@article{10.11648/j.ijde.20220702.14,
  author = {Thierry Razanamparany and Sitraka Angelo Raharinavalona and Haritsiky Robertini Ramalanjaona and Rija Eric Raherison and Miora Maeva Arielle Andrianiaina and Tsikinirina Valisoa Randrianomanana and Fenitrasoa Randrianarizao and Andrianirina Dave Patrick Rakotomalala and Hanta Marie Danielle Vololontiana and Radonirina Lazasoa Andrianasolo},
  title = {Determining Factors of Mortality by Ketoacidosis as Seen in the Unit of Endocrinology at Joseph Raseta Befelatanana Teaching Hospital, Antananarivo-Madagascar},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {7},
  number = {2},
  pages = {43-49},
  doi = {10.11648/j.ijde.20220702.14},
  url = {https://doi.org/10.11648/j.ijde.20220702.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220702.14},
  abstract = {Introduction: Ketoacidosis is one of the acute metabolic complications of diabetes. It is more common and has a higher death rate in sub-Saharan Africa. To our knowledge, there are very few studies done on diabetic ketoacidosis in Madagascar. The aim of our study was to determine the hospital prevalence of diabetic ketoacidosis, to describe their epidemioclinical features as well as to look for determinants of hospital mortality in patients with ketoacidosis in the unit of endocrinology at Joseph Raseta Befelatanana University Hospital, Antananarivo. Methods: This is a descriptive retrospective study of diabetics admitted to this unit for ketoacidosis, over a period of 15 months (from January 1, 2017, to March 30, 2018). Results: Sixty-four patients were selected for the study. The hospital prevalence of ketoacidosis was 5.61%. The mean age of the patients was 46.3 years with a sex ratio of 0.94. Type 2 diabetes predominated in terms of frequency (62.5%). In 37.5% of cases, ketoacidosis was the inaugural diabetes. For patients known to be diabetic before admission, infection was the most common etiologic factor (48.44%), followed by discontinuation of treatment (31.25%). The death rate was 3.13%. Epidemioclinical variables: age [50-60 years], disturbance of consciousness, Glasgow scale  500 mg/dl, hyperkalaemia and ketonuria at 4+ at entry are determinants of mortality. Conclusion: Ketoacidosis exposes people to mortality, the rate of which is not negligible. There are determinants of hospital mortality from this complication of diabetes. The therapeutic education of patients and the improvement of screening tools are very important for prevention.},
 year = {2022}
}

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TY  - JOUR
T1  - Determining Factors of Mortality by Ketoacidosis as Seen in the Unit of Endocrinology at Joseph Raseta Befelatanana Teaching Hospital, Antananarivo-Madagascar
AU  - Thierry Razanamparany
AU  - Sitraka Angelo Raharinavalona
AU  - Haritsiky Robertini Ramalanjaona
AU  - Rija Eric Raherison
AU  - Miora Maeva Arielle Andrianiaina
AU  - Tsikinirina Valisoa Randrianomanana
AU  - Fenitrasoa Randrianarizao
AU  - Andrianirina Dave Patrick Rakotomalala
AU  - Hanta Marie Danielle Vololontiana
AU  - Radonirina Lazasoa Andrianasolo
Y1  - 2022/06/30
PY  - 2022
N1  - https://doi.org/10.11648/j.ijde.20220702.14
DO  - 10.11648/j.ijde.20220702.14
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 43
EP  - 49
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20220702.14
AB  - Introduction: Ketoacidosis is one of the acute metabolic complications of diabetes. It is more common and has a higher death rate in sub-Saharan Africa. To our knowledge, there are very few studies done on diabetic ketoacidosis in Madagascar. The aim of our study was to determine the hospital prevalence of diabetic ketoacidosis, to describe their epidemioclinical features as well as to look for determinants of hospital mortality in patients with ketoacidosis in the unit of endocrinology at Joseph Raseta Befelatanana University Hospital, Antananarivo. Methods: This is a descriptive retrospective study of diabetics admitted to this unit for ketoacidosis, over a period of 15 months (from January 1, 2017, to March 30, 2018). Results: Sixty-four patients were selected for the study. The hospital prevalence of ketoacidosis was 5.61%. The mean age of the patients was 46.3 years with a sex ratio of 0.94. Type 2 diabetes predominated in terms of frequency (62.5%). In 37.5% of cases, ketoacidosis was the inaugural diabetes. For patients known to be diabetic before admission, infection was the most common etiologic factor (48.44%), followed by discontinuation of treatment (31.25%). The death rate was 3.13%. Epidemioclinical variables: age [50-60 years], disturbance of consciousness, Glasgow scale  500 mg/dl, hyperkalaemia and ketonuria at 4+ at entry are determinants of mortality. Conclusion: Ketoacidosis exposes people to mortality, the rate of which is not negligible. There are determinants of hospital mortality from this complication of diabetes. The therapeutic education of patients and the improvement of screening tools are very important for prevention.
VL  - 7
IS  - 2
ER  - 

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