Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis

Yue Wang; Kunpeng Zhang; Yali Hu; Hongmei Ma; Xiuyan Zheng; Kelu Li; Yanjuan Xie; Lijuan Pang; Lin Tao; Jianming Hu; Yan Qi; Feng Li; Wenyi Gu; Hong Zou

doi:doi:10.11648/j.jctr.20180602.11

Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis

Yue Wang, Kunpeng Zhang, Yali Hu, Hongmei Ma, Xiuyan Zheng, Kelu Li, Yanjuan Xie, Lijuan Pang, Lin Tao, Jianming Hu, Yan Qi, Feng Li, Wenyi Gu, Hong Zou

Published in Journal of Cancer Treatment and Research (Volume 6, Issue 2)

Received: 8 June 2018 Accepted: 26 June 2018 Published: 26 July 2018

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Abstract

Cervical cancer is a common gynecological malignancy that has shown a gradual increase in morbidity in recent years in China. High-risk human papillomaviruses (HR-HPVs) play a vital role in cervical cancer development and commercial vaccines are available. The overall HPV infection and geographical distribution characteristics of cervical Cancer among Chinese females have not been reported that may guide the application of the vaccines. This study systematically retrieves literature on HPV type and cervical cancer in China published from 2005 to 2017. Data are analyzed according to provinces and administrative areas for the meta-analysis. (1) SPSS17.0 software is used for the statistical data analysis. (2) χ^² inspection is also employed to analyze the infection rate of different HPV types of different cervical lesion groups in seven regions of China. Results show that China’s HR-HPV16, 58, 18, 52, 33, 31, 53, 56, 59, 51, 35, and 68 infection rates are 60.49%, 11.16%, 9.68%, 7.05%, 5.61%, 3.62%, 2.88%, 2.32%, 1.96%, 1.74%, 1.53%, and 1.52%, respectively. Differences in the HR-HPV infection rate of cervical cancer were observed among different areas, especially for HPV 31, 33, 52, and 58. The genotypes of the top five HR-HPV infection rates in cervical cancer also show differences in different regions. The results offer a basis for the prevention and treatment of cervical cancer in different parts of China. HPV type distribution in relation to cervical cancer varies among different regions and parts of China. Therefore, use of available or development of new vaccines suitable for regional types is necessary to improve the efficacy of the vaccines in preventing the primary HPV infection in different areas of China.

Published in	Journal of Cancer Treatment and Research (Volume 6, Issue 2)
DOI	10.11648/j.jctr.20180602.11
Page(s)	7-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

China, Cervical Cancer, Human Papillomavirus, Meta-analysis

References

[1]	Koh WJ, Greer BE, Abu-Rustum NR, Apte SM, Campos SM, Cho KR, et al. Cervical Cancer, Version 2. 2015. J Natl Compr Canc Netw 20152017; 13: 395-404; quiz 404-404.
[2]	de Sanjose S, Diaz M, Castellsague X, Clifford G, Bruni L, Munoz N, Bosch FX. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis 2007;7:453-9.
[3]	HPV and cervical cancer in the 2007 report. Vaccine 2007; 25 Suppl 3:C1-230.
[4]	Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N. Engl. J. Med. 2003; 348: 518-27.
[5]	Li H, Zhang J, Chen Z, Zhou B, Tan Y. Prevalence of human papillomavirus genotypes among women in Hunan province, China. Eur J Obstet Gynecol Reprod BiolEuropean journal of obstetrics, gynecology, and reproductive biology 2013; 170: 202-5.
[6]	Li J, Zhang D, Zhang Y, Wang X, Lin Y, Hu L. Prevalence and genotype distribution of human papillomavirus in women with cervical cancer or high-grade precancerous lesions in Chengdu, western China. Int J Gynaecol ObstetInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2011; 112: 131-4.
[7]	Cai HB, Ding XH, Chen CC. Prevalence of single and multiple human papillomavirus types in cervical cancer and precursor lesions in Hubei, China. OncologyOncology 2009; 76: 157-61.
[8]	Wu EQ, Yu XH, Zha X, Zhang GN, Wang JH, Fan Y, et al. Distribution of human papillomavirus genotypes in archival cervical lesions in eastern inner Mongolian autonomous region, China. Int J Gynecol CancerInternational journal of gynecological cancer: official journal of the International Gynecological Cancer Society 2009; 19: 919-23.
[9]	Hong D, Ye F, Chen H, Lu W, Cheng Q, Hu Y, Xie X. Distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in Zhejiang Province, China. Int J Gynecol CancerInternational journal of gynecological cancer: official journal of the International Gynecological Cancer Society 2008; 18: 104-9.
[10]	Zhao Y, Lin H, Shen D, Xuan Y, Lin Z. Distribution of HPV genotypes in uterine cervical lesions in Yanbian, northern China. Pathol IntPathology international 2008; 58: 643-7.
[11]	Liu XX, Fan XL, Yu YP, Ji L, Yan J, Sun AH. Human papillomavirus prevalence and type-distribution among women in Zhejiang Province, Southeast China: a cross-sectional study. BMC Infect DisBMC infectious diseases 2014; 14: 708.
[12]	Liang LY, Du H, Wang C, Zhang W, Chen Y, Qu XF, et al. [Crosssectional survey of human papilloma virus subtype distribution and cervical intraepithelial neoplasia in Shenzhen]. Beijing Da Xue Xue BaoBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2013; 45: 114-8.
[13]	Liu W, Wu EQ, Yu XH, Feng LH, Jiang CL, Zha X, Kong W. Detection of human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Changchun, China. Int J Gynaecol ObstetInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2013; 120: 124-6.
[14]	Yang L, Li N, Guo LW, Li Q, Cui H, Dai M. [Prevalence of human papilloma virus and analysis of its risk factors in Daqing city, Heilongjiang province in 2010]. Zhonghua Yu Fang Yi Xue Za Zhi 2013; 47: 118-23.
[15]	Li J, Mei J, Wang X, Hu L, Lin Y, Yang P. Human papillomavirus type-specific prevalence in women with cervical intraepithelial neoplasm in Western China. J Clin MicrobiolJournal of clinical microbiology 2012; 50: 1079-81.
[16]	Yuan X, Yang Y, Gu D, Liu H, Yang H, Wang M. Prevalence of human papillomavirus infection among women with and without normal cervical histology in Shandong Province, China. Arch Gynecol ObstetArchives of gynecology and obstetrics 2011; 283: 1385-9.
[17]	Wu D, Cai L, Huang M, Zheng Y, Yu J. Prevalence of genital human papillomavirus infection and genotypes among women from Fujian province, PR China. Eur J Obstet Gynecol Reprod BiolEuropean journal of obstetrics, gynecology, and reproductive biology 2010; 151: 86-90.
[18]	Liu X, Zhang S, Ruan Q, Ji Y, Ma L, Zhang Y. Prevalence and type distribution of human papillomavirus in women with cervical lesions in Liaoning Province, China. Int J Gynecol CancerInternational journal of gynecological cancer: official journal of the International Gynecological Cancer Society 2010; 20: 147-53.
[19]	Sun ZR, Ji YH, Zhou WQ, Zhang SL, Jiang WG, Ruan Q. Characteristics of HPV prevalence among women in Liaoning province, China. Int J Gynaecol ObstetInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2010; 109: 105-9.
[20]	Li C, Wu M, Wang J, Zhang S, Zhu L, Pan J, Zhang W. A population-based study on the risks of cervical lesion and human papillomavirus infection among women in Beijing, People's Republic of China. Cancer Epidemiol Biomarkers PrevCancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010;19:2655-64.
[21]	Zhang L, Bi Q, Deng H, Xu J, Chen J, Zhang M, Mu X. Human papillomavirus infections among women with cervical lesions and cervical cancer in Eastern China: genotype-specific prevalence and attribution. BMC Infect. Dis. 2017; 17: 107.
[22]	Wang Y, Wang S, Shen J, Peng Y, Chen L, Mai R, et al. Genotype Distribution of Human Papillomavirus among Women with Cervical Cytological Abnormalities or Invasive Squamous Cell Carcinoma in a High-Incidence Area of Esophageal Carcinoma in China. Biomed Res Int 2016; 2016: 1256384.
[23]	Li J, Wang YY, Nan X, Tian XF, Yan T, Wang P, et al. Prevalence of human papillomavirus genotypes among women with cervical lesions in the Shaanxi Province of China. Genet. Mol. Res. 2016; 15.
[24]	Xiao M, Xu Q, Li H, Gao H, Bie Y, Zhang Z. Prevalence of Human Papillomavirus Genotypes Among Women With High-Grade Cervical Lesions in Beijing, China. Medicine (Baltimore) 2016; 95: e2555.
[25]	Wang L, Wang P, Ren Y, Du J, Jiang J, Jia X, et al. Prevalence of High-Risk Human Papillomavirus (HR-HPV) Genotypes and Multiple Infections in Cervical Abnormalities from Northern Xinjiang, China. PLoS ONE 2016; 11: e0160698.
[26]	Baloch Z, Li Y, Yuan T, Feng Y, Liu Y, Tai W, et al. Epidemiologic characterization of human papillomavirus (HPV) infection in various regions of Yunnan Province of China. BMC Infect. Dis. 2016; 16: 228.
[27]	Feng YK, Peng Y, Zhu L, Niu XY. [Relationship of Human Papillomavirus Subtypes and Multiple Infection with Different Cervical Precancerous Diseases in Sichuan Province]. Sichuan Da Xue Xue Bao Yi Xue BanSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2015; 46: 422-5, 462.
[28]	Ma L, Cong X, Bian M, Shi M, Wang X, Liu J, Liu H. [High-risk HPV genotyping PCR testing as a means of cervical cancer and precancerous lesions early screening]. Zhonghua Fu Chan Ke Za ZhiZhonghua fu chan ke za zhi 2015; 50: 246-52.
[29]	Ma Q, Hou M, Yang XF. Screening of the genital human papillomavirus infection among 8581 women in the First Affiliated Hospital of Xi'an Jiaotong University. Zhongguo Yi Xue Ke Xue Yuan Xue BaoZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2014; 36: 277-82.
[30]	Ding X, Liu Z, Su J, Yan D, Sun W, Zeng Z. Human papillomavirus type-specific prevalence in women referred for colposcopic examination in Beijing. J Med VirolJournal of medical virology 2014; 86: 1937-43.
[31]	Li K, Yin R, Li Q, Wang D. Analysis of HPV distribution in patients with cervical precancerous lesions in Western China. Medicine (Baltimore) 2017;96:e7304.
[32]	Li Y, Huang K, Ji PL, Song L, Liu HT. Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China. Biomedical and environmental sciences: BES 2016; 29: 734-41.
[33]	Mai RQ, Huang B, Shen L, Zhang GH, Hong LL, Cai YM. Genotype distribution of human papillomavirus in women with abnormal cervical cytology in an esophageal carcinoma high incidence area of China. Asian Pac J Cancer PrevAsian Pacific journal of cancer prevention: APJCP 2014; 15: 4945-50.
[34]	Distribution of human papippomavirus types in cervical cancer of Xinjiang Uyghur women. Journal of International Oncology 2011; 38: 237-40.
[35]	Shui-ping H. The method of multiple comparisons of rate. Acta Academiae Medicinae Xuzhou 2002; 291-4.
[36]	JS S, L L, B H, Al E. Human papillomavirus type distributiondistributionin invasive cervical cancerand high-grade cervical lesions:ameta-analysis update. Int. J. Cancer 2007; 121: 621-32.
[37]	Clifford GM, Smith JS, Plummer M, Munoz N, Franceschi S. Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br. J. Cancer 2003; 88: 63-73.
[38]	GM C, JS S, T A, Al E. Comparison of HPV type distributionin high-grade cervical lesionsand cervical cancer:a metaanalysis. Br. J. Cancer 2003; 89: 101-5.
[39]	Chen W, Zhang X, Molijn A, Jenkins D, Shi JF, Quint W, et al. Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18. Cancer Causes Control 2009; 20: 1705-13.
[40]	Bhatla N, Lal N, Bao YP, Ng T, Qiao YL. A meta-analysis of human papillomavirus type-distribution in women from South Asia: implications for vaccination. Vaccine 2008; 26: 2811-7-.
[41]	Bao YP, Li N, Smith JS, Qiao YL. Human papillomavirus type-distribution in the cervix of Chinese women: a meta-analysis. Int J STD AIDS 2008; 19: 106-11-.
[42]	Wang L, Wu B, Li J, Chen L. Prevalence of human papillomavirus and its genotype among 1336 invasive cervical cancer patients in Hunan province, central south China. J. Med. Virol. 2015; 87: 516-21.
[43]	Jing L, Zhong X, Huang W, Liu Y, Wang M, Miao Z, et al. HPV genotypes and associated cervical cytological abnormalities in women from the Pearl River Delta region of Guangdong province, China: a cross-sectional study. BMC Infect. Dis. 2014; 14: 388.
[44]	Wu EQ, Liu B, Cui JF, Chen W, Wang JB, Lu L, et al. Prevalence of type-specific human papillomavirus and pap results in Chinese women: a multi-center, population-based cross-sectional study. Cancer Causes Control 2013; 24: 795-803.
[45]	Li J, Kang LN, Qiao YL. Review of the cervical cancer disease burden in mainland China. Asian Pac. J. Cancer Prev. 2011; 12: 1149-53.
[46]	Chan PK, Ho WC, Chan MC, Wong MC, Yeung AC, Chor JS, Hui M. Meta-analysis on prevalence and attribution of human papillomavirus types 52 and 58 in cervical neoplasia worldwide. PLoS ONE 2014;9:e107573-107573.
[47]	Zhang WJ, Li F, Wang YH, Simayi D, Saimaiti A, Zou XG, et al. The case for semi-mandatory HPV vaccination in China. Nat. Biotechnol. 2013; 31: 590-1.
[48]	US Food and Drug Administration. Gardasil 9. http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm426445.
[49]	EPF C, Machalek DA, Tabrizi SN, Danielewski JA, Fehler G, Bradshaw CS, et al. Quadrivalent vaccine-targeted human papillomavirus genotypes in heterosexual men after the Australian female human papillomavirus vaccination programme: a retrospective observational study. Lancet Infect Dis 2017; 17: 68-77.
[50]	Chow EP, Danielewski JA, Fehler G, Tabrizi SN, Law MG, Bradshaw CS, et al. Human papillomavirus in young women with Chlamydia trachomatis infection 7 years after the Australian human papillomavirus vaccination programme: a cross-sectional study. Lancet Infect Dis 2015; 15: 1314-23.
[51]	Brotherton JM, Ogilvie GS. Current status of human papillomavirus vaccination. Curr Opin Oncol 2015; 27: 399-404.

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APA Style

Yue Wang, Kunpeng Zhang, Yali Hu, Hongmei Ma, Xiuyan Zheng, et al. (2018). Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. Journal of Cancer Treatment and Research, 6(2), 7-18. https://doi.org/10.11648/j.jctr.20180602.11

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ACS Style

Yue Wang; Kunpeng Zhang; Yali Hu; Hongmei Ma; Xiuyan Zheng, et al. Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. J. Cancer Treat. Res. 2018, 6(2), 7-18. doi: 10.11648/j.jctr.20180602.11

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AMA Style

Yue Wang, Kunpeng Zhang, Yali Hu, Hongmei Ma, Xiuyan Zheng, et al. Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. J Cancer Treat Res. 2018;6(2):7-18. doi: 10.11648/j.jctr.20180602.11

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@article{10.11648/j.jctr.20180602.11,
  author = {Yue Wang and Kunpeng Zhang and Yali Hu and Hongmei Ma and Xiuyan Zheng and Kelu Li and Yanjuan Xie and Lijuan Pang and Lin Tao and Jianming Hu and Yan Qi and Feng Li and Wenyi Gu and Hong Zou},
  title = {Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis},
  journal = {Journal of Cancer Treatment and Research},
  volume = {6},
  number = {2},
  pages = {7-18},
  doi = {10.11648/j.jctr.20180602.11},
  url = {https://doi.org/10.11648/j.jctr.20180602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20180602.11},
  abstract = {Cervical cancer is a common gynecological malignancy that has shown a gradual increase in morbidity in recent years in China. High-risk human papillomaviruses (HR-HPVs) play a vital role in cervical cancer development and commercial vaccines are available. The overall HPV infection and geographical distribution characteristics of cervical Cancer among Chinese females have not been reported that may guide the application of the vaccines. This study systematically retrieves literature on HPV type and cervical cancer in China published from 2005 to 2017. Data are analyzed according to provinces and administrative areas for the meta-analysis. (1) SPSS17.0 software is used for the statistical data analysis. (2) χ² inspection is also employed to analyze the infection rate of different HPV types of different cervical lesion groups in seven regions of China. Results show that China’s HR-HPV16, 58, 18, 52, 33, 31, 53, 56, 59, 51, 35, and 68 infection rates are 60.49%, 11.16%, 9.68%, 7.05%, 5.61%, 3.62%, 2.88%, 2.32%, 1.96%, 1.74%, 1.53%, and 1.52%, respectively. Differences in the HR-HPV infection rate of cervical cancer were observed among different areas, especially for HPV 31, 33, 52, and 58. The genotypes of the top five HR-HPV infection rates in cervical cancer also show differences in different regions. The results offer a basis for the prevention and treatment of cervical cancer in different parts of China. HPV type distribution in relation to cervical cancer varies among different regions and parts of China. Therefore, use of available or development of new vaccines suitable for regional types is necessary to improve the efficacy of the vaccines in preventing the primary HPV infection in different areas of China.},
 year = {2018}
}

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TY - JOUR
T1 - Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis
AU - Yue Wang
AU - Kunpeng Zhang
AU - Yali Hu
AU - Hongmei Ma
AU - Xiuyan Zheng
AU - Kelu Li
AU - Yanjuan Xie
AU - Lijuan Pang
AU - Lin Tao
AU - Jianming Hu
AU - Yan Qi
AU - Feng Li
AU - Wenyi Gu
AU - Hong Zou
Y1 - 2018/07/26
PY - 2018
N1 - https://doi.org/10.11648/j.jctr.20180602.11
DO - 10.11648/j.jctr.20180602.11
T2 - Journal of Cancer Treatment and Research
JF - Journal of Cancer Treatment and Research
JO - Journal of Cancer Treatment and Research
SP - 7
EP - 18
PB - Science Publishing Group
SN - 2376-7790
UR - https://doi.org/10.11648/j.jctr.20180602.11
AB - Cervical cancer is a common gynecological malignancy that has shown a gradual increase in morbidity in recent years in China. High-risk human papillomaviruses (HR-HPVs) play a vital role in cervical cancer development and commercial vaccines are available. The overall HPV infection and geographical distribution characteristics of cervical Cancer among Chinese females have not been reported that may guide the application of the vaccines. This study systematically retrieves literature on HPV type and cervical cancer in China published from 2005 to 2017. Data are analyzed according to provinces and administrative areas for the meta-analysis. (1) SPSS17.0 software is used for the statistical data analysis. (2) χ² inspection is also employed to analyze the infection rate of different HPV types of different cervical lesion groups in seven regions of China. Results show that China’s HR-HPV16, 58, 18, 52, 33, 31, 53, 56, 59, 51, 35, and 68 infection rates are 60.49%, 11.16%, 9.68%, 7.05%, 5.61%, 3.62%, 2.88%, 2.32%, 1.96%, 1.74%, 1.53%, and 1.52%, respectively. Differences in the HR-HPV infection rate of cervical cancer were observed among different areas, especially for HPV 31, 33, 52, and 58. The genotypes of the top five HR-HPV infection rates in cervical cancer also show differences in different regions. The results offer a basis for the prevention and treatment of cervical cancer in different parts of China. HPV type distribution in relation to cervical cancer varies among different regions and parts of China. Therefore, use of available or development of new vaccines suitable for regional types is necessary to improve the efficacy of the vaccines in preventing the primary HPV infection in different areas of China.
VL - 6
IS - 2
ER -

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Author Information

Yue Wang

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Kunpeng Zhang

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Yali Hu

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Hongmei Ma

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Xiuyan Zheng

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Kelu Li

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Yanjuan Xie

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Lijuan Pang

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Lin Tao

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Jianming Hu

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Yan Qi

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Feng Li

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Wenyi Gu

Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, Australia
Hong Zou

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

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Yue Wang, Kunpeng Zhang, Yali Hu, Hongmei Ma, Xiuyan Zheng, et al. (2018). Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. Journal of Cancer Treatment and Research, 6(2), 7-18. https://doi.org/10.11648/j.jctr.20180602.11

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ACS Style

Yue Wang; Kunpeng Zhang; Yali Hu; Hongmei Ma; Xiuyan Zheng, et al. Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. J. Cancer Treat. Res. 2018, 6(2), 7-18. doi: 10.11648/j.jctr.20180602.11

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AMA Style

Yue Wang, Kunpeng Zhang, Yali Hu, Hongmei Ma, Xiuyan Zheng, et al. Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. J Cancer Treat Res. 2018;6(2):7-18. doi: 10.11648/j.jctr.20180602.11

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@article{10.11648/j.jctr.20180602.11,
  author = {Yue Wang and Kunpeng Zhang and Yali Hu and Hongmei Ma and Xiuyan Zheng and Kelu Li and Yanjuan Xie and Lijuan Pang and Lin Tao and Jianming Hu and Yan Qi and Feng Li and Wenyi Gu and Hong Zou},
  title = {Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis},
  journal = {Journal of Cancer Treatment and Research},
  volume = {6},
  number = {2},
  pages = {7-18},
  doi = {10.11648/j.jctr.20180602.11},
  url = {https://doi.org/10.11648/j.jctr.20180602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20180602.11},
  abstract = {Cervical cancer is a common gynecological malignancy that has shown a gradual increase in morbidity in recent years in China. High-risk human papillomaviruses (HR-HPVs) play a vital role in cervical cancer development and commercial vaccines are available. The overall HPV infection and geographical distribution characteristics of cervical Cancer among Chinese females have not been reported that may guide the application of the vaccines. This study systematically retrieves literature on HPV type and cervical cancer in China published from 2005 to 2017. Data are analyzed according to provinces and administrative areas for the meta-analysis. (1) SPSS17.0 software is used for the statistical data analysis. (2) χ² inspection is also employed to analyze the infection rate of different HPV types of different cervical lesion groups in seven regions of China. Results show that China’s HR-HPV16, 58, 18, 52, 33, 31, 53, 56, 59, 51, 35, and 68 infection rates are 60.49%, 11.16%, 9.68%, 7.05%, 5.61%, 3.62%, 2.88%, 2.32%, 1.96%, 1.74%, 1.53%, and 1.52%, respectively. Differences in the HR-HPV infection rate of cervical cancer were observed among different areas, especially for HPV 31, 33, 52, and 58. The genotypes of the top five HR-HPV infection rates in cervical cancer also show differences in different regions. The results offer a basis for the prevention and treatment of cervical cancer in different parts of China. HPV type distribution in relation to cervical cancer varies among different regions and parts of China. Therefore, use of available or development of new vaccines suitable for regional types is necessary to improve the efficacy of the vaccines in preventing the primary HPV infection in different areas of China.},
 year = {2018}
}

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