Abstract: Cholesterol is necessary for many cell functions but it can also be harmful if it is allowed to reach high blood concentrations, as the risk for premature atherosclerotic cardiovascular diseases increases. Many food supplements contain currently 10 mg of monacolin K in order to benefit of the approved claim to maintain normal blood LDL-cholesterol levels. However, the EFSA has considered that cases of adverse reactions have been reported for monacolins from red yeast rice at intake levels as low as 3 mg/day. That is the reason why the main aim of the present study was to show the effect of Policol® One new formula in patients with non-desirable lipidic profile levels. Policol® One new formula contains a wide range of plant extracts with not only a traditional use, but also a proven effect on plasma lipids. The consumption of one capsule of new Policol® One during dinner for only 4 weeks favorably affected plasma LDL-C (-39.52%) and TC (-40.52%) levels in healthy volunteers. No significant effect on TG and HDL-C was shown after 4 weeks. However, after 12 weeks TG biomarker exhibited a significant reduction (-19.91%) and HDL-C (+9.84%) also improved. No adverse effects were reported during the study. Lower lipid properties may be associated with a synergistic effect of the ingredients which allow us to formulate with a lower and safer dosage of monacolin K.Abstract: Cholesterol is necessary for many cell functions but it can also be harmful if it is allowed to reach high blood concentrations, as the risk for premature atherosclerotic cardiovascular diseases increases. Many food supplements contain currently 10 mg of monacolin K in order to benefit of the approved claim to maintain normal blood LDL-cholesterol ...Show More
Abstract: Yam (Dioscorea species) is a monocotyledonous tuber forming tropical vine which belongs to the order Liliflorae, family Dioscoreaceae, and genus Dioscorea. Conventional propagation of yam (Dioscorea spp.) is limited due to low propagation rates and highly infected by pests. However, In vitro clonal propagation is the best alternative to mass multiplication over conventional propagation. Moreover, shoot multiplication and rooting induction experiments were incubated on hormone free MS medium within 30 g/l sugar and 7 g/l agar. For shoot multiplication the initiated shoots of both landraces were cultured on MS media supplemented with 0, 1, 2, 3, 4 and 5 mg/l benzyl amino purine (BAP). For root induction, shoot lets were cultured on MS media supplemented with 0, 1, 2, 3, 4, 5 and 6 mg/l indol-3-butyric acid (IBA). Finally, for acclimatization, in vitro multiplied plantlets were transferred to greenhouse for hardening off. The results showed that the interaction effects of both landraces with BAP and IBA concentrations was significantly influenced in vitro yam shoot multiplication and rooting induction respectively. The maximum shoot number (7.23±0.21) with a maximum shoot length 7.68±0.24cm and 6.79±0.09 shoot number with 7.47±0.47 cm were obtained on MS media supplemented with 3 mg/l BAP for 11/02 and Koffea cultivars respectively. The maximum root number 10.03±0.49 and root length 10.76±0.16 cm and 10.58±0.26 root number with 10.42±0.32 cm were recorded on MS media with 3 mg/l IBA for Koffea and 11/02 cultivar respectively. In vitro raised plantlets were acclimatized and recorded 86% and 90% of survival rate in Koffea and 11/02, respectively, on soil medium with combination ratio of 2:1:1 top soil, sand soil and compost, respectively.Abstract: Yam (Dioscorea species) is a monocotyledonous tuber forming tropical vine which belongs to the order Liliflorae, family Dioscoreaceae, and genus Dioscorea. Conventional propagation of yam (Dioscorea spp.) is limited due to low propagation rates and highly infected by pests. However, In vitro clonal propagation is the best alternative to mass multip...Show More
