral Perthes (Herring B/C). Patients underwent subtrochanteric osteotomy (15-20° varus correction, DCP fixation) followed by 6-week spica casting. Functional outcomes were assessed using Harris Hip Score over 6 months. Data were analyzed using SPSS v25. Results: This study included 14 paediatric patients with late-presenting Perthes disease treated by VDRO. Most were aged 8–10 years (64.29%) and male (71.00%), with right-side involvement in 57.14%. Based on the modified Elizabethtown classification, Stage I B was most common, and 57.14% were classified as Herring’s Group B. Postoperatively, 57.14% had excellent to good outcomes per Harris Hip Score, while complications were minimal, with hypertrophic scar being the most frequent. Conclusion: VDRO is an effective treatment for late-presenting LCPD in adolescents, yielding favorable functional outcomes and manageable complications.
Abstract: Background: Perthes disease is a pediatric hip disorder characterized by avascular necrosis of the femoral head, with late presentation (after age seven) often associated with poor prognosis and controversy over optimal management. This study aims to assess the functional outcomes of varus derotation osteotomy (VDRO) in children with late-presentin...
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