Background: Diabetes mellitus is a chronic disease caused by endocrine metabolic disorders, which has developed into a global public health problem. Currently, the number of people with diabetes has reached approximately 425 million worldwide. It is estimated that the prevalence of diabetes will increase by 48% by 2045. Genistein, a naturally occurring phytoestrogen found mainly in soybeans, is of great importance in the prevention of many diseases, including tumors and cardiovascular disease. Previous studies have shown that dietary supplementation with phytoestrogens can prevent atherosclerosis. Objective: To describe the mechanism and current status of the effect of genistein on diabetic cardiovascular complications, with the aim of improving the prognosis of patients with diabetic combined cardiovascular complications. Methods: To show the specific value of genistein in diabetic cardiovascular complications by elaborating the biochemical properties of genistein and using the interaction of genistein with vascular endothelium, platelet aggregation, lipid deposition, and inflammation as a starting point. Conclusion: The biological properties and mechanism of action of genistein can provide more references for the prevention and treatment of cardiovascular complications in clinical work.
| Published in | International Journal of Diabetes and Endocrinology (Volume 7, Issue 3) |
| DOI | 10.11648/j.ijde.20220703.11 |
| Page(s) | 50-53 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Genistein, Diabetes, Cardiovascular, Mechanism
| [1] | Ma, R., Epidemiology of diabetes and diabetic complications in China. Diabetologia, 2018. 61 (6): p. 1249-1260. |
| [2] | Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2013 Edition). Chinese Journal of Diabetes, 2014. 6 (07): 447-498. |
| [3] | Weng L, Zhang F, Wang R, et al. A review on protective role of genistein against oxidative stress in diabetes and related complications [J]. Chem Biol Interact, 2019, 310: 108665. |
| [4] | Ali F, Rahul, Naz F, et al. Protective effect of Genistein against N-nitrosodiethylamine (NDEA) hepatotoxicity in Swiss albino rats [J]. J Pharm Anal, 2015, 5 (1): 51-57. |
| [5] | Zhang L, Gao M, Zhang T, et al. Protective Effects of Genistein against Mono- (2-hexyl) Phthalate-Induced Oxidative Damage in Prepubertal Sertoli Cells [J]. Biomed Res Int, 2017, 2017: 2032697. |
| [6] | Chen C, Zheng H, Qi S. Genistein and Silicon Synergistic Protects Against Ovariectomy-Induced Bone Loss Through Upregulating OPG/RANKL Ratio [J]. Biol Trace Elem Res, 2019, 188 (2): 441-450. |
| [7] | Xi Y D, Yu H L, Ma W W, et al. Genistein inhibits mitochondrial-targeted oxidative damage induced by beta-amyloid peptide 25-35 in PC12 cells [J]. J Bioenerg Biomet, 2011, 43 (4): 399-407. |
| [8] | Lei X W, Li Q, Zhang J Z, et al. The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress [J]. Ophthalmic Res, 2019, 62 (2): 80-92. |
| [9] | Li X, Ke X, Li Z, et al. Vaspin prevents myocardial injury in rats model of diabetic cardiomyopathy by enhancing autophagy and inhibiting inflammation [J]. Biochem Biophys Res Commun, 2019, 514 (1): 1-8. |
| [10] | Zhang H P, Zheng F L, Zhao J H, et al. Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1 [J]. Arch Med Res, 2013, 44 (1): 13-20. |
| [11] | Liu M, Wang G, Xu R, et al. Soy Isoflavones Inhibit Both GPIb-IX Signaling and alphaIIbbeta3 Outside-In Signaling via 14-3-3zeta in Platelet [J]. Molecules, 2021, 26 (16). |
| [12] | Kondo K, Suzuki Y, Ikeda Y, et al. Genistein, an isoflavone included in soy, inhibits thrombotic vessel aggregation in the mouse femoral artery and in vitro platelet occlusion [J]. Eur J Pharmacol, 2002, 455 (1): 53-57. |
| [13] | Cyr A R, Huckaby L V, Shiva S S, et al. Nitric Oxide and Endothelial Dysfunction [J]. Crit Care Clin, 2020, 36 (2): 307-321. |
| [14] | Polini N, Rauschemberger M B, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation [J]. Mol Cell Endocrinol, 2007, 267 (1-2): 55-62. |
| [15] | Luksha L, Agewall S, Kublickiene K. Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease [J]. Atherosclerosis, 2009, 202 (2): 330-344. |
| [16] | Amerizadeh A, Asgary S, Vaseghi G, et al. Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis [J]. Curr Probl Cardiol, 2021: 100902. |
| [17] | Guo Y, Wu G, Su X, et al. Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet [J]. Nutr Res, 2009, 29 (9): 656-663. |
| [18] | Haines C, James A, Sahota D, et al. Comparison between phytoestrogens and estradiol in the prevention of atheroma in ovariectomized cholesterol-fed rabbits [J]. Climacteric, 2006, 9 (6): 430-436. |
| [19] | Relic B, Zeddou M, Desoroux A, et al. Genistein adipogenesis but leptin induces apoptosis in human synovial fibroblasts [J]. Lab Invest, 2009, 89 (7): 811-822. |
| [20] | Trompezinski S, Denis A, Schmitt D, et al. Comparative effects of polyphenols from green tea (EGCG) and proinflammatory cytokines (genistein) on VEGF and IL-8 release from normal human keratinocytes stimulated with the cytokine TNFalpha [J]. Arch Dermatol Res, 2003, 295 (3): 112-116. |
| [21] | Gottstein N, Ewins B A, Eccleston C, et al. Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function [J]. Br J Nutr, 2003, 89 (5): 607-616. |
| [22] | Lee Y W, Lee W H. Protective effects of genistein on proinflammatory pathways in human brain microvascular endothelial cells [J]. J Nutr Biochem, 2008, 19 (12): 819-825. |
| [23] | Sandoval M J, Cutini P H, Rauschemberger M B, et al. The soyabean isoflavone genistein modulates endothelial cell behaviour [J]. Br J Nutr, 2010, 104 (2): 171-179. |
| [24] | Dharmappa K K K, Mohamed R, Shivaprasad H V, et al. Genistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation [J]. Inflammopharmacology, 2010, 18 (1): 25-31. |
| [25] | Wing L Y, Chen Y C, Shih Y Y, et al. Effects of oral estrogen on aortic ROS-generating and -scavenging enzymes and atherosclerosis in apoE-deficient mice [J]. Exp Biol Med (Maywood), 2009, 234 (9): 1037-1046. |
| [26] | Exner M, Hermann M, Hofbauer R, et al. Genistein prevents the glucose autogenic oxidation mediated modification of low density lipoprotein [J]. Free Radic Res, 2001, 34 (1): 101-112. |
| [27] | Xu S Z, Zhong W, Ghavideldarestani M, et al. Multiple mechanisms of soy isoflavones against oxidative stress-induced endothelial injury [J]. Free Radic Biol Med, 2009, 47 (2): 167-175. |
| [28] | Vera R, Galisteo M, Villar I C, et al. Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric-oxide synthase, metabolites, and cyclooxygenase [J]. J Pharmacol Exp Ther, 2005, 314 (3): 1300-1309. |
| [29] | Mizutani K, Ikeda K, Nishikata T, et al. Phytoestrogens attenuate oxidative DNA damage in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats [J]. J Hypertens, 2000, 18 (12): 1833-1840. |
APA Style
Na Li, Guomin Yang, Ying Pan, Yu Zhao. (2022). Effect of Genistein on Diabetic Cardiovascular Complications. International Journal of Diabetes and Endocrinology, 7(3), 50-53. https://doi.org/10.11648/j.ijde.20220703.11
ACS Style
Na Li; Guomin Yang; Ying Pan; Yu Zhao. Effect of Genistein on Diabetic Cardiovascular Complications. Int. J. Diabetes Endocrinol. 2022, 7(3), 50-53. doi: 10.11648/j.ijde.20220703.11
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Download@article{10.11648/j.ijde.20220703.11,
author = {Na Li and Guomin Yang and Ying Pan and Yu Zhao},
title = {Effect of Genistein on Diabetic Cardiovascular Complications},
journal = {International Journal of Diabetes and Endocrinology},
volume = {7},
number = {3},
pages = {50-53},
doi = {10.11648/j.ijde.20220703.11},
url = {https://doi.org/10.11648/j.ijde.20220703.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220703.11},
abstract = {Background: Diabetes mellitus is a chronic disease caused by endocrine metabolic disorders, which has developed into a global public health problem. Currently, the number of people with diabetes has reached approximately 425 million worldwide. It is estimated that the prevalence of diabetes will increase by 48% by 2045. Genistein, a naturally occurring phytoestrogen found mainly in soybeans, is of great importance in the prevention of many diseases, including tumors and cardiovascular disease. Previous studies have shown that dietary supplementation with phytoestrogens can prevent atherosclerosis. Objective: To describe the mechanism and current status of the effect of genistein on diabetic cardiovascular complications, with the aim of improving the prognosis of patients with diabetic combined cardiovascular complications. Methods: To show the specific value of genistein in diabetic cardiovascular complications by elaborating the biochemical properties of genistein and using the interaction of genistein with vascular endothelium, platelet aggregation, lipid deposition, and inflammation as a starting point. Conclusion: The biological properties and mechanism of action of genistein can provide more references for the prevention and treatment of cardiovascular complications in clinical work.},
year = {2022}
}
TY - JOUR T1 - Effect of Genistein on Diabetic Cardiovascular Complications AU - Na Li AU - Guomin Yang AU - Ying Pan AU - Yu Zhao Y1 - 2022/07/28 PY - 2022 N1 - https://doi.org/10.11648/j.ijde.20220703.11 DO - 10.11648/j.ijde.20220703.11 T2 - International Journal of Diabetes and Endocrinology JF - International Journal of Diabetes and Endocrinology JO - International Journal of Diabetes and Endocrinology SP - 50 EP - 53 PB - Science Publishing Group SN - 2640-1371 UR - https://doi.org/10.11648/j.ijde.20220703.11 AB - Background: Diabetes mellitus is a chronic disease caused by endocrine metabolic disorders, which has developed into a global public health problem. Currently, the number of people with diabetes has reached approximately 425 million worldwide. It is estimated that the prevalence of diabetes will increase by 48% by 2045. Genistein, a naturally occurring phytoestrogen found mainly in soybeans, is of great importance in the prevention of many diseases, including tumors and cardiovascular disease. Previous studies have shown that dietary supplementation with phytoestrogens can prevent atherosclerosis. Objective: To describe the mechanism and current status of the effect of genistein on diabetic cardiovascular complications, with the aim of improving the prognosis of patients with diabetic combined cardiovascular complications. Methods: To show the specific value of genistein in diabetic cardiovascular complications by elaborating the biochemical properties of genistein and using the interaction of genistein with vascular endothelium, platelet aggregation, lipid deposition, and inflammation as a starting point. Conclusion: The biological properties and mechanism of action of genistein can provide more references for the prevention and treatment of cardiovascular complications in clinical work. VL - 7 IS - 3 ER -
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