Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province
Zhang Lifu,
Zhang Wei Yu,
Yang Xiujun,
Liu Xin,
Ma Yingcong,
Wang Hui
Issue:
Volume 8, Issue 5, September 2022
Pages:
65-68
Received:
2 August 2022
Accepted:
26 August 2022
Published:
16 September 2022
DOI:
10.11648/j.ijcems.20220805.11
Downloads:
Views:
Abstract: Objective: Through the analysis of drug resistance of 157 strains of multidrug resistant Mycobacterium tuberculosis in Jilin Province, the drug resistance spectrum of multi drug resistant Mycobacterium tuberculosis in Jilin Province was preliminarily established to provide the basis for the treatment of patients with multi drug resistant tuberculosis in the future. Methods: Anti-tuberculosis streptomycin (SM), ethambutol (EMB), of loxacin (OFX) and kanamycin (KM) were tested by L-J ratio. Results: The SM resistance rate in 157 MDR M. tuberculosis strains was 56.05%, EMB The resistance rate 38.85%, OFX The resistance rate 64.97%, KM The resistance rate 14.65%. The XDR resistance rate was 14.01%. The results of drug resistance analysis in different characteristic populations show that second-line drugs OFX and KM drug resistance rates Female patients Higher than male, and statistically significant (P < 0.05), the resistance rate of OFX relapse patients was significantly higher than that in naive patients, and was statistically significant (P < 0.05). Conclusion: The resistance rate of tuberculosis patients in Jilin Province to the first-line and second-line anti-tuberculosis drugs is at a relatively high level, and the situation of tuberculosis prevention and control is not optimistic. The management of patients should be strengthened in the prevention and treatment strategies, and the use of anti-tuberculosis drugs should be standardized, At the same time, strengthen the ability of tuberculosis laboratory to detect drug-resistant Mycobacterium tuberculosis is strengthened.
Abstract: Objective: Through the analysis of drug resistance of 157 strains of multidrug resistant Mycobacterium tuberculosis in Jilin Province, the drug resistance spectrum of multi drug resistant Mycobacterium tuberculosis in Jilin Province was preliminarily established to provide the basis for the treatment of patients with multi drug resistant tuberculos...
Show More
Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum
Zhenyu Yang,
Xiaosheng Chen,
Qingqi Meng
Issue:
Volume 8, Issue 5, September 2022
Pages:
69-72
Received:
2 September 2022
Accepted:
12 September 2022
Published:
27 September 2022
DOI:
10.11648/j.ijcems.20220805.12
Downloads:
Views:
Abstract: Background: Mycobacterium fortuitum complex (MTC) is a group of rapidly growing nontuberculous mycobacteria (NTM) that often develop in immunocompromised patients, while local NTM disease is most common in postoperative wound infections or invasion of the skin from wounds. Clinical case reports are rare, which often lead to tissue abscess and ulceration, and natural resistance to anti-tuberculosis drugs, difficult to control, long treatment process, mostly lasting more than half a year or even a year, and the therapeutic effect is relatively poor. The incidence of NTM-associated infections is increasing and is emerging as a global public health concern. Objective: To introduce the diagnosis and treatment of a case of soft tissue infection caused by Mycobacterium fortuitum in order to improve clinicians' understanding of the disease and deepen the understanding of bacteriological characteristics of the bacterium by microbiological examination personnel. Methods: Bacterial culture was performed in wound secretion, and MRI was performed to examine soft tissue infection. Result: Mass spectrometry analysis of bacterial culture of wound secretion showed Mycobacterium fortuitum infection. MR showed soft tissue infection and sinus formation in the posterolateral aspect of the right ankle. After diagnosis, the antibiotic regimen was adjusted to levofloxacin, amikacin, and rifampicin for triple anti-infection. One month later, the patient was discharged from the hospital for oral treatment with levofloxacin tablets, clarithromycin tablets and rifampicin capsules for 1 year and followed up for 1.5 years without recurrence. Conclusion: This paper can provide reference for etiological diagnosis, identification and treatment of non-tuberculous mycobacteria-related soft tissue infection.
Abstract: Background: Mycobacterium fortuitum complex (MTC) is a group of rapidly growing nontuberculous mycobacteria (NTM) that often develop in immunocompromised patients, while local NTM disease is most common in postoperative wound infections or invasion of the skin from wounds. Clinical case reports are rare, which often lead to tissue abscess and ulcer...
Show More
Role of Pyroptosis in Osteoarthritis and Its Therapeutic Significance
Xiaosheng Chen,
Zhenyu Yang,
Qingqi Meng,
Siming Li
Issue:
Volume 8, Issue 5, September 2022
Pages:
73-77
Received:
28 August 2022
Accepted:
12 September 2022
Published:
27 September 2022
DOI:
10.11648/j.ijcems.20220805.14
Downloads:
Views:
Abstract: Osteoarthritis is a chronic inflammatory joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling, and its development may be influenced by multiple factors such as genetics, environment, metabolism, and mechanical stress, with a complex pathogenesis. Clinically, osteoarthritis seriously affects the life of patients with clinical manifestations such as pain, swelling, and joint movement disorders. With the aggravation of the aging population in China, patients with osteoarthritis are on the rise. Therefore, the study of OA pathological mechanism has drawn much more concerns. Pyroptosis is a proinflammatory programmed cell necrosis mediated by inflammasomes that depends on Gasdermin family proteins and it is closely related to the development and progression of a variety of diseases. Statistics showed that pyroptosis plays an important role in the development and progression of osteoarthritis. By reviewing the latest research on the molecular mechanism of pyroptosis and its effect in treating osteoarthritis, the important role of pyroptosis activation pathway in the process of osteoarthritis is revealed, focusing on the related signaling molecules, signaling pathways, targets of pyroptosis, and targeted drugs that inhibit pyroptosis. It provides new ideas for the mechanism study of osteoarthritis and also new targets for the treatment of osteoarthritis.
Abstract: Osteoarthritis is a chronic inflammatory joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling, and its development may be influenced by multiple factors such as genetics, environment, metabolism, and mechanical stress, with a complex pathogenesis. Clinically, osteoarthritis seriously affects t...
Show More
