Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children

Maryam Mouamin; Fadl Mrabih Rabou Maoulainaine; Nabila Soraa

doi:doi:10.11648/j.ijidt.20200501.13

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Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children

Maryam Mouamin, Fadl Mrabih Rabou Maoulainaine, Nabila Soraa

Published in International Journal of Infectious Diseases and Therapy (Volume 5, Issue 1)

Received: 21 January 2020 Accepted: 11 February 2020 Published: 21 February 2020

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Abstract

The objective of this work was to evaluate the interest of RDT compared to the scores of clinical presumptions (McIsaac, PCIE, WHO) in the management of angina with SBHGA of the child while referring to the bacteriological culture. We have managed a prospective analytical study carried out over 8 months between July 2012 and February 2013 in the pediatric emergency department of the Mohammed VI UHC in Marrakech in collaboration with four pediatric practices in the liberal sector, in partnership with a Swiss medical research team from the Lausanne childhood Hospital. For each child consulting for acute angina, a clinical information sheet was completed, an RDT was carried out by the examining doctor, then a throat sample used for the classic bacteriological examination was carried out and treated by the microbiology laboratory of the Mohamed VI UHC of Marrakech. 124 children with strong suspicion of strep throat were included in the study. The average age was 6 years and 4 months with a sex ratio of 1.4 in favor of boys. The bacteriological culture demonstrated the group A hemolytic β streptococcus in=45 (36,9%). The analysis of the established clinical scores revealed the a very good sensitivity reaching 100% but with a mediocre specificity not exceeding 7,7% any score combined without notable superiority of one compared to the others. Mc Isaac's score was more positive ≥ 4 since RDT and culture were positive. The RDT showed a sensitivity of 62,2% and a specificity of 96,15% compared to the bacterial culture which is the reference examination. We retained a strong resistance to erythromycin reaching 69% associated with co-resistance to lyncomicin and spiramycinin 30% of cases. The bacterial origin to SBHG A acute angina in children from the city of Marrakech represented a third of the cases. RDT, by its sensitivity, its high specificity, its speed and its reproducibility, offers a very good means of diagnostic and therapeutic orientation and allows initiating early targeted antibiotic treatment to avoid the appearance of complications in the short, medium and long term and remedy the alarming situation of resistance to macrolides in Marrakech.

Published in	International Journal of Infectious Diseases and Therapy (Volume 5, Issue 1)
DOI	10.11648/j.ijidt.20200501.13
Page(s)	9-16
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Acute angina, Group A Beta-hemolytic Streptococcus, Clinical Scores, Rapid Diagnostic Test (RDT), Macrolide Resistance

References

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APA Style

Maryam Mouamin, Fadl Mrabih Rabou Maoulainaine, Nabila Soraa. (2020). Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children. International Journal of Infectious Diseases and Therapy, 5(1), 9-16. https://doi.org/10.11648/j.ijidt.20200501.13

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ACS Style

Maryam Mouamin; Fadl Mrabih Rabou Maoulainaine; Nabila Soraa. Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children. Int. J. Infect. Dis. Ther. 2020, 5(1), 9-16. doi: 10.11648/j.ijidt.20200501.13

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AMA Style

Maryam Mouamin, Fadl Mrabih Rabou Maoulainaine, Nabila Soraa. Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children. Int J Infect Dis Ther. 2020;5(1):9-16. doi: 10.11648/j.ijidt.20200501.13

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@article{10.11648/j.ijidt.20200501.13,
  author = {Maryam Mouamin and Fadl Mrabih Rabou Maoulainaine and Nabila Soraa},
  title = {Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {5},
  number = {1},
  pages = {9-16},
  doi = {10.11648/j.ijidt.20200501.13},
  url = {https://doi.org/10.11648/j.ijidt.20200501.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20200501.13},
  abstract = {The objective of this work was to evaluate the interest of RDT compared to the scores of clinical presumptions (McIsaac, PCIE, WHO) in the management of angina with SBHGA of the child while referring to the bacteriological culture. We have managed a prospective analytical study carried out over 8 months between July 2012 and February 2013 in the pediatric emergency department of the Mohammed VI UHC in Marrakech in collaboration with four pediatric practices in the liberal sector, in partnership with a Swiss medical research team from the Lausanne childhood Hospital. For each child consulting for acute angina, a clinical information sheet was completed, an RDT was carried out by the examining doctor, then a throat sample used for the classic bacteriological examination was carried out and treated by the microbiology laboratory of the Mohamed VI UHC of Marrakech. 124 children with strong suspicion of strep throat were included in the study. The average age was 6 years and 4 months with a sex ratio of 1.4 in favor of boys. The bacteriological culture demonstrated the group A hemolytic β streptococcus in=45 (36,9%). The analysis of the established clinical scores revealed the a very good sensitivity reaching 100% but with a mediocre specificity not exceeding 7,7% any score combined without notable superiority of one compared to the others. Mc Isaac's score was more positive ≥ 4 since RDT and culture were positive. The RDT showed a sensitivity of 62,2% and a specificity of 96,15% compared to the bacterial culture which is the reference examination. We retained a strong resistance to erythromycin reaching 69% associated with co-resistance to lyncomicin and spiramycinin 30% of cases. The bacterial origin to SBHG A acute angina in children from the city of Marrakech represented a third of the cases. RDT, by its sensitivity, its high specificity, its speed and its reproducibility, offers a very good means of diagnostic and therapeutic orientation and allows initiating early targeted antibiotic treatment to avoid the appearance of complications in the short, medium and long term and remedy the alarming situation of resistance to macrolides in Marrakech.},
 year = {2020}
}

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TY  - JOUR
T1  - Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children
AU  - Maryam Mouamin
AU  - Fadl Mrabih Rabou Maoulainaine
AU  - Nabila Soraa
Y1  - 2020/02/21
PY  - 2020
N1  - https://doi.org/10.11648/j.ijidt.20200501.13
DO  - 10.11648/j.ijidt.20200501.13
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 9
EP  - 16
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20200501.13
AB  - The objective of this work was to evaluate the interest of RDT compared to the scores of clinical presumptions (McIsaac, PCIE, WHO) in the management of angina with SBHGA of the child while referring to the bacteriological culture. We have managed a prospective analytical study carried out over 8 months between July 2012 and February 2013 in the pediatric emergency department of the Mohammed VI UHC in Marrakech in collaboration with four pediatric practices in the liberal sector, in partnership with a Swiss medical research team from the Lausanne childhood Hospital. For each child consulting for acute angina, a clinical information sheet was completed, an RDT was carried out by the examining doctor, then a throat sample used for the classic bacteriological examination was carried out and treated by the microbiology laboratory of the Mohamed VI UHC of Marrakech. 124 children with strong suspicion of strep throat were included in the study. The average age was 6 years and 4 months with a sex ratio of 1.4 in favor of boys. The bacteriological culture demonstrated the group A hemolytic β streptococcus in=45 (36,9%). The analysis of the established clinical scores revealed the a very good sensitivity reaching 100% but with a mediocre specificity not exceeding 7,7% any score combined without notable superiority of one compared to the others. Mc Isaac's score was more positive ≥ 4 since RDT and culture were positive. The RDT showed a sensitivity of 62,2% and a specificity of 96,15% compared to the bacterial culture which is the reference examination. We retained a strong resistance to erythromycin reaching 69% associated with co-resistance to lyncomicin and spiramycinin 30% of cases. The bacterial origin to SBHG A acute angina in children from the city of Marrakech represented a third of the cases. RDT, by its sensitivity, its high specificity, its speed and its reproducibility, offers a very good means of diagnostic and therapeutic orientation and allows initiating early targeted antibiotic treatment to avoid the appearance of complications in the short, medium and long term and remedy the alarming situation of resistance to macrolides in Marrakech.
VL  - 5
IS  - 1
ER  -

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Author Information

Maryam Mouamin

Microbiology Laboratory of Marrakech Mohamed VI University Hospital Center, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morocco
Fadl Mrabih Rabou Maoulainaine

Neonatology Department of Marrakech Mohamed VI University Hospital Center, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morocco
Nabila Soraa

Microbiology Laboratory of Marrakech Mohamed VI University Hospital Center, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morocco

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APA Style

Maryam Mouamin, Fadl Mrabih Rabou Maoulainaine, Nabila Soraa. (2020). Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children. International Journal of Infectious Diseases and Therapy, 5(1), 9-16. https://doi.org/10.11648/j.ijidt.20200501.13

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ACS Style

Maryam Mouamin; Fadl Mrabih Rabou Maoulainaine; Nabila Soraa. Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children. Int. J. Infect. Dis. Ther. 2020, 5(1), 9-16. doi: 10.11648/j.ijidt.20200501.13

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AMA Style

Maryam Mouamin, Fadl Mrabih Rabou Maoulainaine, Nabila Soraa. Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children. Int J Infect Dis Ther. 2020;5(1):9-16. doi: 10.11648/j.ijidt.20200501.13

Copy | Download

@article{10.11648/j.ijidt.20200501.13,
  author = {Maryam Mouamin and Fadl Mrabih Rabou Maoulainaine and Nabila Soraa},
  title = {Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {5},
  number = {1},
  pages = {9-16},
  doi = {10.11648/j.ijidt.20200501.13},
  url = {https://doi.org/10.11648/j.ijidt.20200501.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20200501.13},
  abstract = {The objective of this work was to evaluate the interest of RDT compared to the scores of clinical presumptions (McIsaac, PCIE, WHO) in the management of angina with SBHGA of the child while referring to the bacteriological culture. We have managed a prospective analytical study carried out over 8 months between July 2012 and February 2013 in the pediatric emergency department of the Mohammed VI UHC in Marrakech in collaboration with four pediatric practices in the liberal sector, in partnership with a Swiss medical research team from the Lausanne childhood Hospital. For each child consulting for acute angina, a clinical information sheet was completed, an RDT was carried out by the examining doctor, then a throat sample used for the classic bacteriological examination was carried out and treated by the microbiology laboratory of the Mohamed VI UHC of Marrakech. 124 children with strong suspicion of strep throat were included in the study. The average age was 6 years and 4 months with a sex ratio of 1.4 in favor of boys. The bacteriological culture demonstrated the group A hemolytic β streptococcus in=45 (36,9%). The analysis of the established clinical scores revealed the a very good sensitivity reaching 100% but with a mediocre specificity not exceeding 7,7% any score combined without notable superiority of one compared to the others. Mc Isaac's score was more positive ≥ 4 since RDT and culture were positive. The RDT showed a sensitivity of 62,2% and a specificity of 96,15% compared to the bacterial culture which is the reference examination. We retained a strong resistance to erythromycin reaching 69% associated with co-resistance to lyncomicin and spiramycinin 30% of cases. The bacterial origin to SBHG A acute angina in children from the city of Marrakech represented a third of the cases. RDT, by its sensitivity, its high specificity, its speed and its reproducibility, offers a very good means of diagnostic and therapeutic orientation and allows initiating early targeted antibiotic treatment to avoid the appearance of complications in the short, medium and long term and remedy the alarming situation of resistance to macrolides in Marrakech.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Interest of the Rapid Diagnostic Test in the Management of Streptotoccic Angina in Children
AU  - Maryam Mouamin
AU  - Fadl Mrabih Rabou Maoulainaine
AU  - Nabila Soraa
Y1  - 2020/02/21
PY  - 2020
N1  - https://doi.org/10.11648/j.ijidt.20200501.13
DO  - 10.11648/j.ijidt.20200501.13
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 9
EP  - 16
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20200501.13
AB  - The objective of this work was to evaluate the interest of RDT compared to the scores of clinical presumptions (McIsaac, PCIE, WHO) in the management of angina with SBHGA of the child while referring to the bacteriological culture. We have managed a prospective analytical study carried out over 8 months between July 2012 and February 2013 in the pediatric emergency department of the Mohammed VI UHC in Marrakech in collaboration with four pediatric practices in the liberal sector, in partnership with a Swiss medical research team from the Lausanne childhood Hospital. For each child consulting for acute angina, a clinical information sheet was completed, an RDT was carried out by the examining doctor, then a throat sample used for the classic bacteriological examination was carried out and treated by the microbiology laboratory of the Mohamed VI UHC of Marrakech. 124 children with strong suspicion of strep throat were included in the study. The average age was 6 years and 4 months with a sex ratio of 1.4 in favor of boys. The bacteriological culture demonstrated the group A hemolytic β streptococcus in=45 (36,9%). The analysis of the established clinical scores revealed the a very good sensitivity reaching 100% but with a mediocre specificity not exceeding 7,7% any score combined without notable superiority of one compared to the others. Mc Isaac's score was more positive ≥ 4 since RDT and culture were positive. The RDT showed a sensitivity of 62,2% and a specificity of 96,15% compared to the bacterial culture which is the reference examination. We retained a strong resistance to erythromycin reaching 69% associated with co-resistance to lyncomicin and spiramycinin 30% of cases. The bacterial origin to SBHG A acute angina in children from the city of Marrakech represented a third of the cases. RDT, by its sensitivity, its high specificity, its speed and its reproducibility, offers a very good means of diagnostic and therapeutic orientation and allows initiating early targeted antibiotic treatment to avoid the appearance of complications in the short, medium and long term and remedy the alarming situation of resistance to macrolides in Marrakech.
VL  - 5
IS  - 1
ER  -

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