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Analysis of Clinical and Pathological Features of a Case of Primary Carnitine Deficiency
Yanqing Kong,
Xin Wei,
Xueyu Chen
Issue:
Volume 5, Issue 1, January 2019
Pages:
1-4
Received:
24 November 2018
Accepted:
19 December 2018
Published:
21 January 2019
Abstract: In recent years, with the application of tandem mass spectrometry, an increasing number of patients with primary carnitine deficiency have been diagnosed in China. Because it is mainly concentrated in cities with good conditions, there are few reports of this disease in China. At present, the existing reports have mainly focused on screening and there are no reports addressing the degree of lesions in patients with primary carnitine deficiency. This article reports an pathological diagnosis upon autopsy of a patient with primary carnitine deficiency and describes and describes the pathological features of primary carnitine deficiency. The clinical data of the patient with primary carnitine were retrieved. A histologic analysis was performed on the liver. The autopsy pathology showed diffuse lesions in the patient's liver, interstitial pneumonia, pulmonary hemorrhage, pulmonary emphysema, and hilar lymphadenitis. The clinical response was characterized by abnormal liver function, fatty stool, abnormal renal function presenting as hematuria, and clinical manifestations such as elevated creatine kinase in the heart. Therefore, this pathological examination provides morphological diagnostic data for patients with primary carnitine deficiency and for the diagnosis of the degree of disease in these patients.
Abstract: In recent years, with the application of tandem mass spectrometry, an increasing number of patients with primary carnitine deficiency have been diagnosed in China. Because it is mainly concentrated in cities with good conditions, there are few reports of this disease in China. At present, the existing reports have mainly focused on screening and th...
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Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients
Li Meiling,
Li Long,
Meng Fuxue
Issue:
Volume 5, Issue 1, January 2019
Pages:
5-9
Received:
24 December 2018
Accepted:
22 January 2019
Published:
19 February 2019
Abstract: Objective: To detect the expression of platclet associated immunoglobulin (PAIg) on the ITP patients’ platelet surface and study the effect and correlation of blood transfusion therapy on PAIg. Methods: The 173 patients confirmed as ITP selected form the outpatients and inpatients of the Department of Hematology and Rheumatology in the Third Affiliated Hospital of Guizhou Medical University, were divided into the blood transfusion group and the non-blood transfusion group, FCM fluorescence immunolabeling was used to measure expression quantity of PAIg, the positive expression rate and fluorescence intensity of PAIgG, PAIgM and PAIgA expressed on the platelet surface of ITP patients and the control group respectively. The softwave SPSS12.0 was applied to analyze the correlation. Results: (1) PAIgG (2.96 + 8.31) %, PAIgM (2.27 + 1.78) %, PAIgA (4.48 + 3.88) % in the non-transfusion group were significantly lower than those in the transfusion group (11.44 + 20.04) %, (9.72 + 15.24) %, (10.13 + 9.53) %, P<0.001. (2) The number of platelets in the non-transfusion group was significantly negatively correlated with PAIgM, r=-0.457, P<0.05. There was no significant correlation with PAIgG and PAIgA, all P values were >0.05. Conclusion: (1) It can increase platelet antibody after blood transfusion, and patients with ITP are more likely to produce platelet antibody after blood transfusion. (2) There is a certain degree of correlation between PAIg and blood transfusion in ITP patients.
Abstract: Objective: To detect the expression of platclet associated immunoglobulin (PAIg) on the ITP patients’ platelet surface and study the effect and correlation of blood transfusion therapy on PAIg. Methods: The 173 patients confirmed as ITP selected form the outpatients and inpatients of the Department of Hematology and Rheumatology in the Third Affili...
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Progress in Research Contents and Methods of Theoretical Toxicology
Issue:
Volume 5, Issue 1, January 2019
Pages:
10-13
Received:
24 February 2019
Accepted:
2 April 2019
Published:
22 April 2019
Abstract: Toxicology is a modern science. Because of the rapid development of industry and agriculture, the amount of chemicals increases explosively. There has been more than 26,000,000 chemicals registered in the world and over 2000 new chemicals are produced every year. Therefore the traditional methods of toxicological evaluation cannot meet the requirements in the modern society, let alone the precise toxicological study for various chemicals. It is needed to make innovation in theory, so as to shorten the period, reduce the expenditure and input in the research, which may make the applications of chemicals safer. Meanwhile, as animal welfare is putting on the public agenda, less animals will be permitted to be used largely in the toxicological research. All of these promote the development of theoretical toxicology.
Abstract: Toxicology is a modern science. Because of the rapid development of industry and agriculture, the amount of chemicals increases explosively. There has been more than 26,000,000 chemicals registered in the world and over 2000 new chemicals are produced every year. Therefore the traditional methods of toxicological evaluation cannot meet the requirem...
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Implementation and Evaluation of WS531-2017 "Specification for Testing of Quality Control in Helical Tomotherapy Unit"
Cheng Xiaolong,
Liu Jiping,
Shi Jianfang
Issue:
Volume 5, Issue 1, January 2019
Pages:
14-18
Received:
17 March 2019
Accepted:
26 April 2019
Published:
15 May 2019
Abstract: Objective: To perform an annual test on the system stability of the first helical tomotherapy unit (Tomotherapy, TOMO) in Zhejiang province according to WS531-2017 "specification for testing of quality control in helical tomotherapy unit", and to further standardize the quality control operation, understand the properties of the system and ensure the accurate implementation of clinical radiotherapy. Methods: According to the requirements of WS531-2017, 8-channel measurement instrument (TomoElectrometer), ionization chamber A1SL (Standing Imaging, USA) and A17 (Standing Imaging, USA), cylindrical phantom (Cheese Phantom), equivalent rectangular solid water, two-dimensional water tank, EBT3 film, and Vidar film analyzer were used to detect 10 key indicators of TOMO. Results: The static output dose deviation was -0.6%, and the rotational output dose deviation was 1.4%. The difference between radiation quality and planned value was 0.8%. The symmetry of the horizontal dose curve of the radiation field was -1.2%; and the full width at half-maximum deviation of the longitudinal dose curve of the radiation field was 0.7mm. The horizontal offset of multi-leaf collimator was -0.6mm. The green laser offset in axial plane, sagittal plane and coronal plane were 0.08mm, 0.2mm and 0.2mm to the of virtual isocenter. The red laser light offset was -0.4mm. The movement deviation of the treatment bed was 0.3mm; and the synchronous deviation of the rotation of the treatment bed and frame was -0.6mm. Conclusion: All 10 key indicators of TOMO meet the requirement of WS531-2017. Some necessary testing items, such as MVCT image quality verification, should be added to the annual TOMO quality control in order to ensure the good stability and normal working of system.
Abstract: Objective: To perform an annual test on the system stability of the first helical tomotherapy unit (Tomotherapy, TOMO) in Zhejiang province according to WS531-2017 "specification for testing of quality control in helical tomotherapy unit", and to further standardize the quality control operation, understand the properties of the system and ensure t...
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Hemoglobin A(1c) Reporting Units and Diagnostic Cut-Offs in Relation to International Recommendations
Penttilä Ilkka,
Penttilä Karri,
Laitinen Harri,
Ranta Päivi,
Törrönen Jukka,
Rauramaa Rainer
Issue:
Volume 5, Issue 1, January 2019
Pages:
19-25
Received:
29 October 2018
Accepted:
9 January 2019
Published:
20 May 2019
Abstract: Purpose. In this account were studied the use of units and cut-off limits for hemoglobin A(1c) in worldwide clinical laboratory practice and the quality assurance ranges of hemoglobin A(1c) by calculating the target limits from the values of Labquality Ltd. and ERLGH. Methods. The use of HbA(1c) units and the diagnostic limits for diabetes were examined using e-mail and letter inquiries to 37–51 societies of laboratory medicine (mainly clinical chemistry) sent from 2009 to 2017. The parametric statistical programs of Labquality Ltd., SPSS® 13.0, and MS Excel 2013 (Microsoft® Co., Cambridge, MA, USA) were used. Results. The mean values of the Finnish quality control organization Labquality Ltd. and the corresponding values from the HbA(1c) queries as to the percentage and mmol/mol SI units (IFCC) were used. The IFCC system for hemoglobin A(1c) is slowly but constantly gaining acceptance in Europe, but remains quite rare outside Europe where the percentage results were correspondingly lower. The mean round values of Labquality Ltd. and the corresponding mean values of the European Reference Laboratory for Glycohemoglobin (ERLGH) showed equal ranges for calculation of the target values with ± 6% intervals for the percentage results and ± 8% intervals for the mmol/mol results. Conclusions. To avoid confusion, the overall use of mmol/mol as a single unit for HbA(1c) may be the best option when the IFCC system has been accepted worldwide. The target values can be calculated equally well from the mean values of Labquality Ltd. and the ERLGH values in terms of both per percentage and mmol/mol units.
Abstract: Purpose. In this account were studied the use of units and cut-off limits for hemoglobin A(1c) in worldwide clinical laboratory practice and the quality assurance ranges of hemoglobin A(1c) by calculating the target limits from the values of Labquality Ltd. and ERLGH. Methods. The use of HbA(1c) units and the diagnostic limits for diabetes were exa...
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