Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance

Xiaosheng Chen; Zhenyu Yang; Qingqi Meng; Siming Li

doi:doi:10.11648/j.ijcems.20220805.14

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Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance

Xiaosheng Chen, Zhenyu Yang, Qingqi Meng, Siming Li

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 8, Issue 5)

Received: 28 August 2022 Accepted: 12 September 2022 Published: 27 September 2022

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Abstract

Osteoarthritis is a chronic inflammatory joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling, and its development may be influenced by multiple factors such as genetics, environment, metabolism, and mechanical stress, with a complex pathogenesis. Clinically, osteoarthritis seriously affects the life of patients with clinical manifestations such as pain, swelling, and joint movement disorders. With the aggravation of the aging population in China, patients with osteoarthritis are on the rise. Therefore, the study of OA pathological mechanism has drawn much more concerns. Pyroptosis is a proinflammatory programmed cell necrosis mediated by inflammasomes that depends on Gasdermin family proteins and it is closely related to the development and progression of a variety of diseases. Statistics showed that pyroptosis plays an important role in the development and progression of osteoarthritis. By reviewing the latest research on the molecular mechanism of pyroptosis and its effect in treating osteoarthritis, the important role of pyroptosis activation pathway in the process of osteoarthritis is revealed, focusing on the related signaling molecules, signaling pathways, targets of pyroptosis, and targeted drugs that inhibit pyroptosis. It provides new ideas for the mechanism study of osteoarthritis and also new targets for the treatment of osteoarthritis.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 8, Issue 5)
DOI	10.11648/j.ijcems.20220805.14
Page(s)	73-77
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Pyroptosis, Osteoarthritis, Caspase-1, NLRP3, Gasdermin-D, IL-1β

References

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APA Style

Xiaosheng Chen, Zhenyu Yang, Qingqi Meng, Siming Li. (2022). Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance. International Journal of Clinical and Experimental Medical Sciences, 8(5), 73-77. https://doi.org/10.11648/j.ijcems.20220805.14

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ACS Style

Xiaosheng Chen; Zhenyu Yang; Qingqi Meng; Siming Li. Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance. Int. J. Clin. Exp. Med. Sci. 2022, 8(5), 73-77. doi: 10.11648/j.ijcems.20220805.14

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AMA Style

Xiaosheng Chen, Zhenyu Yang, Qingqi Meng, Siming Li. Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance. Int J Clin Exp Med Sci. 2022;8(5):73-77. doi: 10.11648/j.ijcems.20220805.14

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@article{10.11648/j.ijcems.20220805.14,
  author = {Xiaosheng Chen and Zhenyu Yang and Qingqi Meng and Siming Li},
  title = {Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {8},
  number = {5},
  pages = {73-77},
  doi = {10.11648/j.ijcems.20220805.14},
  url = {https://doi.org/10.11648/j.ijcems.20220805.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20220805.14},
  abstract = {Osteoarthritis is a chronic inflammatory joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling, and its development may be influenced by multiple factors such as genetics, environment, metabolism, and mechanical stress, with a complex pathogenesis. Clinically, osteoarthritis seriously affects the life of patients with clinical manifestations such as pain, swelling, and joint movement disorders. With the aggravation of the aging population in China, patients with osteoarthritis are on the rise. Therefore, the study of OA pathological mechanism has drawn much more concerns. Pyroptosis is a proinflammatory programmed cell necrosis mediated by inflammasomes that depends on Gasdermin family proteins and it is closely related to the development and progression of a variety of diseases. Statistics showed that pyroptosis plays an important role in the development and progression of osteoarthritis. By reviewing the latest research on the molecular mechanism of pyroptosis and its effect in treating osteoarthritis, the important role of pyroptosis activation pathway in the process of osteoarthritis is revealed, focusing on the related signaling molecules, signaling pathways, targets of pyroptosis, and targeted drugs that inhibit pyroptosis. It provides new ideas for the mechanism study of osteoarthritis and also new targets for the treatment of osteoarthritis.},
 year = {2022}
}

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TY  - JOUR
T1  - Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance
AU  - Xiaosheng Chen
AU  - Zhenyu Yang
AU  - Qingqi Meng
AU  - Siming Li
Y1  - 2022/09/27
PY  - 2022
N1  - https://doi.org/10.11648/j.ijcems.20220805.14
DO  - 10.11648/j.ijcems.20220805.14
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 73
EP  - 77
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20220805.14
AB  - Osteoarthritis is a chronic inflammatory joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling, and its development may be influenced by multiple factors such as genetics, environment, metabolism, and mechanical stress, with a complex pathogenesis. Clinically, osteoarthritis seriously affects the life of patients with clinical manifestations such as pain, swelling, and joint movement disorders. With the aggravation of the aging population in China, patients with osteoarthritis are on the rise. Therefore, the study of OA pathological mechanism has drawn much more concerns. Pyroptosis is a proinflammatory programmed cell necrosis mediated by inflammasomes that depends on Gasdermin family proteins and it is closely related to the development and progression of a variety of diseases. Statistics showed that pyroptosis plays an important role in the development and progression of osteoarthritis. By reviewing the latest research on the molecular mechanism of pyroptosis and its effect in treating osteoarthritis, the important role of pyroptosis activation pathway in the process of osteoarthritis is revealed, focusing on the related signaling molecules, signaling pathways, targets of pyroptosis, and targeted drugs that inhibit pyroptosis. It provides new ideas for the mechanism study of osteoarthritis and also new targets for the treatment of osteoarthritis.
VL  - 8
IS  - 5
ER  -

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Author Information

Xiaosheng Chen

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Zhenyu Yang

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Qingqi Meng

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Siming Li

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China

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APA Style

Xiaosheng Chen, Zhenyu Yang, Qingqi Meng, Siming Li. (2022). Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance. International Journal of Clinical and Experimental Medical Sciences, 8(5), 73-77. https://doi.org/10.11648/j.ijcems.20220805.14

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ACS Style

Xiaosheng Chen; Zhenyu Yang; Qingqi Meng; Siming Li. Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance. Int. J. Clin. Exp. Med. Sci. 2022, 8(5), 73-77. doi: 10.11648/j.ijcems.20220805.14

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AMA Style

Xiaosheng Chen, Zhenyu Yang, Qingqi Meng, Siming Li. Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance. Int J Clin Exp Med Sci. 2022;8(5):73-77. doi: 10.11648/j.ijcems.20220805.14

Copy | Download

@article{10.11648/j.ijcems.20220805.14,
  author = {Xiaosheng Chen and Zhenyu Yang and Qingqi Meng and Siming Li},
  title = {Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {8},
  number = {5},
  pages = {73-77},
  doi = {10.11648/j.ijcems.20220805.14},
  url = {https://doi.org/10.11648/j.ijcems.20220805.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20220805.14},
  abstract = {Osteoarthritis is a chronic inflammatory joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling, and its development may be influenced by multiple factors such as genetics, environment, metabolism, and mechanical stress, with a complex pathogenesis. Clinically, osteoarthritis seriously affects the life of patients with clinical manifestations such as pain, swelling, and joint movement disorders. With the aggravation of the aging population in China, patients with osteoarthritis are on the rise. Therefore, the study of OA pathological mechanism has drawn much more concerns. Pyroptosis is a proinflammatory programmed cell necrosis mediated by inflammasomes that depends on Gasdermin family proteins and it is closely related to the development and progression of a variety of diseases. Statistics showed that pyroptosis plays an important role in the development and progression of osteoarthritis. By reviewing the latest research on the molecular mechanism of pyroptosis and its effect in treating osteoarthritis, the important role of pyroptosis activation pathway in the process of osteoarthritis is revealed, focusing on the related signaling molecules, signaling pathways, targets of pyroptosis, and targeted drugs that inhibit pyroptosis. It provides new ideas for the mechanism study of osteoarthritis and also new targets for the treatment of osteoarthritis.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance
AU  - Xiaosheng Chen
AU  - Zhenyu Yang
AU  - Qingqi Meng
AU  - Siming Li
Y1  - 2022/09/27
PY  - 2022
N1  - https://doi.org/10.11648/j.ijcems.20220805.14
DO  - 10.11648/j.ijcems.20220805.14
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 73
EP  - 77
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20220805.14
AB  - Osteoarthritis is a chronic inflammatory joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling, and its development may be influenced by multiple factors such as genetics, environment, metabolism, and mechanical stress, with a complex pathogenesis. Clinically, osteoarthritis seriously affects the life of patients with clinical manifestations such as pain, swelling, and joint movement disorders. With the aggravation of the aging population in China, patients with osteoarthritis are on the rise. Therefore, the study of OA pathological mechanism has drawn much more concerns. Pyroptosis is a proinflammatory programmed cell necrosis mediated by inflammasomes that depends on Gasdermin family proteins and it is closely related to the development and progression of a variety of diseases. Statistics showed that pyroptosis plays an important role in the development and progression of osteoarthritis. By reviewing the latest research on the molecular mechanism of pyroptosis and its effect in treating osteoarthritis, the important role of pyroptosis activation pathway in the process of osteoarthritis is revealed, focusing on the related signaling molecules, signaling pathways, targets of pyroptosis, and targeted drugs that inhibit pyroptosis. It provides new ideas for the mechanism study of osteoarthritis and also new targets for the treatment of osteoarthritis.
VL  - 8
IS  - 5
ER  -

Copy | Download