The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma
Tinni Trihartini Maskoen,
Budiana Rismawan,
Rangga Saputra
Issue:
Volume 8, Issue 5, September 2019
Pages:
49-53
Received:
22 July 2019
Accepted:
28 August 2019
Published:
17 September 2019
Abstract: Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.
Abstract: Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The ...
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The Analysis of Electrolyte Levels on Hypertensive Patients in Noongan Regional General Hospital, North Sulawesi, Indonesia
Diana Shintawati Purwanto,
Yanti Meilen Mewo,
Edmond Leonard Jim,
Richardo Jordan Laloan,
Joice Nancy Ansje Engka,
Billy Johnson Kepel
Issue:
Volume 8, Issue 5, September 2019
Pages:
54-60
Received:
19 September 2019
Accepted:
30 September 2019
Published:
15 October 2019
Abstract: Hypertension is one of the major risk factors of cardiovascular diseases, in addition to hypercholesterolemia and diabetes mellitus. Approximately 95% cases of hypertension in Indonesia is essential hypertension that remains unknown for the etiology and tends to be multifactorial causes. Electrolyte imbalance is thought as one of the prominent underlying mechanisms of hypertension. Electrolyte imbalance can cause serious and life-threatening cardiovascular problems. This study aimed to find out the association between electrolytes levels (serum sodium, potassium, chloride, and total calcium) and blood pressure in hypertensive patients. This was a cross-sectional study that conducted on June-August 2019 at Noongan Regional General Hospital, Minahasa Regency, North Sulawesi, Indonesia. Demographic data such as age, sex, symptoms, salt diet, and consumption of antihypertensive drugs were collected, and then physical examinations including systolic and diastolic blood pressures and body mass index (BMI) were performed. One Sample Kolmogorov-Smirnov and Spearman Rank tests were used for bivariate analysis. There is significant dirrect correlation between serum sodium levels and systolic blood pressure, and an inverse relationship with diastolic blood pressure. As for potassium, there is an inverse relationship between serum potassium levels with systolic and diastolic blood pressures, but not significant. There is a direct correlation between serum chloride levels and systolic blood pressure, and an inverse relationship with diastolic pressure, but not significant. For total calcium, there is a direct correlation between serum total calcium levels and systolic and diastolic blood pressures, but not significant. In this study, we found out only sodium has a significant correlation with blood pressure, while other electrolytes have a correlation but are not significant.
Abstract: Hypertension is one of the major risk factors of cardiovascular diseases, in addition to hypercholesterolemia and diabetes mellitus. Approximately 95% cases of hypertension in Indonesia is essential hypertension that remains unknown for the etiology and tends to be multifactorial causes. Electrolyte imbalance is thought as one of the prominent unde...
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