Science Journal of Clinical Medicine

Volume 10, Issue 2, June 2021

  • MicroRNAs as Potential Markers Involved in Erythroid Differentiation: A Systematic Literature Review

    Chunmei Guo, Xinli Li, Shuqing Liu, Mingzhong Sun

    Issue: Volume 10, Issue 2, June 2021
    Pages: 16-29
    Received: 6 April 2021
    Accepted: 19 April 2021
    Published: 23 April 2021
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    Abstract: As a family of small non-coding RNAs, microRNAs (miRNAs) negatively modulate gene expression via directly targeting mRNAs in a sequence-specific pattern. Accumulated evidences have indicated that miRNAs involved in erythroid differentiation. Some experimental systems used for study the association of miRNAs with erythroid differentiation: 1) embryo... Show More
  • Obesity as a Risk Factor Against COVID-19

    Rosa Elvira Minchala Urgilés, Anabel Estefanía Arce Prieto, Andrés Alexis Ramírez Coronel, Lilia Romero Sacoto, Fanny González León, María De Los Ángeles Estrella-González, Pedro Carlos Martínez-Suárez

    Issue: Volume 10, Issue 2, June 2021
    Pages: 30-37
    Received: 22 April 2021
    Accepted: 21 May 2021
    Published: 31 May 2021
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    Abstract: In late 2019, in Wuhan City, China, SARS-CoV2 was identified as the cause of an outbreak of acute respiratory illness called COVID-19 representing its most frequent lethal complication. Objective: To analyze, by means of a literature review, obesity as a risk factor for COVID-19. Methodology: A systematic review of the literature was carried out in... Show More
  • Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care

    Lejia Xu, Xingling Liu, Danwei Zheng, Jiawen Huang

    Issue: Volume 10, Issue 2, June 2021
    Pages: 38-41
    Received: 13 May 2021
    Accepted: 28 May 2021
    Published: 3 June 2021
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    Abstract: Background: The accuracy of test results is closely related to the clinical diagnosis and treatment, while drugs may interfere with the test results. When the abnormal value of results occured, it is important to analyze the drug-related interferential factors. Objective: To remind clinicians and pharmacists to eliminate interference factors when f... Show More
  • A Case Report: Recurrent Hyperparathyroidism After Parathyroidectomy in a Primary Hyperparathyroidism Patient with Chronic Kidney Disease

    Xia Qing Li, Kai Jun Chen, Yu Meng

    Issue: Volume 10, Issue 2, June 2021
    Pages: 42-46
    Received: 18 May 2021
    Accepted: 30 May 2021
    Published: 10 June 2021
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    Abstract: Background: Parathyroidectomy (PTX) is the definitive treatment of primary hyperparathyroidism (PHPT) for symptomatic patients. PTX for hyperparathyroidism is associated with the risk of recurrence; however, this has been mostly demonstrated in chronic kidney disease (CKD) patients with secondary hyperparathyroidism. The recurrent risk of hyperpara... Show More
  • The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury

    Yang Haoqiang, Meng Xiaoyan, Huang Xiangyang, Tan Hechang, Zhang Min, Shu Tingting

    Issue: Volume 10, Issue 2, June 2021
    Pages: 47-51
    Received: 6 May 2021
    Accepted: 24 May 2021
    Published: 25 June 2021
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    Abstract: Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional ... Show More
  • Identification of Functional Gene Modules and Biomarkers of Apatinib Against Lung Adenocarcinoma Based on Weighted Gene Co-expression Network Ansalysis (WGCNA)

    Zhang Yanli, Luo Shiqiong, Zhong Yixuan, Wu Guosong, Zhang Zhidong

    Issue: Volume 10, Issue 2, June 2021
    Pages: 52-64
    Received: 10 June 2021
    Accepted: 19 June 2021
    Published: 25 June 2021
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    Abstract: Objective: Apatinib is a drug for the treatment of gastric cancer. In recent years, studies have found that it also has good efficacy in the treatment of lung adenocarcinoma, but its mechanism of action is still not clear. Therefore, this study uses bioinformatics and Experimental verification explores the mechanism of apatinib in the treatment of ... Show More
  • The Profile of COVID-19 Exposure in Healthcare Workers in Department of Medical Rehabilitation National General Hospital Cipto Mangunkusumo

    Luh Karunia Wahyuni, Widjajalaksmi Kusumaningsih, Melinda Harini, Steven Setiono, Rizky Kusuma Wardhani, Peggy Sunarjo, Budiati Laksmitasari

    Issue: Volume 10, Issue 2, June 2021
    Pages: 65-71
    Received: 8 June 2021
    Accepted: 21 June 2021
    Published: 26 June 2021
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    Abstract: Background: Healthcare workers are a population groups at high risk of contracted by COVID-19 and some of the rehabilitation team involved in some therapeutic measures that produce the aerosol that further increase the chances of exposure to COVID-19. This study aims to assess the profile of COVID-19 exposure in healthcare worker in medical rehabil... Show More